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Ddx4 Gene Detail
Summary
  • Symbol
    Ddx4
  • Name
    DEAD box helicase 4
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 4, Mvh, mvh / m'vasa, VASA
  • Feature Type
    protein coding gene
  • IDs
    MGI:102670
    NCBI Gene: 13206
  • Gene Overview
    MyGene.info: DDX4
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:112598333-112652475 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.87 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102670
 protein coding gene Chr13:112598333-112652633 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020938
 protein coding gene Chr13:115161415-115215891 (-)
A/J MGP_AJ_G0020888
 protein coding gene Chr13:110566710-110622157 (-)
AKR/J MGP_AKRJ_G0020863
 protein coding gene Chr13:113908670-113963063 (-)
BALB/cJ MGP_BALBcJ_G0020888
 protein coding gene Chr13:111268798-111322894 (-)
C3H/HeJ MGP_C3HHeJ_G0020677
 protein coding gene Chr13:113705208-113760159 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021324
 protein coding gene Chr13:118595648-118652660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018893
 protein coding gene Chr13:105865413-105918233 (-)
CAST/EiJ MGP_CASTEiJ_G0020197
 protein coding gene Chr13:113317753-113376338 (-)
CBA/J MGP_CBAJ_G0020639
 protein coding gene Chr13:123173257-123233755 (-)
DBA/2J MGP_DBA2J_G0020762
 protein coding gene Chr13:110282883-110337500 (-)
FVB/NJ MGP_FVBNJ_G0020746
 protein coding gene Chr13:108973279-109029763 (-)
LP/J MGP_LPJ_G0020838
 protein coding gene Chr13:115209346-115268470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020774
 protein coding gene Chr13:123447966-123504680 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021360
 protein coding gene Chr13:113357491-113412730 (-)
PWK/PhJ MGP_PWKPhJ_G0019950
 protein coding gene Chr13:109018993-109074331 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019772
 protein coding gene Chr13:109686218-109739953 (-)
WSB/EiJ MGP_WSBEiJ_G0020254
 protein coding gene Chr13:113963339-114019292 (-)



Homology
more
  • Human Ortholog
    DDX4, DEAD-box helicase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX4, DEAD-box helicase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VASA
  • Links
    NCBI Gene ID: 54514
    neXtProt AC: NX_Q9NQI0
    UniProt: Q9NQI0

  • Chr Location
    5q11.2; chr5:55737994-55817146 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    65
  • cDNA Data
    22
  • Literature Summary
    241
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021758 Ensembl Gene Model | MGI Sequence Detail 54143 C57BL/6J ±  kb
    transcript ENSMUST00000099166 Ensembl | MGI Sequence Detail 3012 Not Applicable  
    polypeptide ENSMUSP00000096769 Ensembl | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 23
      Primer pair 13
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19572, MGI:2145395
    References
    more
    • Summaries
      All 295
      Developmental Gene Expression 241
      Gene Ontology 24
      Phenotypes 21
    • Earliest
      J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
    • Latest
      J:297097 Sorrenti M, et al., Expression and possible roles of extracellular signal-related kinases 1-2 (ERK1-2) in mouse primordial germ cell development. J Reprod Dev. 2020 Oct 13;66(5):399-409
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    01/12/2021
    MGI 6.16     		The Jackson Laboratory