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Srm Gene Detail
Summary
  • Symbol
    Srm
  • Name
    spermidine synthase
  • Synonyms
    SpdST, SpdSy
  • Feature Type
    protein coding gene
  • IDs
    MGI:102690
    NCBI Gene: 20810
Location & Maps
more
  • Sequence Map
    Chr4:148591503-148594993 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3491 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.76 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SRM, spermidine synthase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SRM, spermidine synthase
    Orthology source: HomoloGene
  • Synonyms
    PAPT, SPDSY, SPS1, SRML1
  • Links
    NCBI Gene ID: 6723
    neXtProt AC: NX_P19623

  • Chr Location
    1p36-p22; chr1:11054592-11060034 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    7
  • Gene trapped
    5
  • Targeted
    2
  • Genomic Mutations
    1 involving Srm
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010928 VEGA Gene Model | MGI Sequence Detail 3491 C57BL/6J ±  kb
transcript OTTMUST00000025629 VEGA | MGI Sequence Detail 1338 Not Applicable  
polypeptide OTTMUSP00000011743 VEGA | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015621 spermidine synthase
  • EC
  • InterPro Domains
    IPR030374 Polyamine biosynthesis domain
    IPR030373 Polyamine biosynthesis domain, conserved site
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    IPR030668 Spermidine/spermine synthase, eukaryotes
    IPR001045 Spermidine/spermine synthases
Molecular
Reagents
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  • All nucleic 123
    cDNA 122
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-19593, MGI:2140122
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:36968 Kauppinen L, et al., Transgenic mice over-expressing the human spermidine synthase gene. Biochem J. 1993 Jul 15;293(Pt 2):513-6
  • Latest
    J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory