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Pou3f3
Gene Detail
Symbol

Name
ID
Pou3f3
POU domain, class 3, transcription factor 3
MGI:102564
STS
Synonyms
Brn1, Brn-1, Otf8
Feature Type
protein coding gene
Genetic Map
Chromosome 1
21.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:42695768-42703176 bp, + strand
From VEGA annotation of GRCm38

  7409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: POU3F3
Protein SuperFamily: POU domain class 3 transcription factor, brain type
Gene Tree: Pou3f3

Human
homologs
POU3F3, POU class 3 homeobox 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5455
neXtProt AC: NX_P20264

Human Synonyms: brain-1, BRN1, oct-8, OTF8

Human Chr (Location): 2q12.1; chr2:104855511-104857013 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in death within 36 hours after birth. Mutant brains exhibit disorganized cells in the hippocampus and adjacent transitional cortex.
 
Interactions
Pou3f3 interacts with 213 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process brain development, cerebral cortex radially oriented cell migration, ...
Component nucleus
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (601)    Tissues (272)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 581
RT-PCR 8
cDNA source data(8)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase pou3f3 ; ZFIN pou3f3a, pou3f3b    NEW 
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(12) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022569 (Evidence)
Ensembl Gene Model ENSMUSG00000045515 (Evidence)
Entrez Gene 18993 (Evidence)
UniGene 489878
Consensus CDS Project CCDS14917.1
International Mouse Phenotyping Consortium Status Pou3f3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022569 VEGA Gene Model | MGI Sequence Detail 7409 C57BL/6J ±  kb
transcript OTTMUST00000054069 VEGA | MGI Sequence Detail 7409 Not Applicable 
polypeptide OTTMUSP00000025751 VEGA | MGI Sequence Detail 497 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(3) : SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
InterPro IPR016362 Transcription factor, homeobox/POU
Protein Ontology PR:000031407 POU domain, class 3, transcription factor 3
References
(Earliest) J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
(Latest) J:219859 Pucilowska J, et al., The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway. J Neurosci. 2015 Feb 18;35(7):3190-200
All references(100)
Other
accession IDs
MGD-MRK-13083, MGD-MRK-1623, MGD-MRK-1627, MGD-MRK-19445

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory