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Lilrb4a Gene Detail
Summary
  • Symbol
    Lilrb4a
  • Name
    leukocyte immunoglobulin-like receptor, subfamily B, member 4A
  • Synonyms
    CD85K, Gp49b, HM18, ILT3, Lilrb4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102701
    NCBI Gene: 14728
  • Gene Overview
    MyGene.info: LILRB4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:51490956-51496611 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5656 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 25.50 cM, cytoband B4
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LILRB4, leukocyte immunoglobulin like receptor B4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    LILRB4, leukocyte immunoglobulin like receptor B4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD85K, ILT3, ILT-3, LIR5, LIR-5
  • Links
    NCBI Gene ID: 11006
    neXtProt AC: NX_Q8NHJ6
    UniProt: Q8NHJ6

  • Chr Location
    19q13.42; chr19:54662524-54670359 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit increased sensitivity to IgE-dependent passive cutaneous anaphylaxis and a reduced threshold for antigen challenge in active cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000112148 Ensembl Gene Model | MGI Sequence Detail 5656 C57BL/6J ±  kb
transcript ENSMUST00000078778 Ensembl | MGI Sequence Detail 1381 Not Applicable  
polypeptide ENSMUSP00000077833 Ensembl | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    139 from dbSNP Build 142
  • RFLP
Molecular
Reagents
less
  • All nucleic 36
    Genomic 4
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19605
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Phenotypes 19
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:197195 Fanning LB, et al., Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation. PLoS One. 2013;8(2):e57007

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/03/2018
MGI 6.11
The Jackson Laboratory