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Pou2f3 Gene Detail
Summary
  • Symbol
    Pou2f3
  • Name
    POU domain, class 2, transcription factor 3
  • Synonyms
    Epoc-1, Oct11, Oct-11a, Otf11, Otf-11, Skin, Skin-1a, Skn-1a, Skn-li
  • Feature Type
    protein coding gene
  • IDs
    MGI:102565
    NCBI Gene: 18988
  • Gene Overview
    MyGene.info: POU2F3
Location & Maps
more
  • Sequence Map
    Chr9:43123939-43210369 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86431 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.21 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    POU2F3, POU class 2 homeobox 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POU2F3, POU class 2 homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Epoc-1, OCT11, OCT-11, OTF-11, PLA1, PLA-1, Skn-1a
  • Links
    NCBI Gene ID: 25833
    neXtProt AC: NX_Q9UKI9

  • Chr Location
    11q23.3; chr11:120236640-120319945 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for one null mutation exhibit defective keratinocyte differentiation, however the skin and coat appear normal. Mice homozygous for another null mutation display loss of sweet, umami and bitter taste perception and expansion of sour taste receptor cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039872 VEGA Gene Model | MGI Sequence Detail 86431 C57BL/6J ±  kb
transcript OTTMUST00000103600 VEGA | MGI Sequence Detail 1921 Not Applicable  
polypeptide OTTMUSP00000057901 VEGA | MGI Sequence Detail 431 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    597 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 17
    Genomic 3
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13061, MGD-MRK-13067, MGD-MRK-16488, MGD-MRK-19442, MGD-MRK-19446
References
more
  • Summaries
    All 46
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:10430 Goldsborough A, et al., Cloning and sequencing of POU-boxes expressed in mouse testis. Nucleic Acids Res. 1990 Mar 25;18(6):1634
  • Latest
    J:217940 Neumann C, et al., The delta-Opioid Receptor Affects Epidermal Homeostasis via ERK-Dependent Inhibition of Transcription Factor POU2F3. J Invest Dermatol. 2015 Feb;135(2):471-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory