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Ccnf
Gene Detail
 Symbol
Name
ID
Ccnf
cyclin F
MGI:102551
Synonyms CycF, Fbxo1
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:24223232-24251409 bp, - strand
From NCBI annotation of GRCm38

  28178 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1335  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ccnf

Human
homologs
Human Homolog CCNF, cyclin F
NCBI Gene ID 899
neXtProt AC  NX_P41002
Human Synonyms  FBX1, FBXO1
Human Chr (Location)  16p13.3; chr16:2429394-2458858 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(29) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality between E9.5 and E10.5 due to defects in yolk sac and chorioallantoic placenta maturation. Embryos show incomplete turning, underdeveloped posterior structures, neural tube closure and brain defects. MEFs have cell cycle defects.
 
Interactions
Ccnf interacts with 131 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell cycle, cell division, ...
Component centriole, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (58)    Tissues (5)    Images (22)
Theiler Stages: 21, 23
Assay TypeResults
RNA in situ 56
Western blot 2
cDNA source data(110)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) Genomic(1) cDNA(111)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000072082 (Evidence)
Entrez Gene12449 (Evidence)
UniGene77695
DFCITC1574117, TC1595326
DoTSDT.101403705, DT.101403707, DT.101741277, DT.531985, DT.91281256, DT.94262689, DT.97374823, DT.99861898
NIA Mouse Gene IndexU037522
Consensus CDS ProjectCCDS37484.1
International Mouse Knockout Project StatusCcnf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12449 NCBI Gene Model | MGI Sequence Detail 28178 C57BL/6J ±  kb
transcript NM_007634 RefSeq | MGI Sequence Detail 3099 C57BL/6 
polypeptide P51944 UniProt | EBI | MGI Sequence Detail 777 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
InterPro IPR001810 F-box domain, cyclin-like
Protein Ontology PR:000005127 cyclin-F
Graphical View of Protein Domain Structure
References (Earliest) J:22795 Obermayr F, et al., Mouse cyclin F maps to a conserved linkage group on mouse chromosome 17. Mamm Genome. 1995 Feb;6(2):149-50
(Latest) J:191676 Manceau V, et al., The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
All references(39)
Other
accession IDs
MGD-MRK-19400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory