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Pou2f3
Gene Detail
Symbol

Name
ID
Pou2f3
POU domain, class 2, transcription factor 3
MGI:102565
Synonyms
Epoc-1, Oct11, Oct-11a, Otf11, Otf-11, Skin, Skin-1a, Skn-1a, Skn-li
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:43123939-43210369 bp, - strand
From VEGA annotation of GRCm38

  86431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POU2F3
Protein SuperFamily: transcription factor Oct-2
Gene Tree: Pou2f3

Human
homologs
POU2F3, POU class 2 homeobox 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 25833
neXtProt AC: NX_Q9UKI9

Human Synonyms: Epoc-1, OCT11, OCT-11, OTF-11, PLA1, PLA-1, Skn-1a

Human Chr (Location): 11q23.3; chr11:120236640-120319945 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null mutation exhibit defective keratinocyte differentiation, however the skin and coat appear normal. Mice homozygous for another null mutation display loss of sweet, umami and bitter taste perception and expansion of sour taste receptor cells.
 
Interactions
Pou2f3 interacts with 285 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process epidermis development, keratinocyte differentiation, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (52)    Tissues (52)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
RT-PCR 8
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pou2f3    NEW 
Molecular
reagents
All nucleic(17) Genomic(3) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000039872 (Evidence)
Ensembl Gene Model ENSMUSG00000032015 (Evidence)
Entrez Gene 18988 (Evidence)
UniGene 436650
DFCI TC1592790
DoTS DT.87057263, DT.55153688, DT.486825
NIA Mouse Gene Index U030756
Consensus CDS Project CCDS40596.1
International Mouse Phenotyping Consortium Status Pou2f3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039872 VEGA Gene Model | MGI Sequence Detail 86431 C57BL/6J ±  kb
transcript OTTMUST00000103600 VEGA | MGI Sequence Detail 1921 Not Applicable 
polypeptide OTTMUSP00000057901 VEGA | MGI Sequence Detail 431 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(600 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR000972 Octamer-binding transcription factor
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013037 POU domain, class 2, transcription factor 3
References
(Earliest) J:10430 Goldsborough A, et al., Cloning and sequencing of POU-boxes expressed in mouse testis. Nucleic Acids Res. 1990 Mar 25;18(6):1634
(Latest) J:217940 Neumann C, et al., The delta-Opioid Receptor Affects Epidermal Homeostasis via ERK-Dependent Inhibition of Transcription Factor POU2F3. J Invest Dermatol. 2015 Feb;135(2):471-80
All references(47)
Other
accession IDs
MGD-MRK-13061, MGD-MRK-13067, MGD-MRK-16488, MGD-MRK-19442, MGD-MRK-19446

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory