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Lilrb4a Gene Detail
Summary
  • Symbol
    Lilrb4a
  • Name
    leukocyte immunoglobulin-like receptor, subfamily B, member 4A
  • Synonyms
    CD85K, Gp49b, HM18, ILT3, Lilrb4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102701
    NCBI Gene: 14728
  • Gene Overview
    MyGene.info: LILRB4
Location & Maps
more
  • Sequence Map
    Chr10:51480640-51496613 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15974 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 25.50 cM, cytoband B4
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LILRB4, leukocyte immunoglobulin like receptor B4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    LILRB4, leukocyte immunoglobulin like receptor B4
    Orthology source: HomoloGene
  • Synonyms
    CD85K, ILT3, ILT-3, LIR5, LIR-5
  • Links
    NCBI Gene ID: 11006
    neXtProt AC: NX_Q8NHJ6

  • Chr Location
    19q13.4; chr19:54643835-54670359 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Lilrb4a
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit increased sensitivity to IgE-dependent passive cutaneous anaphylaxis and a reduced threshold for antigen challenge in active cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016501 VEGA Gene Model | MGI Sequence Detail 15974 C57BL/6J ±  kb
transcript OTTMUST00000039857 VEGA | MGI Sequence Detail 1441 Not Applicable  
polypeptide OTTMUSP00000017778 VEGA | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    287 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 36
    Genomic 4
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19605
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 19
  • Earliest
    J:17206 Castells MC, et al., Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J Biol Chem. 1994 Mar 18;269(11):8393-401
  • Latest
    J:197195 Fanning LB, et al., Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation. PLoS One. 2013;8(2):e57007

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory