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Ptprf
Gene Detail
Symbol

Name
ID
Ptprf
protein tyrosine phosphatase, receptor type, F
MGI:102695
Synonyms
LAR, RPTP-LAR
Feature Type
protein coding gene
Genetic Map
Chromosome 4
54.47 cM, cytoband C6-D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:118208213-118291405 bp, - strand
From VEGA annotation of GRCm38

  83193 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PTPRF
Protein SuperFamily: leukocyte antigen-related receptor-type tyrosine-protein phosphatase
Gene Tree: Ptprf

Human
homologs
PTPRF, protein tyrosine phosphatase, receptor type, F
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5792
neXtProt AC: NX_P10586

Human Synonyms: BNAH2, LAR

Human Chr (Location): 1p34; chr1:43522238-43623672 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTPRF

Mutations,
alleles, and
phenotypes
All mutations/alleles(136) : Gene trapped(132) Targeted(4)
Genomic Mutations involving Ptprf (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null females have premature involution of the mammary glands leading to an inability to feed pups. Other characteristics of null mice include defective nerve regeneration and hyperactivity.
 
Interactions
Ptprf interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cell adhesion, cell migration, ...
Component endosome, excitatory synapse, ...
Function chondroitin sulfate proteoglycan binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (3)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(22)
Other mouse links: GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PTPRF ; Xenbase ptprf ; ZFIN ptprfa, ptprfb    NEW 
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(22) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000008720 (Evidence)
Ensembl Gene Model ENSMUSG00000033295 (Evidence)
Entrez Gene 19268 (Evidence)
DFCI TC1616735, TC1574368, TC1702356, TC1678201
DoTS DT.103577919, DT.101738918, DT.494639, DT.97364145
NIA Mouse Gene Index U025443
EC 3.1.3.48
PDB 3PXH
Consensus CDS Project CCDS18546.1
International Mouse Phenotyping Consortium Status Ptprf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008720 VEGA Gene Model | MGI Sequence Detail 83193 C57BL/6J ±  kb
transcript OTTMUST00000019809 VEGA | MGI Sequence Detail 7656 Not Applicable 
polypeptide OTTMUSP00000009082 VEGA | MGI Sequence Detail 1898 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(26) UniProt(8)
Polymorphisms
SNPs within 2kb(507 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013469 receptor-type tyrosine-protein phosphatase F
References
(Earliest) J:14647 Streuli M, et al., A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen. J Exp Med. 1988 Nov 1;168(5):1523-30
(Latest) J:218452 Xu B, et al., Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury. Neurobiol Dis. 2015 Jan;73:36-48
All references(66)
Other
accession IDs
MGD-MRK-19599, MGI:2140169

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory