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Ddx4
Gene Detail
Symbol

Name
ID
Ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
MGI:102670
Synonyms
Mvh, mvh / m'vasa, VASA
Feature Type
protein coding gene
Genetic Map
Chromosome 13
63.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr13:112598333-112652310 bp, - strand
From Ensembl annotation of GRCm38

  53978 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DDX4
Protein SuperFamily: ATP-dependent RNA helicase
Gene Tree: Ddx4

Human
homologs
DDX4, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54514
neXtProt AC: NX_Q9NQI0

Human Synonyms: VASA

Human Chr (Location): 5p15.2-p13.1; chr5:55737995-55817147 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.
 
Interactions
Ddx4 interacts with 164 markers (Mir7-2, Mir7b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process male meiosis I, multicellular organismal development, ...
Component chromatoid body, cytoplasm, ...
Function ATP binding, ATP-dependent RNA helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (144 records)
Data Summary: Results (137)    Tissues (50)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 68
RNA in situ 10
Northern blot 5
Western blot 18
RT-PCR 36
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DDX4 ; Xenbase ddx4 ; ZFIN ddx4    NEW 
Molecular
reagents
All nucleic(31) cDNA(22) Primer pair(8) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021758 (Evidence)
Entrez Gene 13206 (Evidence)
UniGene 12818
DFCI TC1627773, TC1581542
DoTS DT.55100412, DT.99849509
NIA Mouse Gene Index U035180
EC 3.6.4.13
Consensus CDS Project CCDS26774.1, CCDS49366.1
International Mouse Phenotyping Consortium Status Ddx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021758 Ensembl Gene Model | MGI Sequence Detail 53978 C57BL/6J ±  kb
transcript ENSMUST00000099166 Ensembl | MGI Sequence Detail 2849 Not Applicable 
polypeptide ENSMUSP00000096769 Ensembl | MGI Sequence Detail 728 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(16) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(522 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000629 RNA helicase, ATP-dependent, DEAD-box, conserved site
InterPro IPR014014 RNA helicase, DEAD-box type, Q motif
Protein Ontology PR:000031218 ATP-dependent RNA helicase DDX4
References
(Earliest) J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
(Latest) J:219506 Kim S, et al., PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014 Nov 20;56(4):564-79
All references(191)
Other
accession IDs
MGD-MRK-19572, MGI:2145395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory