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Pou2f3
Gene Detail
 Symbol
Name
ID
Pou2f3
POU domain, class 2, transcription factor 3
MGI:102565
Synonyms Epoc-1, Oct11, Oct-11a, Otf11, Otf-11, Skin, Skin-1a, Skn-1a, Skn-li
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:43123939-43210369 bp, - strand
From VEGA annotation of GRCm38

  86431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor Oct-2
Gene Tree: Pou2f3

Human
homologs
Human Homolog POU2F3, POU class 2 homeobox 3
NCBI Gene ID 25833
neXtProt AC  NX_Q9UKI9
Human Synonyms  Epoc-1, OCT11, OCT-11, OTF-11, PLA1, PLA-1, Skn-1a
Human Chr (Location)  11q23.3; chr11:120236640-120319944 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(4) Gene trapped(3)
 
Mice homozygous for one null mutation exhibit defective keratinocyte differentiation, however the skin and coat appear normal. Mice homozygous for another null mutation display loss of sweet, umami and bitter taste perception and expansion of sour taste receptor cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process epidermis development, keratinocyte differentiation, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (59)    Tissues (57)    Images (5)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28
Assay TypeResults
RNA in situ 44
RT-PCR 15
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) Genomic(3) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000039872 (Evidence)
Ensembl Gene ModelENSMUSG00000032015 (Evidence)
Entrez Gene18988 (Evidence)
UniGene436650
DFCITC1592790
DoTSDT.486825, DT.55153688, DT.87057263
NIA Mouse Gene IndexU030756
Consensus CDS ProjectCCDS40596.1
International Mouse Knockout Project StatusPou2f3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039872 VEGA Gene Model | MGI Sequence Detail 86431 C57BL/6J ±  kb
transcript OTTMUST00000103600 VEGA | MGI Sequence Detail 1590 Not Applicable 
polypeptide OTTMUSP00000057901 VEGA | MGI Sequence Detail 431 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(600 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR000972 Octamer-binding transcription factor
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013037 POU domain, class 2, transcription factor 3
References (Earliest) J:10430 Goldsborough A, et al., Cloning and sequencing of POU-boxes expressed in mouse testis. Nucleic Acids Res. 1990 Mar 25;18(6):1634
(Latest) J:173905 Matsumoto I, et al., Skn-1a (Pou2f3) specifies taste receptor cell lineage. Nat Neurosci. 2011 Jun;14(6):685-7
All references(45)
Other
accession IDs
MGD-MRK-13061, MGD-MRK-13067, MGD-MRK-16488, MGD-MRK-19442, MGD-MRK-19446

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory