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Kcnd2 Gene Detail
Summary
  • Symbol
    Kcnd2
  • Name
    potassium voltage-gated channel, Shal-related family, member 2
  • Synonyms
    Kv4.2, mKIAA1044
  • Feature Type
    protein coding gene
  • IDs
    MGI:102663
    NCBI Gene: 16508
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:21215502-21729804 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 8.49 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2772 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102663
protein coding gene Chr6:21212101-21729804 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030479
protein coding gene Chr6:18646521-19192891 (+)
A/J MGP_AJ_G0030452
protein coding gene Chr6:17886602-18406499 (+)
AKR/J MGP_AKRJ_G0030379
protein coding gene Chr6:18441811-18960948 (+)
BALB/cJ MGP_BALBcJ_G0030461
protein coding gene Chr6:17958053-18489263 (+)
C3H/HeJ MGP_C3HHeJ_G0030175
protein coding gene Chr6:18392052-18938438 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030916
protein coding gene Chr6:19226110-19781630 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028127
protein coding gene Chr6:16544706-17039753 (+)
CAST/EiJ MGP_CASTEiJ_G0029577
protein coding gene Chr6:18337306-18881081 (+)
CBA/J MGP_CBAJ_G0030153
protein coding gene Chr6:19844124-20436733 (+)
DBA/2J MGP_DBA2J_G0030297
protein coding gene Chr6:17801859-18315301 (+)
FVB/NJ MGP_FVBNJ_G0030251
protein coding gene Chr6:17592001-18107133 (+)
LP/J MGP_LPJ_G0030384
protein coding gene Chr6:18749920-19292462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030287
protein coding gene Chr6:21634862-22257975 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030946
protein coding gene Chr6:18392663-18941195 (+)
PWK/PhJ MGP_PWKPhJ_G0029291
protein coding gene Chr6:17461880-17991609 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029127
protein coding gene Chr6:18173229-18705672 (+)
WSB/EiJ MGP_WSBEiJ_G0029653
protein coding gene Chr6:18292307-18824377 (+)



Homology
more
  • Human Ortholog
    KCND2, potassium voltage-gated channel subfamily D member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCND2, potassium voltage-gated channel subfamily D member 2
  • Synonyms
    KV4.2, RK5
  • Links
    NCBI Gene ID: 3751
    neXtProt AC: NX_Q9NZV8
    UniProt: Q9NZV8

  • Chr Location
    7q31.31; chr7:120272908-120750337 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene reduces A-type currents in spinal cord dorsal horn neurons and increases their excitability, resulting in enhanced sensitivity to tactile and thermal stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060882 Ensembl Gene Model | MGI Sequence Detail 514303 C57BL/6J ±  kb
transcript ENSMUST00000081542 Ensembl | MGI Sequence Detail 5152 Not Applicable  
polypeptide ENSMUSP00000080257 Ensembl | MGI Sequence Detail 630 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000000785 voltage-gated potassium channel KCND2
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003975 Potassium channel, voltage dependent, Kv4
    IPR004055 Potassium channel, voltage dependent, Kv4.2
    IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
    IPR021645 Shal-type voltage-gated potassium channels, N-terminal
    IPR011333 SKP1/BTB/POZ domain superfamily
    IPR027359 Voltage-dependent channel domain superfamily
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-19563, MGI:2141480, MGI:2141704, MGI:2141795
References
more
  • Summaries
    All 115
    Developmental Gene Expression 26
    Gene Ontology 17
    Phenotypes 38
  • Earliest
    J:16150 Klocke R, et al., Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. Genomics. 1993 Dec;18(3):568-74
  • Latest
    J:325724 Gong Y, et al., Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia. Cells. 2022 Jun 4;11(11)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory