Ddx4 MGI Mouse Gene Detail - MGI:102670 - DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Ddx4 Gene Detail

Symbol

Ddx4
Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Synonyms

Mvh, mvh / m'vasa, VASA

Feature Type

protein coding gene
IDs

MGI:102670
NCBI Gene: 13206
Gene Overview

MyGene.info: DDX4

Sequence Map

Chr13:112598333-112652310 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

53978 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.87 cM
Mapping Data

6 experiments

Human Ortholog

DDX4, DEAD-box helicase 4

Vertebrate Orthologs

10

Human Ortholog

DDX4, DEAD-box helicase 4
Orthology source: HomoloGene, HGNC
Synonyms

VASA
Links

HGNC:18700

NCBI Gene ID: 54514

neXtProt AC: NX_Q9NQI0

UniProt: Q9NQI0
Chr Location

5q11.2; chr5:55737994-55817146 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 49227
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DDX4
Protein SuperFamily

ATP-dependent RNA helicase
Gene Tree

Ddx4

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available

Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.

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All GO Annotations

36
GO References

20

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

168
Tissues

57
cDNA Data

21
Literature Summary

175

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DDX4

Xenbase ddx4

ZFIN ddx4

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Ddx4 interacts with 164 markers (Mir7-2, Mir7b, Mir17, ...) View All

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All Sequences

33
RefSeq

14
UniProt

2
CCDS

CCDS26774.1, CCDS49366.1
UniGene

12818

Ensembl

ENSMUSG00000021758 (Evidence)
NCBI Gene

13206

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021758	Ensembl Gene Model \| MGI Sequence Detail	53978	C57BL/6J	± kb
transcript	ENSMUST00000099166	Ensembl \| MGI Sequence Detail	2849	Not Applicable
polypeptide	ENSMUSP00000096769	Ensembl \| MGI Sequence Detail	728	Not Applicable

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SNPs within 2kb

521 from dbSNP Build 142

PCR

1

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UniProt

2 Sequences
Protein Ontology

PR:000031218 ATP-dependent RNA helicase DDX4

(term hierarchy)
PDB

5JIU
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

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All nucleic 31

cDNA 22

Primer pair 8

Other 1

Microarray probesets 4

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MGD-MRK-19572, MGI:2145395

Summaries

All 219

Developmental Gene Expression 175

Gene Ontology 20

Phenotypes 13
Earliest

J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
Latest

J:240405 Zhao L, et al., SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice. Dev Biol. 2017 Mar 01;423(1):46-56

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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