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Pou3f3 Gene Detail
Summary
  • Symbol
    Pou3f3
  • Name
    POU domain, class 3, transcription factor 3
  • Synonyms
    Brn1, Brn-1, HST011, Otf8, urehr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102564
    NCBI Gene: 18993
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:42697146-42700210 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 21.21 cM
  • Mapping Data
    3 experiments
  • Sequence Tag
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102564
protein coding gene Chr1:42695768-42703176 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015974
protein coding gene Chr1:41644666-41653404 (+)
A/J MGP_AJ_G0015958
protein coding gene Chr1:40409808-40417360 (+)
AKR/J MGP_AKRJ_G0015913
protein coding gene Chr1:40921295-40928680 (+)
BALB/cJ MGP_BALBcJ_G0015912
protein coding gene Chr1:40068554-40076208 (+)
C3H/HeJ MGP_C3HHeJ_G0015745
protein coding gene Chr1:41300442-41308493 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016365
protein coding gene Chr1:43367639-43376020 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014087
protein coding gene Chr1:37236641-37244086 (+)
CAST/EiJ MGP_CASTEiJ_G0015326
protein coding gene Chr1:41280476-41288644 (+)
CBA/J MGP_CBAJ_G0015717
protein coding gene Chr1:44640242-44653515 (+)
DBA/2J MGP_DBA2J_G0015818
protein coding gene Chr1:39675989-39683785 (+)
FVB/NJ MGP_FVBNJ_G0015820
protein coding gene Chr1:39206861-39214059 (+)
LP/J MGP_LPJ_G0015888
protein coding gene Chr1:41987395-41994273 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015840
protein coding gene Chr1:46622640-46630617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016412
protein coding gene Chr1:41124696-41135277 (+)
PWK/PhJ MGP_PWKPhJ_G0015109
protein coding gene Chr1:39539369-39547551 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014891
protein coding gene Chr1:41124317-41132718 (+)
WSB/EiJ MGP_WSBEiJ_G0015388
protein coding gene Chr1:41164289-41174777 (+)



Homology
more
  • Human Ortholog
    POU3F3, POU class 3 homeobox 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    POU3F3, POU class 3 homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    brain-1, BRN1, oct-8, OTF8
  • Links
    NCBI Gene ID: 5455
    neXtProt AC: NX_P20264
    UniProt: P20264

  • Chr Location
    2q12.1; chr2:104854068-104858574 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in death within 36 hours after birth. Mutant brains exhibit disorganized cells in the hippocampus and adjacent transitional cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18993 NCBI Gene Model | MGI Sequence Detail 3065 C57BL/6J ±  kb
    transcript NM_008900 RefSeq | MGI Sequence Detail 3080 C57BL/6  
    polypeptide P31361 UniProt | EBI | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 13
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13083, MGD-MRK-1623, MGD-MRK-1627, MGD-MRK-19445, MGI:3712270
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 85
      Gene Ontology 13
      Phenotypes 11
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:243561 Basta JM, et al., A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation. Development. 2017 Sep 01;144(17):3080-3094

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory