Ptprf
Gene Detail

Symbol Name ID

Ptprf protein tyrosine phosphatase, receptor type, F MGI:102695

Synonyms

LAR, RPTP-LAR

Feature Type

protein coding gene

Genetic Map

Chromosome 4

54.47 cM, cytoband C6-D1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:118208213-118291405 bp, - strand From VEGA annotation of GRCm38   83193 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: leukocyte antigen-related receptor-type tyrosine-protein phosphatase
Gene Tree: Ptprf

Human homologs

Human Homolog		PTPRF, protein tyrosine phosphatase, receptor type, F
NCBI Gene ID		5792
neXtProt AC		NX_P10586
Human Synonyms		LAR
Human Chr (Location)		1p34; chr1:43996547-44089343 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(135) : Targeted(3) Gene trapped(132)
 

Homozygous null females have premature involution of the mammary glands leading to an inability to feed pups. Other characteristics of null mice include defective nerve regeneration and hyperactivity.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	cell adhesion, dephosphorylation, ...
Component	endosome, excitatory synapse, ...
Function	heparin binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 21, 28

Assay Type	Results
RT-PCR	3

cDNA source data(22)
External Resources: GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(2) cDNA(22) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000008720 (Evidence)
Ensembl Gene Model	ENSMUSG00000033295 (Evidence)
Entrez Gene	19268 (Evidence)
DFCI	TC1574368, TC1616735, TC1678201, TC1702356
DoTS	DT.101738918, DT.103577919, DT.494639, DT.97364145
NIA Mouse Gene Index	U025443
EC	3.1.3.48
PDB	3PXH
Consensus CDS Project	CCDS18546.1
International Mouse Knockout Project Status	Ptprf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008720	VEGA Gene Model | MGI Sequence Detail	83193	C57BL/6J
transcript	OTTMUST00000019809	VEGA | MGI Sequence Detail	7656	Not Applicable
polypeptide	OTTMUSP00000009082	VEGA | MGI Sequence Detail	1898	Not Applicable

All sequences(67) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(445 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013469	receptor-type tyrosine-protein phosphatase F

References

(Earliest) J:14647 Streuli M, et al., A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen. J Exp Med. 1988 Nov 1;168(5):1523-30
(Latest) J:177108 Fisher D, et al., Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors. J Neurosci. 2011 Oct 5;31(40):14051-14066
All references(64)

Other accession IDs

MGD-MRK-19599, MGI:2140169