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H2afx
Gene Detail
Symbol

Name
ID
H2afx
H2A histone family, member X
MGI:102688
Synonyms
gammaH2ax, H2ax, H2A.X, Hist5-2ax
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:44334694-44336077 bp, + strand
From VEGA annotation of GRCm38

  1384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134201  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: histone H2A
Gene Tree: H2afx

Human
homologs
Human Homolog H2AFX, H2A histone family, member X
NCBI Gene ID 3014
neXtProt AC  NX_P16104
Human Synonyms  H2AX, H2A/X, H2A.X
Human Chr (Location)  11q23.3; chr11:119093874-119095467 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Homozygous null mice are smaller and display increased susceptibility to ionizing radiation, male infertility, T and B cell abnormalities, and increased genomic instability.
 
Interactions
H2afx interacts with 79 markers (Mir22, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component chromatin, chromosome, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (95 records)
Data Summary: Results (60)    Tissues (30)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 25
RNA in situ 34
Western blot 1
cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) Genomic(3) cDNA(92)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000042356 (Evidence)
Ensembl Gene ModelENSMUSG00000049932 (Evidence)
Entrez Gene15270 (Evidence)
UniGene245931
DFCITC1575099
DoTSDT.101180324, DT.55282168
NIA Mouse Gene IndexU010382
Consensus CDS ProjectCCDS23105.1
International Mouse Knockout Project StatusH2afx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042356 VEGA Gene Model | MGI Sequence Detail 1384 C57BL/6J ±  kb
transcript OTTMUST00000111622 VEGA | MGI Sequence Detail 1384 Not Applicable 
polypeptide OTTMUSP00000062531 VEGA | MGI Sequence Detail 143 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007125 Histone core
InterPro IPR009072 Histone-fold
InterPro IPR002119 Histone H2A
Protein Ontology PR:000008418 histone H2A.x
References
(Earliest) J:11221 Nagata T, et al., Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene. Nucleic Acids Res. 1991 May 11;19(9):2441-7
(Latest) J:211663 Fukuda T, et al., STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis. EMBO J. 2014 Jun 2;33(11):1243-55
All references(204)
Other
accession IDs
MGD-MRK-19571, MGD-MRK-19591, MGI:2143303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory