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Ddx4 Gene Detail
Summary
  • Symbol
    Ddx4
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
  • Synonyms
    Mvh, mvh / m'vasa, VASA
  • Feature Type
    protein coding gene
  • IDs
    MGI:102670
    NCBI Gene: 13206
  • Gene Overview
    MyGene.info: DDX4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr13:112598333-112652475 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      54143 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.87 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    DDX4, DEAD-box helicase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX4, DEAD-box helicase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VASA
  • Links
    NCBI Gene ID: 54514
    neXtProt AC: NX_Q9NQI0
    UniProt: Q9NQI0

  • Chr Location
    5q11.2; chr5:55737994-55817146 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    200
  • Tissues
    59
  • cDNA Data
    21
  • Literature Summary
    196
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021758 Ensembl Gene Model | MGI Sequence Detail 54143 C57BL/6J ±  kb
    transcript ENSMUST00000099166 Ensembl | MGI Sequence Detail 3012 Not Applicable  
    polypeptide ENSMUSP00000096769 Ensembl | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      521 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
      5JIU
    • EC
      3.6.4.13
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR011545 DEAD/DEAH box helicase domain
      IPR001650 Helicase, C-terminal
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 22
      Primer pair 10
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19572, MGI:2145395
    References
    more
    • Summaries
      All 243
      Developmental Gene Expression 196
      Gene Ontology 24
      Phenotypes 16
    • Earliest
      J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
    • Latest
      J:261014 Yoshimura T, et al., Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. EMBO Rep. 2018 Apr;19(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory