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Crisp1 Gene Detail
Summary
  • Symbol
    Crisp1
  • Name
    cysteine-rich secretory protein 1
  • Synonyms
    Aeg1, CRISP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102553
    NCBI Gene: 11571
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:40293758-40319207 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102553
protein coding gene Chr17:40293758-40319243 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023753
protein coding gene Chr17:41089442-41117744 (-)
A/J MGP_AJ_G0023711
protein coding gene Chr17:40162510-40188616 (-)
AKR/J MGP_AKRJ_G0023683
protein coding gene Chr17:40247775-40292162 (-)
BALB/cJ MGP_BALBcJ_G0023714
protein coding gene Chr17:40030954-40056682 (-)
C3H/HeJ MGP_C3HHeJ_G0023480
protein coding gene Chr17:40862784-40883344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024157
protein coding gene Chr17:42909279-42932566 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021611
protein coding gene Chr17:37129490-37326678 (-)
CAST/EiJ MGP_CASTEiJ_G0022960
protein coding gene Chr17:41024667-41050829 (-)
CBA/J MGP_CBAJ_G0023456
protein coding gene Chr17:44394335-44440964 (-)
DBA/2J MGP_DBA2J_G0023581
protein coding gene Chr17:38974531-38996701 (-)
FVB/NJ MGP_FVBNJ_G0023548
protein coding gene Chr17:38567377-38608101 (-)
LP/J MGP_LPJ_G0023662
protein coding gene Chr17:41708598-41736199 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023576
protein coding gene Chr17:43771863-43823790 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024203
protein coding gene Chr17:40638399-40660579 (-)
PWK/PhJ MGP_PWKPhJ_G0022704
protein coding gene Chr17:38327207-38350002 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022522
protein coding gene Chr17:37801864-37825644 (-)
WSB/EiJ MGP_WSBEiJ_G0023025
protein coding gene Chr17:41049074-41105497 (-)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced ability of sperm to fertilize eggs but no reduction in fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025431 Ensembl Gene Model | MGI Sequence Detail 25450 C57BL/6J ±  kb
transcript ENSMUST00000026498 Ensembl | MGI Sequence Detail 1416 Not Applicable  
polypeptide ENSMUSP00000026498 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR018244 Allergen V5/Tpx-1-related, conserved site
    IPR014044 CAP domain
    IPR035940 CAP superfamily
    IPR013871 Cysteine-rich secretory protein
    IPR001283 Cysteine-rich secretory protein, allergen V5/Tpx-1-related
    IPR034117 Cysteine-rich secretory protein, SCP domain
    IPR003582 ShKT domain
Molecular
Reagents
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  • All nucleic 24
    Genomic 4
    cDNA 18
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19402, MGI:2147060
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:3169 Mizuki N, et al., Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule. Mol Cell Endocrinol. 1992 Nov;89(1-2):25-32
  • Latest
    J:264552 Weigel Munoz M, et al., Influence of the genetic background on the reproductive phenotype of mice lacking Cysteine-Rich Secretory Protein 1 (CRISP1). Biol Reprod. 2018 Aug 1;99(2):373-383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory