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Pou3f3 Gene Detail
Summary
  • Symbol
    Pou3f3
  • Name
    POU domain, class 3, transcription factor 3
  • Synonyms
    Brn1, Brn-1, Otf8
  • Feature Type
    protein coding gene
  • IDs
    MGI:102564
    NCBI Gene: 18993
Location & Maps
more
  • Sequence Map
    Chr1:42695768-42703176 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7409 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    POU3F3, POU class 3 homeobox 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    POU3F3, POU class 3 homeobox 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    brain-1, BRN1, oct-8, OTF8
  • Links
    NCBI Gene ID: 5455
    neXtProt AC: NX_P20264

  • Chr Location
    2q12.1; chr2:104855511-104857013 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Pou3f3
  • Incidental Mutations
Homozygous mutation of this gene results in death within 36 hours after birth. Mutant brains exhibit disorganized cells in the hippocampus and adjacent transitional cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022569 VEGA Gene Model | MGI Sequence Detail 7409 C57BL/6J ±  kb
transcript OTTMUST00000054069 VEGA | MGI Sequence Detail 7409 Not Applicable  
polypeptide OTTMUSP00000025751 VEGA | MGI Sequence Detail 497 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 2
    cDNA 12
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13083, MGD-MRK-1623, MGD-MRK-1627, MGD-MRK-19445
References
more
  • Summaries
    All 103
    Developmental Gene Expression 74
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
  • Latest
    J:228026 Capecchi MR, et al., ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun. 2015;6:8763

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory