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mt-Co1
Gene Detail
Symbol

Name
ID
mt-Co1
mitochondrially encoded cytochrome c oxidase I
MGI:102504
Synonyms
CCOI, COI, COX1, COX 1, CoxI, mt-Co1-201
Feature Type
protein coding gene
Genetic Map
Chromosome MT
Syntenic
Sequence Map
ChrMT:5328-6872 bp, + strand
From NCBI annotation of GRCm38

  1545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: mt-Co1

Human
homologs
Human Homolog COX1, cytochrome c oxidase subunit I
NCBI Gene ID 4512
neXtProt AC  NX_P00395
Human Synonyms  COI, MTCO1
Human Chr (Location)  MT
Disease Associations  (2) Diseases Associated with Human COX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Spontaneous(1)
 
Transmitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in this gene show growth retardation, reduced COX activity in cardiac cells, increased blood lactate levels, mitochondrial myopathy, heart inflammation and edema, abnormal blood vessel morphology, and severe cardiomyopathy.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process hydrogen ion transmembrane transport, oxidation-reduction process, ...
Component integral component of membrane, membrane, ...
Function cytochrome-c oxidase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (52)    Tissues (17)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Northern blot 22
Western blot 28
cDNA source data(37)
External Resources: Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(37) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000064351 (Evidence)
Entrez Gene17708
DFCITC1598614, TC1644897, TC1779104
EC1.9.3.1
International Mouse Knockout Project Statusmt-Co1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17708 NCBI Gene Model | MGI Sequence Detail 1545 C57BL/6J ±  kb
transcript AK138996 GenBank | EMBL | DDBJ | MGI Sequence Detail 1616 C57BL/6J 
polypeptide NP_904330 RefSeq | MGI Sequence Detail 514 C57BL/6J 

For the selected sequences
All sequences(89) RefSeq(1) UniProt(5)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000883 Cytochrome c oxidase, subunit I
InterPro IPR023615 Cytochrome c oxidase, subunit I, copper-binding site
InterPro IPR023616 Cytochrome c oxidase, subunit I domain
Protein Ontology PR:000010688 cytochrome c oxidase subunit 1
References
(Earliest) J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
(Latest) J:206222 Peralta S, et al., Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Hum Mol Genet. 2014 Mar 15;23(6):1399-412
All references(57)
Other
accession IDs
MGD-MRK-19341, MGI:2138416, MGI:2138422, MGI:2138439, MGI:2138442, MGI:2138443, MGI:2138447, MGI:2138450, MGI:2138454, MGI:2139180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory