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Rdh11 Gene Detail
Summary
  • Symbol
    Rdh11
  • Name
    retinol dehydrogenase 11
  • Synonyms
    2610319N22Rik, Arsdr1, M42C60, Mdt1, Psdr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102581
    NCBI Gene: 17252
  • Gene Overview
    MyGene.info: RDH11
Location & Maps
more
  • Sequence Map
    Chr12:79174337-79192293 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RDH11, retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RDH11, retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
    Orthology source: HomoloGene
  • Synonyms
    ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, RDJCSS, SCALD, SDR7C1
  • Links
    NCBI Gene ID: 51109
    neXtProt AC: NX_Q8TC12

  • Chr Location
    14q24.1; chr14:67676800-67695793 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RDH11 associations

Human Disease Mouse Models
       Retinal Dystrophy, Juvenile Cataracts, and Short Stature Syndrome;   OMIM: 616108
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Rdh11
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene exhibit delayed dark adaptation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034945 VEGA Gene Model | MGI Sequence Detail 17957 C57BL/6J ±  kb
transcript OTTMUST00000088844 VEGA | MGI Sequence Detail 3262 Not Applicable  
polypeptide OTTMUSP00000048482 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    99 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 103
    cDNA 102
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19467, MGI:1914425, MGI:2144817, MGI:2144969, MGI:2145121
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
  • Latest
    J:214109 Adams MK, et al., The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014 May 23;289(21):14868-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory