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mt-Co2
Gene Detail
 Symbol
Name
ID
mt-Co2
mitochondrially encoded cytochrome c oxidase II
MGI:102503
Synonyms COXII
Feature Type protein coding gene
Genetic Map
Chromosome MT
Syntenic
Sequence Map
ChrMT:7013-7696 bp, + strand
From NCBI annotation of GRCm38

  684 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:5017  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Cytochrome c oxidase, subunit 2, mitochondrial type
Gene Tree: mt-Co2

Human
homologs
Human Homolog COX2, cytochrome c oxidase subunit II
NCBI Gene ID 4513
neXtProt AC  NX_P00403
Human Synonyms  COII, MTCO2
Human Chr (Location)  MT
Disease Associations  (1) Diseases Associated with Human COX2
Interactions
mt-Co2 interacts with 3 markers (Mir101a, Mir199a-1, Mir199a-2)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process electron transport chain, oxidation-reduction process, ...
Component integral component of membrane, membrane, ...
Function copper ion binding, cytochrome-c oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 9
Assay TypeResults
Immunohistochemistry 2
cDNA source data(10)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(10) Other(52)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000064354 (Evidence)
Entrez Gene17709
DFCITC1579842
International Mouse Knockout Project Statusmt-Co2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17709 NCBI Gene Model | MGI Sequence Detail 684 C57BL/6J ±  kb
transcript AF378830 GenBank | EMBL | DDBJ | MGI Sequence Detail 725 Not Specified 
polypeptide P00405 UniProt | EBI | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(1) UniProt(2)
Protein-related
information
ResourceIDDescription
InterPro IPR001505 Copper centre Cu(A)
InterPro IPR008972 Cupredoxin
InterPro IPR014222 Cytochrome c oxidase, subunit II
InterPro IPR002429 Cytochrome c oxidase subunit II C-terminal
InterPro IPR011759 Cytochrome C oxidase subunit II, transmembrane domain
Protein Ontology PR:000025365 cytochrome c oxidase subunit 2
Graphical View of Protein Domain Structure
References (Earliest) J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
(Latest) J:190206 Baris OR, et al., The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells. 2011 Sep;29(9):1459-68
All references(34)
Other
accession IDs
MGD-MRK-19340, MGI:2138430, MGI:2138457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory