Ddx4
Gene Detail

Symbol

Name
ID

Ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
MGI:102670

Synonyms

Mvh, mvh / m'vasa, VASA

Feature Type

protein coding gene

Genetic Map

Chromosome 13
63.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr13:112598333-112652310 bp, - strand From Ensembl annotation of GRCm38   53978 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:49227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ATP-dependent RNA helicase
Gene Tree: Ddx4

Human
homologs

Human Homolog		DDX4, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
NCBI Gene ID		54514
neXtProt AC		NX_Q9NQI0
Human Synonyms		VASA
Human Chr (Location)		5p15.2-p13.1; chr5:55738017-55817147 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.

 

Interactions

Ddx4 interacts with 164 markers (Mir7-2, Mir7b, Mir17, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (26 annotations)

Process	male meiosis I, multicellular organismal development, ...
Component	chromatoid body, cytoplasm, ...
Function	ATP binding, helicase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (140 records)

Data Summary: Results (135)    Tissues (50)    Images (76)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	68
RNA in situ	10
Northern blot	5
Western blot	18
RT-PCR	34

cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(30) cDNA(22) Primer pair(7) Other(1)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000021758 (Evidence)
Entrez Gene	13206 (Evidence)
UniGene	12818
DFCI	TC1627773, TC1581542
DoTS	DT.99849509, DT.55100412
NIA Mouse Gene Index	U035180
EC	3.6.4.13
Consensus CDS Project	CCDS26774.1, CCDS49366.1
International Mouse Knockout Project Status	Ddx4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021758	Ensembl Gene Model | MGI Sequence Detail	53978	C57BL/6J
transcript	ENSMUST00000099166	Ensembl | MGI Sequence Detail	2849	Not Applicable
polypeptide	ENSMUSP00000096769	Ensembl | MGI Sequence Detail	728	Not Applicable

All sequences(40) RefSeq(16) UniProt(2)

Polymorphisms

PCR(1) : SNPs within 2kb(522 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR000629	RNA helicase, ATP-dependent, DEAD-box, conserved site
InterPro	IPR014014	RNA helicase, DEAD-box type, Q motif
Protein Ontology	PR:000031218	ATP-dependent RNA helicase DDX4

References

(Earliest) J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
(Latest) J:217384 Suzuki A, et al., Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells. Biol Open. 2014;3(12):1207-16
All references(187)

Other
accession IDs

MGD-MRK-19572, MGI:2145395