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Crym
Gene Detail
Symbol

Name
ID
Crym
crystallin, mu
MGI:102675
Feature Type
protein coding gene
Genetic Map
Chromosome 7
64.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:120186380-120202111 bp, - strand
From VEGA annotation of GRCm38

  15732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ornithine cyclodeaminase
Gene Tree: Crym

Human
homologs
Human Homolog CRYM, crystallin, mu
NCBI Gene ID 1428
neXtProt AC  NX_Q14894
Human Synonyms  DFNA40, THBP
Human Chr (Location)  16p12.2; chr16:21258518-21303083 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
At the euthyroid state, homozygotes display a normal growth curve, heart rate and hearing ability but have significantly reduced serum concentrations of triiodothyronine (T3) and thyroxine (T4).
 
Interactions
Crym interacts with 35 markers (Mir29b-1, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process mitochondrial transport, negative regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, cytosol, ...
Function hormone binding, NADP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (326)    Tissues (149)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 321
RT-PCR 5
cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(38) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027354 (Evidence)
Ensembl Gene ModelENSMUSG00000030905 (Evidence)
Entrez Gene12971 (Evidence)
UniGene9114
DFCITC1578251
DoTSDT.110993035, DT.490911
NIA Mouse Gene IndexU029192
EC1.5.1.25
PDB4BVA, 4BV8, 4BV9
Consensus CDS ProjectCCDS21794.1
International Mouse Knockout Project StatusCrym
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027354 VEGA Gene Model | MGI Sequence Detail 15732 C57BL/6J ±  kb
transcript OTTMUST00000067644 VEGA | MGI Sequence Detail 1383 Not Applicable 
polypeptide OTTMUSP00000034067 VEGA | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR003462 Ornithine cyclodeaminase/mu-crystallin
InterPro IPR023401 Ornithine cyclodeaminase, N-terminal
Protein Ontology PR:000005921 thiomorpholine-carboxylate dehydrogenase
References
(Earliest) J:3554 Chen H, et al., Localization of the human gene for mu-crystallin to chromosome 16p. Genomics. 1992 Dec;14(4):1115-6
(Latest) J:201184 Ferrara AM, et al., Changes in thyroid status during perinatal development of MCT8-deficient male mice. Endocrinology. 2013 Jul;154(7):2533-41
All references(63)
Other
accession IDs
MGD-MRK-19578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory