Lilrb4b MGI Mouse Gene Detail - MGI:102702 - leukocyte immunoglobulin-like receptor, subfamily B, member 4B

Lilrb4b Gene Detail

Symbol

Lilrb4b
Name

leukocyte immunoglobulin-like receptor, subfamily B, member 4B
Synonyms

gp49, Gp49a, Lilr4b

Feature Type

protein coding gene
IDs

MGI:102702
NCBI Gene: 14727
Alliance

gene page
Transcription Start Sites

27 TSS

Sequence Map

Chr10:51356757-51362417 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 25.50 cM
Mapping Data

1 experiment

SNPs within 2kb

139 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102702	protein coding gene	Chr10:51356728-51362799 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

LILRB4, leukocyte immunoglobulin like receptor B4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LILRB4, leukocyte immunoglobulin like receptor B4
Synonyms

B4, CD85K, ILT3, ILT-3, LIR5, LIR-5
Links

HGNC:6608

NCBI Gene ID: 11006

neXtProt AC: NX_Q8NHJ6

UniProt: Q8NHJ6
Chr Location

19q13.42; chr19:54643889-54670359 (+) GRCh38

MGI Vertebrate Homology

Lilrb4b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LILRB4
Gene Tree

Lilrb4b

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Genomic Mutations

2 involving Lilrb4b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

42
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

8
UniProt

4
CCDS

CCDS23831.1, CCDS88004.1

Ensembl

ENSMUSG00000112023 (Evidence)
NCBI Gene

14727

			Length	Strain/Species	Flank
genomic	14727	NCBI Gene Model \| MGI Sequence Detail	5661	C57BL/6J	± kb
transcript	NM_001291892	RefSeq \| MGI Sequence Detail	1430	C57BL/6
polypeptide	Q61450	UniProt \| EBI \| MGI Sequence Detail	303	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008377 leukocyte immunoglobulin-like receptor subfamily B member 4B

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

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All nucleic 26

Genomic 2

cDNA 24

Microarray probesets 2

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MGD-MRK-19606

Summaries

All 36

Gene Ontology 5

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

TSS for Lilrb4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93233	Chr10:51356909-51356930 (+)	163 bp
Tssr93234	Chr10:51356935-51356946 (+)	184 bp
Tssr93235	Chr10:51357228-51357240 (+)	477 bp
Tssr93236	Chr10:51357714-51357752 (+)	976 bp
Tssr93237	Chr10:51357753-51357770 (+)	1,005 bp
Tssr93238	Chr10:51357777-51357787 (+)	1,025 bp
Tssr93239	Chr10:51357802-51357816 (+)	1,052 bp
Tssr93240	Chr10:51357819-51357838 (+)	1,072 bp
Tssr93241	Chr10:51357841-51357848 (+)	1,088 bp
Tssr93242	Chr10:51357881-51357894 (+)	1,131 bp
Tssr93243	Chr10:51358674-51358709 (+)	1,935 bp
Tssr93244	Chr10:51358940-51358980 (+)	2,203 bp
Tssr93245	Chr10:51359463-51359516 (+)	2,733 bp
Tssr93246	Chr10:51359679-51359701 (+)	2,933 bp
Tssr93247	Chr10:51359725-51359744 (+)	2,978 bp
Tssr93248	Chr10:51359773-51359785 (+)	3,022 bp
Tssr93249	Chr10:51359918-51359951 (+)	3,178 bp
Tssr93250	Chr10:51360405-51360412 (+)	3,652 bp
Tssr93251	Chr10:51360444-51360473 (+)	3,702 bp
Tssr93252	Chr10:51360547-51360568 (+)	3,801 bp
Tssr93253	Chr10:51360742-51360764 (+)	3,996 bp
Tssr93254	Chr10:51360869-51360897 (+)	4,126 bp
Tssr93255	Chr10:51361096-51361115 (+)	4,349 bp
Tssr93256	Chr10:51361208-51361218 (+)	4,456 bp
Tssr93257	Chr10:51361571-51361603 (+)	4,830 bp
Tssr93258	Chr10:51361806-51361843 (+)	5,068 bp
Tssr93259	Chr10:51361848-51361858 (+)	5,096 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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