Ddx4 MGI Mouse Gene Detail - MGI:102670

Symbol

Ddx4
Name

DEAD box helicase 4
Synonyms

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4, Mvh, mvh / m'vasa, VASA

Feature Type

protein coding gene
IDs

MGI:102670
NCBI Gene: 13206
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:112734867-112789009 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.87 cM
Mapping Data

6 experiments

SNPs within 2kb

516 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102670	protein coding gene	Chr13:112734867-112790342 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020938	protein coding gene	Chr13:115161415-115215891 (-)
A/J	MGP_AJ_G0020888	protein coding gene	Chr13:110566710-110622157 (-)
AKR/J	MGP_AKRJ_G0020863	protein coding gene	Chr13:113908670-113963063 (-)
BALB/cJ	MGP_BALBcJ_G0020888	protein coding gene	Chr13:111268798-111322894 (-)
C3H/HeJ	MGP_C3HHeJ_G0020677	protein coding gene	Chr13:113705208-113760159 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021324	protein coding gene	Chr13:118595648-118652660 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018893	protein coding gene	Chr13:105865413-105918233 (-)
CAST/EiJ	MGP_CASTEiJ_G0020197	protein coding gene	Chr13:113317753-113376338 (-)
CBA/J	MGP_CBAJ_G0020639	protein coding gene	Chr13:123173257-123233755 (-)
DBA/2J	MGP_DBA2J_G0020762	protein coding gene	Chr13:110282883-110337500 (-)
FVB/NJ	MGP_FVBNJ_G0020746	protein coding gene	Chr13:108973279-109029763 (-)
LP/J	MGP_LPJ_G0020838	protein coding gene	Chr13:115209346-115268470 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020774	protein coding gene	Chr13:123447966-123504680 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021360	protein coding gene	Chr13:113357491-113412730 (-)
PWK/PhJ	MGP_PWKPhJ_G0019950	protein coding gene	Chr13:109018993-109074331 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019772	protein coding gene	Chr13:109686218-109739953 (-)
WSB/EiJ	MGP_WSBEiJ_G0020254	protein coding gene	Chr13:113963339-114019292 (-)

Human Ortholog

DDX4, DEAD-box helicase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX4, DEAD-box helicase 4
Synonyms

VASA
Links

HGNC:18700

NCBI Gene ID: 54514

neXtProt AC: NX_Q9NQI0

UniProt: Q9NQI0
Chr Location

5q11.2; chr5:55737994-55817146 (+) GRCh38.p7

Alliance of Genome Resources

Ddx4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX4
Gene Tree

Ddx4

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

2
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

2

Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.

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All GO Annotations

49
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1148
Tissues

77
cDNA Data

22
Literature Summary

277

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DDX4

Xenbase ddx4

ZFIN ddx4

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Ddx4 interacts with 164 markers (Mir7-2, Mir7b, Mir17, ...) View All

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All Sequences

51
RefSeq

14
UniProt

2
CCDS

CCDS26774.1, CCDS49366.1

Ensembl

ENSMUSG00000021758 (Evidence)
NCBI Gene

13206

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000021758	Ensembl Gene Model \| MGI Sequence Detail	54143	C57BL/6J	± kb

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UniProt

2 Sequences
Protein Ontology

PR:000031218 probable ATP-dependent RNA helicase DDX4

(term hierarchy)
PDB

5JIU
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

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All nucleic 38

cDNA 23

Primer pair 13

Other 2

Microarray probesets 4

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MGD-MRK-19572, MGI:2145395

Summaries

All 334

Developmental Gene Expression 277

Gene Ontology 24

Phenotypes 23
Earliest

J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
Latest

J:320185 Windley SP, et al., Loss of NEDD4 causes complete XY gonadal sex reversal in mice. Cell Death Dis. 2022 Jan 24;13(1):75

TSS for Ddx4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124073	Chr13:112788891-112788904 (-)	111 bp
Tssr124072	Chr13:112788829-112788889 (-)	150 bp
Tssr124071	Chr13:112788803-112788810 (-)	202 bp
Tssr124070	Chr13:112788775-112788789 (-)	227 bp
Tssr124069	Chr13:112787951-112787955 (-)	1,056 bp
Tssr124068	Chr13:112757271-112757280 (-)	31,733 bp
Tssr124067	Chr13:112757246-112757254 (-)	31,759 bp
Tssr124066	Chr13:112757210-112757217 (-)	31,795 bp
Tssr124065	Chr13:112738333-112738353 (-)	50,666 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/10/2022 MGI 6.19