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Rdh11 Gene Detail
Summary
  • Symbol
    Rdh11
  • Name
    retinol dehydrogenase 11
  • Synonyms
    2610319N22Rik, Arsdr1, M42C60, Mdt1, Psdr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102581
    NCBI Gene: 17252
  • Gene Overview
    MyGene.info: RDH11
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:79175551-79191819 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102581
protein coding gene Chr12:79174337-79192293 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019881
protein coding gene Chr12:79454522-79474836 (-)
A/J MGP_AJ_G0019839
protein coding gene Chr12:76599918-76618735 (-)
AKR/J MGP_AKRJ_G0019814
protein coding gene Chr12:78672835-78690689 (-)
BALB/cJ MGP_BALBcJ_G0019818
protein coding gene Chr12:76853803-76872031 (-)
C3H/HeJ MGP_C3HHeJ_G0019624
protein coding gene Chr12:79151123-79170060 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020270
protein coding gene Chr12:81803575-81823225 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017889
protein coding gene Chr12:73616008-73634799 (-)
CAST/EiJ MGP_CASTEiJ_G0019174
protein coding gene Chr12:73982262-74001474 (-)
CBA/J MGP_CBAJ_G0019595
protein coding gene Chr12:84997970-85017216 (-)
DBA/2J MGP_DBA2J_G0019710
protein coding gene Chr12:76222861-76241376 (-)
FVB/NJ MGP_FVBNJ_G0019696
protein coding gene Chr12:75035675-75053544 (-)
LP/J MGP_LPJ_G0019782
protein coding gene Chr12:79389656-79408110 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019735
protein coding gene Chr12:88035002-88053043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020305
protein coding gene Chr12:78190422-78211680 (-)
PWK/PhJ MGP_PWKPhJ_G0018940
protein coding gene Chr12:70582806-70601821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018734
protein coding gene Chr12:72692429-72710349 (-)
WSB/EiJ MGP_WSBEiJ_G0019227
protein coding gene Chr12:78807871-78828824 (-)



Homology
more
  • Human Ortholog
    RDH11, retinol dehydrogenase 11
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RDH11, retinol dehydrogenase 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, RDJCSS, SCALD, SDR7C1
  • Links
    NCBI Gene ID: 51109
    neXtProt AC: NX_Q8TC12
    UniProt: Q8TC12

  • Chr Location
    14q24.1; chr14:67676800-67695793 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Rdh11
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for disruptions in this gene exhibit delayed dark adaptation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17252 NCBI Gene Model | MGI Sequence Detail 16269 C57BL/6J ±  kb
transcript NM_001362269 RefSeq | MGI Sequence Detail 2991 C57BL/6  
polypeptide Q9QYF1 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR036291 NAD(P)-binding domain superfamily
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
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  • All nucleic 105
    cDNA 104
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19467, MGI:1914425, MGI:2144817, MGI:2144969, MGI:2145121
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
  • Latest
    J:214109 Adams MK, et al., The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014 May 23;289(21):14868-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory