About   Help   FAQ
Lilrb4
Gene Detail
 Symbol
Name
ID
Lilrb4
leukocyte immunoglobulin-like receptor, subfamily B, member 4
MGI:102701
Synonyms CD85K, Gp49b, HM18, ILT3
Feature Type protein coding gene
Genetic Map
Chromosome 10
25.50 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr10:51480640-51496613 bp, + strand
From VEGA annotation of GRCm38

  15974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86756  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Lilrb4

Human
homologs
Human Homolog LILRB4, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
NCBI Gene ID 11006
neXtProt AC  NX_Q8NHJ6
Human Synonyms  CD85K, ILT3, ILT-3, LIR5, LIR-5
Human Chr (Location)  19q13.4; chr19:54662819-54670359 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit increased sensitivity to IgE-dependent passive cutaneous anaphylaxis and a reduced threshold for antigen challenge in active cutaneous anaphylaxis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process immune system process
Component extracellular vesicular exosome, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (19)    Tissues (19)    Images (2)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 19
cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) Genomic(4) cDNA(32)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016501 (Evidence)
Ensembl Gene ModelENSMUSG00000062593 (Evidence)
Entrez Gene14728 (Evidence)
UniGene34408
Consensus CDS ProjectCCDS23832.1
International Mouse Knockout Project StatusLilrb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016501 VEGA Gene Model | MGI Sequence Detail 15974 C57BL/6J ±  kb
transcript OTTMUST00000039857 VEGA | MGI Sequence Detail 1441 Not Applicable 
polypeptide OTTMUSP00000017778 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(306 from dbSNP Build 137)    SNPs within 2kb including multiple locations(344)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000009811 leukocyte immunoglobulin-like receptor subfamily B member 4
References (Earliest) J:17206 Castells MC, et al., Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J Biol Chem. 1994 Mar 18;269(11):8393-401
(Latest) J:197195 Fanning LB, et al., Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation. PLoS One. 2013;8(2):e57007
All references(45)
Other
accession IDs
MGD-MRK-19605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory