Homozygous mutant mice die neonatally exhibiting hydroencephaly. Neural progenitor cell physiology is abnormal, resulting in a loss of cell polarity and the development of neuroepithelial rosette-like structures throughout the brain.
|InterPro||IPR000664||Lethal(2) giant larvae protein|
|InterPro||IPR013577||Lethal giant larvae homologue 2|
|InterPro||IPR013905||Lethal giant larvae (Lgl)-like, C-terminal|
|InterPro||IPR019775||WD40 repeat, conserved site|
|InterPro||IPR015943||WD40/YVTN repeat-like-containing domain|
|Protein Ontology||PR:000009847||lethal(2) giant larvae protein homolog 1|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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