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Ptprm Gene Detail
Summary
  • Symbol
    Ptprm
  • Name
    protein tyrosine phosphatase, receptor type, M
  • Synonyms
    RPTPmu
  • Feature Type
    protein coding gene
  • IDs
    MGI:102694
    NCBI Gene: 19274
  • Gene Overview
    MyGene.info: PTPRM
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66666947-67354457 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 37.88 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4620 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102694
protein coding gene Chr17:66666848-67354459 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023990
protein coding gene Chr17:68902099-69627124 (-)
A/J MGP_AJ_G0023948
protein coding gene Chr17:66806598-67515706 (-)
AKR/J MGP_AKRJ_G0023917
protein coding gene Chr17:67753475-68460915 (-)
BALB/cJ MGP_BALBcJ_G0023949
protein coding gene Chr17:66760424-67460289 (-)
C3H/HeJ MGP_C3HHeJ_G0023713
protein coding gene Chr17:68637248-69353276 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024395
protein coding gene Chr17:71515033-72235486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021841
protein coding gene Chr17:62791050-63473151 (-)
CAST/EiJ MGP_CASTEiJ_G0023195
protein coding gene Chr17:68978590-69729677 (-)
CBA/J MGP_CBAJ_G0023689
protein coding gene Chr17:74344861-75124259 (-)
DBA/2J MGP_DBA2J_G0023817
protein coding gene Chr17:65538263-66233355 (-)
FVB/NJ MGP_FVBNJ_G0023783
protein coding gene Chr17:65034213-65725154 (-)
LP/J MGP_LPJ_G0023899
protein coding gene Chr17:69604093-70335363 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023811
protein coding gene Chr17:74414707-75160685 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024439
protein coding gene Chr17:68184817-68906566 (-)
PWK/PhJ MGP_PWKPhJ_G0022941
protein coding gene Chr17:64813088-65549124 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022752
protein coding gene Chr17:64887046-65634626 (-)
WSB/EiJ MGP_WSBEiJ_G0023261
protein coding gene Chr17:68939895-69656474 (-)



Homology
more
  • Human Ortholog
    PTPRM, protein tyrosine phosphatase, receptor type M
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PTPRM, protein tyrosine phosphatase, receptor type M
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hR-PTPu, PTPRL1, RPTPM, R-PTP-MU, RPTPU
  • Links
    NCBI Gene ID: 5797
    neXtProt AC: NX_P28827
    UniProt: P28827

  • Chr Location
    18p11.23; chr18:7567316-8406861 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired flow-induced dilation in mesenteric resistance arteries.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033278 Ensembl Gene Model | MGI Sequence Detail 687511 C57BL/6J ±  kb
transcript ENSMUST00000037974 Ensembl | MGI Sequence Detail 5186 Not Applicable  
polypeptide ENSMUSP00000045603 Ensembl | MGI Sequence Detail 1486 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 57
    cDNA 52
    Primer pair 1
    Other 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19598
References
more
  • Summaries
    All 43
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:14621 Gebbink MF, et al., Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. FEBS Lett. 1991 Sep 23;290(1-2):123-30
  • Latest
    J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory