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Pou4f1 Gene Detail
Summary
  • Symbol
    Pou4f1
  • Name
    POU domain, class 4, transcription factor 1
  • Synonyms
    Brn3, Brn-3, Brn-3.0, Brn3a, E130119J07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:102525
    NCBI Gene: 18996
  • Gene Overview
    MyGene.info: POU4F1
Location & Maps
more
  • Sequence Map
    Chr14:104461676-104467999 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6324 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 54.21 cM, cytoband E1-E3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    POU4F1, POU class 4 homeobox 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    POU4F1, POU class 4 homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    brn-3A, BRN3A, Oct-T1, RDC-1
  • Links
    NCBI Gene ID: 5457
    neXtProt AC: NX_Q01851

  • Chr Location
    13q31.1; chr13:78599092-78603560 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 8 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    6 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Pou4f1
Mice homozygous for disruptions in this gene die within the first day after birth and display various abnormalities in the brain and cranial nerves.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032816 VEGA Gene Model | MGI Sequence Detail 6324 C57BL/6J ±  kb
transcript OTTMUST00000081737 VEGA | MGI Sequence Detail 4445 Not Applicable  
polypeptide OTTMUSP00000043766 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    Genomic 9
    cDNA 16
    Primer pair 5
    Other 7

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1625, MGD-MRK-1629, MGD-MRK-1630, MGD-MRK-19369, MGI:1925256
References
more
  • Summaries
    All 291
    Developmental Gene Expression 227
    Gene Ontology 20
    Phenotypes 50
  • Earliest
    J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
  • Latest
    J:233763 Karpinski BA, et al., A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. Dev Biol. 2016 Jul 15;415(2):228-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory