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Cacnb1
Gene Detail
Symbol

Name
ID
Cacnb1
calcium channel, voltage-dependent, beta 1 subunit
MGI:102522
Synonyms
Cchb1, Cchlb1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:98001508-98023034 bp, - strand
From VEGA annotation of GRCm38

  21527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20186  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Cacnb1

Human
homologs
Human Homolog CACNB1, calcium channel, voltage-dependent, beta 1 subunit
NCBI Gene ID 782
neXtProt AC  NX_Q02641
Human Synonyms  CAB1, CACNLB1, CCHLB1
Human Chr (Location)  17q21-q22; chr17:39173456-39197703 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in perinatal lethality. Mutant animals have reduced muscle mass, thin limbs, a curved spine, and flexed necks and extremeties.
 
Phenotype Images(1)
Interactions
Cacnb1 interacts with 256 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component cell, intracellular, ...
Function calcium channel activity, high voltage-gated calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (159)    Tissues (40)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
RT-PCR 14
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000002912 (Evidence)
Ensembl Gene ModelENSMUSG00000020882 (Evidence)
Entrez Gene12295 (Evidence)
DFCITC1593619, TC1584319, TC1607224, TC1630903
DoTSDT.101371944, DT.101259077, DT.40181792, DT.101371945
NIA Mouse Gene IndexU033356
Consensus CDS ProjectCCDS25335.1, CCDS25336.1, CCDS48898.1, CCDS48899.1
International Mouse Knockout Project StatusCacnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002912 VEGA Gene Model | MGI Sequence Detail 21527 C57BL/6J ±  kb
transcript OTTMUST00000005964 VEGA | MGI Sequence Detail 3396 Not Applicable 
polypeptide OTTMUSP00000002817 VEGA | MGI Sequence Detail 597 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(20) UniProt(13)
Polymorphisms
RFLP(2) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR005443 Voltage-dependent calcium channel, L-type, beta-1 subunit
InterPro IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
Protein Ontology PR:000004946 voltage-dependent L-type calcium channel subunit beta-1
References
(Earliest) J:28890 Ruth P, et al., Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle. Science. 1989 Sep 8;245(4922):1115-8
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(55)
Other
accession IDs
MGD-MRK-1802, MGD-MRK-19366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory