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Llgl1
Gene Detail
Symbol

Name
ID
Llgl1
lethal giant larvae homolog 1 (Drosophila)
MGI:102682
Synonyms
Lgl1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:60699723-60714186 bp, + strand
From VEGA annotation of GRCm38

  14464 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lethal(2) giant larvae protein homolog 1/2
Gene Tree: Llgl1

Human
homologs
Human Homolog LLGL1, lethal giant larvae homolog 1 (Drosophila)
NCBI Gene ID 3996
neXtProt AC  NX_Q15334
Human Synonyms  DLG4, HUGL, HUGL1, HUGL-1, LLGL
Human Chr (Location)  17p11.2; chr17:18225593-18244875 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Genomic Mutations involving Llgl1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die neonatally exhibiting hydroencephaly. Neural progenitor cell physiology is abnormal, resulting in a loss of cell polarity and the development of neuroepithelial rosette-like structures throughout the brain.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Llgl1 interacts with 145 markers (Mir1b, Mir15a, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process axonogenesis, brain development, ...
Component axon, cell projection, ...
Function protein kinase binding, Rab GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (149)    Tissues (140)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 149
cDNA source data(168)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(180) Genomic(10) cDNA(168) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000007769 (Evidence)
Ensembl Gene ModelENSMUSG00000020536 (Evidence)
Entrez Gene16897 (Evidence)
UniGene285453
DFCITC1760049, TC1586213, TC1573082
NIA Mouse Gene IndexU012701
Consensus CDS ProjectCCDS48812.1, CCDS48813.1
International Mouse Knockout Project StatusLlgl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007769 VEGA Gene Model | MGI Sequence Detail 14464 C57BL/6J ±  kb
transcript OTTMUST00000017739 VEGA | MGI Sequence Detail 4303 Not Applicable 
polypeptide OTTMUSP00000008173 VEGA | MGI Sequence Detail 1062 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000664 Lethal(2) giant larvae protein
InterPro IPR013577 Lethal giant larvae homologue 2
InterPro IPR013905 Lethal giant larvae (Lgl)-like, C-terminal
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000009847 lethal(2) giant larvae protein homolog 1
References
(Earliest) J:14430 Tomotsune D, et al., A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo. Nature. 1993 Sep 2;365(6441):69-72
(Latest) J:212706 Hawkins ED, et al., Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia. PLoS One. 2014;9(1):e87376
All references(50)
Other
accession IDs
MGD-MRK-19585, MGI:2144129

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory