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Adam3 Gene Detail
Summary
  • Symbol
    Adam3
  • Name
    a disintegrin and metallopeptidase domain 3 (cyritestin)
  • Synonyms
    ADAM3, Cyrn1, Taz83, Taz83, tMDC
  • Feature Type
    protein coding gene
  • IDs
    MGI:102518
    NCBI Gene: 11497
Location & Maps
more
  • Sequence Map
    Chr8:24677225-24725852 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48628 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADAM3A, ADAM metallopeptidase domain 3A (pseudogene)
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ADAM3A, ADAM metallopeptidase domain 3A (pseudogene)
    Orthology source: HGNC
  • Synonyms
    ADAM3, CYRN1, tMDCI
  • Links
    NCBI Gene ID: 1587

  • Chr Location
    8p11.23; chr8:39451045-39522989 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are male infertile, due to the inability of the sperm to bind to the zona pellucida. If the zona pellucida is removed sperm-egg membrane fusion happens as expected.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035967 VEGA Gene Model | MGI Sequence Detail 48628 C57BL/6J ±  kb
transcript OTTMUST00000092283 VEGA | MGI Sequence Detail 2736 Not Applicable  
polypeptide OTTMUSP00000050961 VEGA | MGI Sequence Detail 822 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    139 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19356
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:18471 Lemaire L, et al., Chromosomal assignment of three novel mouse genes expressed in testicular cells. Genomics. 1994 May 15;21(2):409-14
  • Latest
    J:210341 Fujihara Y, et al., GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Biol Reprod. 2014 Mar;90(3):60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory