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Kcnd2 Gene Detail
Summary
  • Symbol
    Kcnd2
  • Name
    potassium voltage-gated channel, Shal-related family, member 2
  • Synonyms
    Kv4.2, mKIAA1044
  • Feature Type
    protein coding gene
  • IDs
    MGI:102663
    NCBI Gene: 16508
  • Gene Overview
    MyGene.info: KCND2
Location & Maps
more
  • Sequence Map
    Chr6:21215503-21729805 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      514303 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KCND2, potassium voltage-gated channel subfamily D member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCND2, potassium voltage-gated channel subfamily D member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KV4.2, RK5
  • Links
    NCBI Gene ID: 3751
    neXtProt AC: NX_Q9NZV8

  • Chr Location
    7q31; chr7:120273641-120750333 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Homozygous mutation of this gene reduces A-type currents in spinal cord dorsal horn neurons and increases their excitability, resulting in enhanced sensitivity to tactile and thermal stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036888 VEGA Gene Model | MGI Sequence Detail 514303 C57BL/6J ±  kb
transcript OTTMUST00000094768 VEGA | MGI Sequence Detail 5152 Not Applicable  
polypeptide OTTMUSP00000052780 VEGA | MGI Sequence Detail 630 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2772 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000000785 voltage-gated potassium channel KCND2
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003975 Potassium channel, voltage dependent, Kv4
    IPR004055 Potassium channel, voltage dependent, Kv4.2
    IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
    IPR021645 Shal-type voltage-gated potassium channels, N-terminal
    IPR011333 SKP1/BTB/POZ domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
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  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-19563, MGI:2141480, MGI:2141704, MGI:2141795
References
more
  • Summaries
    All 82
    Developmental Gene Expression 14
    Gene Ontology 13
    Phenotypes 26
  • Earliest
    J:16150 Klocke R, et al., Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. Genomics. 1993 Dec;18(3):568-74
  • Latest
    J:226616 Araujo DJ, et al., FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes Dev. 2015 Oct 15;29(20):2081-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory