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mt-Co1
Gene Detail
Symbol

Name
ID
mt-Co1
mitochondrially encoded cytochrome c oxidase I
MGI:102504
Synonyms
CCOI, COI, COX1, COX 1, CoxI, mt-Co1-201
Feature Type
protein coding gene
Genetic Map
Chromosome MT
Syntenic
Sequence Map
ChrMT:5328-6872 bp, + strand
From Ensembl annotation of GRCm38

  1545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COX1
Gene Tree: mt-Co1

Human
homologs
COX1, cytochrome c oxidase subunit I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4512
neXtProt AC: NX_P00395

Human Synonyms: COI, MTCO1

Human Chr (Location): MT

Disease Associations: (2) Diseases Associated with Human COX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Spontaneous(1)
 
Transmitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in this gene show growth retardation, reduced COX activity in cardiac cells, increased blood lactate levels, mitochondrial myopathy, heart inflammation and edema, abnormal blood vessel morphology, and severe cardiomyopathy.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process aerobic respiration, hydrogen ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function cytochrome-c oxidase activity, electron carrier activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (52)    Tissues (17)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Northern blot 22
Western blot 28
cDNA source data(37)
Other mouse links: Expression Atlas
Other vertebrate links: Xenbase cox1    NEW 
Molecular
reagents
All nucleic(39) cDNA(37) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000064351 (Evidence)
Entrez Gene 17708
DFCI TC1598614, TC1779104, TC1644897
EC 1.9.3.1
International Mouse Phenotyping Consortium Status mt-Co1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064351 Ensembl Gene Model | MGI Sequence Detail 1545 C57BL/6J ±  kb
transcript ENSMUST00000082402 Ensembl | MGI Sequence Detail 1545 Not Applicable 
polypeptide ENSMUSP00000080993 Ensembl | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(1) UniProt(6)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000883 Cytochrome c oxidase, subunit I
InterPro IPR023615 Cytochrome c oxidase, subunit I, copper-binding site
InterPro IPR023616 Cytochrome c oxidase, subunit I domain
Protein Ontology PR:000010688 cytochrome c oxidase subunit 1
References
(Earliest) J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
(Latest) J:213453 Donti TR, et al., Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Dis Model Mech. 2014 Feb;7(2):271-80
All references(57)
Other
accession IDs
MGD-MRK-19341, MGI:2138416, MGI:2138422, MGI:2138439, MGI:2138442, MGI:2138443, MGI:2138447, MGI:2138450, MGI:2138454, MGI:2139180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory