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Lilrb4a
Gene Detail
Symbol

Name
ID
Lilrb4a
leukocyte immunoglobulin-like receptor, subfamily B, member 4A
MGI:102701
Synonyms
CD85K, Gp49b, HM18, ILT3, Lilrb4
Feature Type
protein coding gene
Genetic Map
Chromosome 10
25.50 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr10:51480640-51496613 bp, + strand
From VEGA annotation of GRCm38

  15974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86756  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: LILRB4
Gene Tree: Lilrb4a

Human
homologs
LILRB4, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11006
neXtProt AC: NX_Q8NHJ6

Human Synonyms: CD85K, ILT3, ILT-3, LIR5, LIR-5

Human Chr (Location): 19q13.4; chr19:54643835-54670359 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit increased sensitivity to IgE-dependent passive cutaneous anaphylaxis and a reduced threshold for antigen challenge in active cutaneous anaphylaxis.
 
Interactions
Lilrb4a interacts with 122 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process adaptive immune response, immune system process
Component extracellular exosome, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (19)    Tissues (19)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(4) cDNA(32)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016501 (Evidence)
Ensembl Gene Model ENSMUSG00000062593 (Evidence)
Entrez Gene 14728 (Evidence)
UniGene 34408
Consensus CDS Project CCDS23832.1
International Mouse Phenotyping Consortium Status Lilrb4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016501 VEGA Gene Model | MGI Sequence Detail 15974 C57BL/6J ±  kb
transcript OTTMUST00000039857 VEGA | MGI Sequence Detail 1441 Not Applicable 
polypeptide OTTMUSP00000017778 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(7) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(306 from dbSNP Build 137)    SNPs within 2kb including multiple locations(344)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000009811 leukocyte immunoglobulin-like receptor subfamily B member 4
References
(Earliest) J:17206 Castells MC, et al., Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J Biol Chem. 1994 Mar 18;269(11):8393-401
(Latest) J:197195 Fanning LB, et al., Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation. PLoS One. 2013;8(2):e57007
All references(44)
Other
accession IDs
MGD-MRK-19605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory