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Ccnf
Gene Detail
Symbol

Name
ID
Ccnf
cyclin F
MGI:102551
Synonyms
CycF, Fbxo1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:24223232-24251409 bp, - strand
From Ensembl annotation of GRCm38

  28178 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1335  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCNF
Gene Tree: Ccnf

Human
homologs
CCNF, cyclin F
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 899
neXtProt AC: NX_P41002

Human Synonyms: FBX1, FBXO1

Human Chr (Location): 16p13.3; chr16:2429394-2458858 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(29) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in embryonic lethality between E9.5 and E10.5 due to defects in yolk sac and chorioallantoic placenta maturation. Embryos show incomplete turning, underdeveloped posterior structures, neural tube closure and brain defects. MEFs have cell cycle defects.
 
Interactions
Ccnf interacts with 131 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell cycle, cell division, ...
Component centriole, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (58)    Tissues (5)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 56
Western blot 2
cDNA source data(110)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ccnf ; ZFIN ccnf    NEW 
Molecular
reagents
All nucleic(112) Genomic(1) cDNA(111)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000072082 (Evidence)
Entrez Gene 12449 (Evidence)
UniGene 77695
DFCI TC1595326, TC1574117
DoTS DT.101741277, DT.99861898, DT.101403707, DT.101403705, DT.97374823, DT.531985, DT.94262689, DT.91281256
NIA Mouse Gene Index U037522
Consensus CDS Project CCDS37484.1
International Mouse Phenotyping Consortium Status Ccnf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072082 Ensembl Gene Model | MGI Sequence Detail 28178 C57BL/6J ±  kb
transcript ENSMUST00000115390 Ensembl | MGI Sequence Detail 3099 Not Applicable 
polypeptide ENSMUSP00000111048 Ensembl | MGI Sequence Detail 777 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
InterPro IPR001810 F-box domain, cyclin-like
Protein Ontology PR:000005127 cyclin-F
References
(Earliest) J:22795 Obermayr F, et al., Mouse cyclin F maps to a conserved linkage group on mouse chromosome 17. Mamm Genome. 1995 Feb;6(2):149-50
(Latest) J:191676 Manceau V, et al., The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
All references(37)
Other
accession IDs
MGD-MRK-19400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory