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mt-Co1 Gene Detail
Summary
  • Symbol
    mt-Co1
  • Name
    mitochondrially encoded cytochrome c oxidase I
  • Synonyms
    CCOI, COI, COX1, COX 1, CoxI, mt-Co1-201
  • Feature Type
    protein coding gene
  • IDs
    MGI:102504
    NCBI Gene: 17708
  • Gene Overview
    MyGene.info: COX1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrMT:5328-6872 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome MT, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102504
protein coding gene ChrMT:5328-6872 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0025337
protein coding gene Chr2:20169723-20174285 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0025124
protein coding gene Chr2:20078681-20080477 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029551
protein coding gene Chr6:6854470-6856618 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0025235
protein coding gene Chr2:19379897-19382379 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COX1, cytochrome c oxidase subunit I
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COX1, cytochrome c oxidase subunit I
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COI, MTCO1
  • Links
    NCBI Gene ID: 4512
    neXtProt AC: NX_P00395
    UniProt: P00395

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    1 with human COX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Transmitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in this gene show growth retardation, reduced COX activity in cardiac cells, increased blood lactate levels, mitochondrial myopathy, heart inflammation and edema, abnormal bloodvessel morphology, and severe cardiomyopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17708 NCBI Gene Model | MGI Sequence Detail 1545 C57BL/6J ±  kb
    transcript AK138996 GenBank | EMBL | DDBJ | MGI Sequence Detail 1616 C57BL/6J  
    polypeptide P00397 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 37
      Other 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-19341, MGI:2138416, MGI:2138422, MGI:2138439, MGI:2138442, MGI:2138443, MGI:2138447, MGI:2138450, MGI:2138454, MGI:2139180
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 24
      Gene Ontology 16
      Phenotypes 6
    • Earliest
      J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
    • Latest
      J:263836 Srivillibhuthur M, et al., TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol. 2018 Jul 15;439(2):92-101

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory