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Bcl2a1a Gene Detail
Summary
  • Symbol
    Bcl2a1a
  • Name
    B cell leukemia/lymphoma 2 related protein A1a
  • Synonyms
    A1, Bcl2a1, Bfl-1, Hbpa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102687
    NCBI Gene: 12044
  • Gene Overview
    MyGene.info: BCL2A1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:88956920-88962416 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 47.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    8
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102687
protein coding gene Chr9:88956900-88962419 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0035025
protein coding gene Chr9:88558210-88570133 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0034795
protein coding gene Chr9:89238975-89239970 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0034926
protein coding gene Chr9:86020950-86032261 (-)
FVB/NJ MGP_FVBNJ_G0034870
protein coding gene Chr9:85079882-85084915 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0034913
protein coding gene Chr9:97456356-97472991 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0033816
protein coding gene Chr9:86706654-86719974 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0034230
protein coding gene Chr9:89143992-89149671 (+)



Homology
more
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACC1, ACC-1, ACC2, ACC-2, BCL2L5, BFL1, GRS, HBPA1
  • Links
    NCBI Gene ID: 597
    neXtProt AC: NX_Q16548
    UniProt: Q16548

  • Chr Location
    15q25.1; chr15:79960890-79971301 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants show enhanced spontaneous apoptosis of neutrophils, while both heterozygous and homozygous null mutants lack LPS-induced neutrophil apoptosis inhibition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12044 NCBI Gene Model | MGI Sequence Detail 5497 C57BL/6J ±  kb
    transcript NM_009742 RefSeq | MGI Sequence Detail 796 C57BL/6  
    polypeptide Q07440 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 3
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-18735, MGD-MRK-19590, MGI:2143372
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 6
    • Earliest
      J:22455 Lin EY, et al., Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol. 1993 Aug 15;151(4):1979-88
    • Latest
      J:260482 Tuzlak S, et al., The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection. Cell Death Differ. 2017 Mar;24(3):523-533

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory