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mt-Co2 Gene Detail
Summary
  • Symbol
    mt-Co2
  • Name
    mitochondrially encoded cytochrome c oxidase II
  • Synonyms
    COXII
  • Feature Type
    protein coding gene
  • IDs
    MGI:102503
    NCBI Gene: 17709
Location & Maps
more
  • Genetic Map
    Chromosome MT, Syntenic
Homology
more
  • Human Ortholog
    COX2, cytochrome c oxidase subunit II
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COX2, cytochrome c oxidase subunit II
    Orthology source: HomoloGene
  • Synonyms
    COII, MTCO2
  • Links
    NCBI Gene ID: 4513
    neXtProt AC: NX_P00403

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    1 with human COX2 associations

Human Disease Mouse Models
       Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes; MELAS   OMIM: 540000
Click on a disease name to see all genes associated with that disease.

Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064354 Ensembl Gene Model | MGI Sequence Detail 684 C57BL/6J ±  kb
transcript ENSMUST00000082405 Ensembl | MGI Sequence Detail 684 Not Applicable  
polypeptide ENSMUSP00000080994 Ensembl | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000025365 cytochrome c oxidase subunit 2
  • InterPro Domains
    IPR001505 Copper centre Cu(A)
    IPR008972 Cupredoxin
    IPR014222 Cytochrome c oxidase, subunit II
    IPR002429 Cytochrome c oxidase subunit II C-terminal
    IPR011759 Cytochrome C oxidase subunit II, transmembrane domain
Molecular
Reagents
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  • All nucleic 62
    cDNA 10
    Other 52

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-19340, MGI:2138430, MGI:2138457
References
more
  • Summaries
    All 29
    Developmental Gene Expression 5
    Gene Ontology 5
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:190206 Baris OR, et al., The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells. 2011 Sep;29(9):1459-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory