Grb7 MGI Mouse Gene Detail - MGI:102683 - growth factor receptor bound protein 7

Symbol

Grb7
Name

growth factor receptor bound protein 7

Feature Type

protein coding gene
IDs

MGI:102683
NCBI Gene: 14786
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:98337660-98346199 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.75 cM
Mapping Data

3 experiments

SNPs within 2kb

15 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102683	protein coding gene	Chr11:98337220-98346199 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019061	protein coding gene	Chr11:100995036-101005693 (+)
A/J	MGP_AJ_G0019029	protein coding gene	Chr11:96793206-96801955 (+)
AKR/J	MGP_AKRJ_G0018999	protein coding gene	Chr11:99792599-99802352 (+)
BALB/cJ	MGP_BALBcJ_G0019002	protein coding gene	Chr11:97286529-97295506 (+)
C3H/HeJ	MGP_C3HHeJ_G0018816	protein coding gene	Chr11:99925553-99935220 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019455	protein coding gene	Chr11:104080592-104089985 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017086	protein coding gene	Chr11:94231690-94240670 (+)
CAST/EiJ	MGP_CASTEiJ_G0018370	protein coding gene	Chr11:100805337-100822917 (+)
CBA/J	MGP_CBAJ_G0018787	protein coding gene	Chr11:108392950-108409292 (+)
DBA/2J	MGP_DBA2J_G0018895	protein coding gene	Chr11:96335617-96344438 (+)
FVB/NJ	MGP_FVBNJ_G0018884	protein coding gene	Chr11:95844761-95853635 (+)
LP/J	MGP_LPJ_G0018965	protein coding gene	Chr11:101468944-101479809 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018911	protein coding gene	Chr11:108182168-108191139 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019495	protein coding gene	Chr11:100122838-100133138 (+)
PWK/PhJ	MGP_PWKPhJ_G0018142	protein coding gene	Chr11:97343644-97352645 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017932	protein coding gene	Chr11:99825061-99834016 (+)
WSB/EiJ	MGP_WSBEiJ_G0018420	protein coding gene	Chr11:100037788-100046774 (+)

Human Ortholog

GRB7, growth factor receptor bound protein 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRB7, growth factor receptor bound protein 7
Links

HGNC:4567

NCBI Gene ID: 2886

neXtProt AC: NX_Q14451

UniProt: Q14451
Chr Location

17q12; chr17:39737927-39747291 (+) GRCh38

MGI Vertebrate Homology

Grb7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRB7
Gene Tree

Grb7

Diseases

1 with human GRB7 associations

				Human Disease	Mouse Models
				esophagus adenocarcinoma IDs esophagus adenocarcinoma DOID:4914 MESH:C562730 NCI:C4025 UMLS_CUI:C0279628

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

7
Targeted

7
Genomic Mutations

1 involving Grb7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and survive to adulthood with no overt abnormalities. However, litters born to knockout females fail to thrive to weaning age.

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All GO Annotations

26
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

972
Tissues

60
cDNA Data

113
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grb7

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All Sequences

50
RefSeq

6
UniProt

3
CCDS

CCDS25351.1

Ensembl

ENSMUSG00000019312 (Evidence)
NCBI Gene

14786

			Length	Strain/Species	Flank
genomic	14786	NCBI Gene Model \| MGI Sequence Detail	8540	C57BL/6J	± kb
transcript	NM_010346	RefSeq \| MGI Sequence Detail	2413	ZRU/MplStud
polypeptide	Q03160	UniProt \| EBI \| MGI Sequence Detail	535	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008225 growth factor receptor-bound protein 7

(term hierarchy)
InterPro Domains

IPR039665 APBB1IP, PH domain

IPR015042 BPS (Between PH and SH2) domain

IPR039664 GRB/APBB1IP

IPR046986 Growth factor receptor-bound protein 7, RA domain

IPR035032 Growth factor receptor-bound protein 7, SH2 domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR000159 Ras-associating domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 116

cDNA 113

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-19586

Summaries

All 52

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 17
Earliest

J:39581 Margolis B, et al., High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8894-8
Latest

J:344139 Lofgren KA, et al., Grb7 knockout mice develop normally but litters born to knockout females fail to thrive. Dev Dyn. 2023 Dec 23;

TSS for Grb7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104740	Chr11:98337652-98337695 (+)	14 bp
Tssr104741	Chr11:98337839-98337888 (+)	204 bp
Tssr104742	Chr11:98337890-98337908 (+)	239 bp
Tssr104743	Chr11:98337914-98337926 (+)	260 bp
Tssr104744	Chr11:98337943-98337952 (+)	288 bp
Tssr104745	Chr11:98342659-98342665 (+)	5,002 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23