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Kcnd2
Gene Detail
 Symbol
Name
ID
Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
MGI:102663
Synonyms Kv4.2, mKIAA1044
Feature Type protein coding gene
Genetic Map
Chromosome 6
8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:21215503-21729805 bp, + strand
From VEGA annotation of GRCm38

  514303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnd2

Human
homologs
Human Homolog KCND2, potassium voltage-gated channel, Shal-related subfamily, member 2
NCBI Gene ID 3751
neXtProt AC  NX_Q9NZV8
Human Synonyms  KV4.2, RK5
Human Chr (Location)  7q31; chr7:120273635-120750333 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene reduces A-type currents in spinal cord dorsal horn neurons and increases their excitability, resulting in enhanced sensitivity to tactile and thermal stimuli.
 
Interactions
Kcnd2 interacts with 381 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process action potential, ion transport, ...
Component cell projection, dendrite, ...
Function A-type (transient outward) potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (278)    Tissues (76)    Images (25)
Theiler Stages: 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 266
RT-PCR 12
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000036888 (Evidence)
Ensembl Gene ModelENSMUSG00000060882 (Evidence)
Entrez Gene16508 (Evidence)
UniGene425316
DFCITC1582771, TC1591144
DoTSDT.55198772
NIA Mouse Gene IndexU006580
Consensus CDS ProjectCCDS19934.1
International Mouse Knockout Project StatusKcnd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036888 VEGA Gene Model | MGI Sequence Detail 514303 C57BL/6J ±  kb
transcript OTTMUST00000094768 VEGA | MGI Sequence Detail 5152 Not Applicable 
polypeptide OTTMUSP00000052780 VEGA | MGI Sequence Detail 630 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(2783 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2785)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003975 Potassium channel, voltage dependent, Kv4
InterPro IPR004055 Potassium channel, voltage dependent, Kv4.2
InterPro IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
InterPro IPR021645 Shal-type voltage-gated potassium channels
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000785 voltage-gated potassium channel KCND2
References (Earliest) J:16150 Klocke R, et al., Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. Genomics. 1993 Dec;18(3):568-74
(Latest) J:207227 Mercer RC, et al., The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013 Dec 27;288(52):37241-55
All references(78)
Other
accession IDs
MGD-MRK-19563, MGI:2141480, MGI:2141704, MGI:2141795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory