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Bcl2a1a Gene Detail
Summary
  • Symbol
    Bcl2a1a
  • Name
    B cell leukemia/lymphoma 2 related protein A1a
  • Synonyms
    A1, Bcl2a1, Bfl-1, Hbpa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102687
    NCBI Gene: 12044
  • Gene Overview
    MyGene.info: BCL2A1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:88956900-88962419 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5520 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 47.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACC1, ACC-1, ACC2, ACC-2, BCL2L5, BFL1, GRS, HBPA1
  • Links
    NCBI Gene ID: 597
    neXtProt AC: NX_Q16548
    UniProt: Q16548

  • Chr Location
    15q25.1; chr15:79960890-79971301 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants show enhanced spontaneous apoptosis of neutrophils, while both heterozygous and homozygous null mutants lack LPS-induced neutrophil apoptosis inhibition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000045614 VEGA Gene Model | MGI Sequence Detail 5520 C57BL/6J ±  kb
    transcript OTTMUST00000121120 VEGA | MGI Sequence Detail 819 Not Applicable  
    polypeptide OTTMUSP00000066851 VEGA | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      9 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 3
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-18735, MGD-MRK-19590, MGI:2143372
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:22455 Lin EY, et al., Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol. 1993 Aug 15;151(4):1979-88
    • Latest
      J:260482 Tuzlak S, et al., The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection. Cell Death Differ. 2017 Mar;24(3):523-533

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory