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Ddx4 Gene Detail
Summary
  • Symbol
    Ddx4
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
  • Synonyms
    Mvh, mvh / m'vasa, VASA
  • Feature Type
    protein coding gene
  • IDs
    MGI:102670
    NCBI Gene: 13206
  • Gene Overview
    MyGene.info: DDX4
Location & Maps
more
  • Sequence Map
    Chr13:112598333-112652310 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      53978 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.87 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    DDX4, DEAD-box helicase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX4, DEAD-box helicase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VASA
  • Links
    NCBI Gene ID: 54514
    neXtProt AC: NX_Q9NQI0

  • Chr Location
    5p15.2-p13.1; chr5:55737995-55817147 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    149
  • Tissues
    53
  • cDNA Data
    21
  • Literature Summary
    164
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021758 Ensembl Gene Model | MGI Sequence Detail 53978 C57BL/6J ±  kb
transcript ENSMUST00000099166 Ensembl | MGI Sequence Detail 2849 Not Applicable  
polypeptide ENSMUSP00000096769 Ensembl | MGI Sequence Detail 728 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    521 from dbSNP Build 142
  • PCR
    1
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031218 ATP-dependent RNA helicase DDX4
  • EC
    3.6.4.13
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 31
    cDNA 22
    Primer pair 8
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19572, MGI:2145395
References
more
  • Summaries
    All 208
    Developmental Gene Expression 164
    Gene Ontology 20
    Phenotypes 13
  • Earliest
    J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
  • Latest
    J:232924 Vaithiyanathan K, et al., BCL2-modifying factor promotes germ cell loss during murine oogenesis. Reproduction. 2016 May;151(5):553-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory