mt-Co1
Gene Detail

Symbol Name ID

mt-Co1 mitochondrially encoded cytochrome c oxidase I MGI:102504

Synonyms

CCOI, COI, COX1, COX 1, CoxI, mt-Co1-201

Feature Type

protein coding gene

Genetic Map

Chromosome MT
Syntenic

Sequence Map

ChrMT:5328-6872 bp, + strand From NCBI annotation of GRCm38   1545 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: mt-Co1

Human homologs

Human Homolog		COX1, cytochrome c oxidase subunit I
NCBI Gene ID		4512
neXtProt AC		NX_P00395
Human Synonyms		COI, MTCO1
Human Chr (Location)		MT
Disease Associations		(2) Diseases Associated with Human COX1

Alleles and phenotypes

All alleles(2) : Gene trapped(1) Spontaneous(1)
 

Transmitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in this gene show growth retardation, reduced COX activity in cardiac cells, increased blood lactate levels, mitochondrial myopathy, heart inflammation and edema, abnormal blood vessel morphology, and severe cardiomyopathy.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	electron transport chain, ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	cytochrome-c oxidase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (52)    Tissues (15)    Images (5)
Theiler Stages: 9, 19, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
Northern blot	22
Western blot	28

cDNA source data(37)
External Resources: ArrayExpress

Molecular reagents

All nucleic(39) cDNA(37) Other(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000064351 (Evidence)
Entrez Gene	17708
DFCI	TC1598614, TC1644897, TC1779104
EC	1.9.3.1
International Mouse Knockout Project Status	mt-Co1

Sequences

Length	Strain/Species
genomic	17708	NCBI Gene Model | MGI Sequence Detail	1545	C57BL/6J
transcript	AK138996	GenBank | EMBL | DDBJ | MGI Sequence Detail	1616	C57BL/6J
polypeptide	NP_904330	RefSeq | MGI Sequence Detail	514	C57BL/6J

All sequences(89) RefSeq(1) UniProt(5)

Protein-related information

Resource	ID	Description
InterPro	IPR000883	Cytochrome c oxidase, subunit I
InterPro	IPR023615	Cytochrome c oxidase, subunit I, copper-binding site
InterPro	IPR023616	Cytochrome c oxidase, subunit I domain
Protein Ontology	PR:000010688	cytochrome c oxidase subunit 1
Protein Ontology	PR:000025364	cytochrome c oxidase subunit 1 (mouse)

References

(Earliest) J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
(Latest) J:185585 Hashizume O, et al., Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10528-33
All references(56)

Other accession IDs

MGD-MRK-19341, MGI:2138416, MGI:2138422, MGI:2138439, MGI:2138442, MGI:2138443, MGI:2138447, MGI:2138450, MGI:2138454, MGI:2139180