Kcnd2
Gene Detail

Symbol Name ID

Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 MGI:102663

Synonyms

Kv4.2, mKIAA1044

Feature Type

protein coding gene

Genetic Map

Chromosome 6

8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:21215503-21729805 bp, + strand From VEGA annotation of GRCm38   514303 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnd2

Human homologs

Human Homolog		KCND2, potassium voltage-gated channel, Shal-related subfamily, member 2
NCBI Gene ID		3751
neXtProt AC		NX_Q9NZV8
Human Synonyms		KV4.2, RK5
Human Chr (Location)		7q31; chr7:119913722-120390387 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous mutation of this gene reduces A-type currents in spinal cord dorsal horn neurons and increases their excitability, resulting in enhanced sensitivity to tactile and thermal stimuli.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	cell projection, cell surface, ...
Function	A-type (transient outward) potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (235)    Tissues (31)    Images (23)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	223
RT-PCR	12

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000036888 (Evidence)
Ensembl Gene Model	ENSMUSG00000060882 (Evidence)
Entrez Gene	16508 (Evidence)
DFCI	TC1582771, TC1591144
DoTS	DT.55198772
NIA Mouse Gene Index	U006580
Consensus CDS Project	CCDS19934.1
International Mouse Knockout Project Status	Kcnd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036888	VEGA Gene Model | MGI Sequence Detail	514303	C57BL/6J
transcript	OTTMUST00000094768	VEGA | MGI Sequence Detail	5152	Not Applicable
polypeptide	OTTMUSP00000052780	VEGA | MGI Sequence Detail	630	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(2061 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003975	Potassium channel, voltage dependent, Kv4
InterPro	IPR004055	Potassium channel, voltage dependent, Kv4.2
InterPro	IPR024587	Potassium channel, voltage dependent, Kv4, C-terminal
InterPro	IPR021645	Shal-type voltage-gated potassium channels
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000785	voltage-gated potassium channel KCND2

References

(Earliest) J:16150 Klocke R, et al., Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. Genomics. 1993 Dec;18(3):568-74
(Latest) J:192291 Murase S, et al., Loss of signal transducer and activator of transcription 3 (STAT3) signaling during elevated activity causes vulnerability in hippocampal neurons. J Neurosci. 2012 Oct 31;32(44):15511-20
All references(71)

Other accession IDs

MGD-MRK-19563, MGI:2141480, MGI:2141704, MGI:2141795