mt-Co2
Gene Detail

Symbol Name ID

mt-Co2 mitochondrially encoded cytochrome c oxidase II MGI:102503

Synonyms

COXII

Feature Type

protein coding gene

Genetic Map

Chromosome MT
Syntenic

Sequence Map

ChrMT:7013-7696 bp, + strand From NCBI annotation of GRCm38   684 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5017  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Cytochrome c oxidase, subunit 2, mitochondrial type
Gene Tree: mt-Co2

Human homologs

Human Homolog		COX2, cytochrome c oxidase subunit II
NCBI Gene ID		4513
neXtProt AC		NX_P00403
Human Synonyms		COII, MTCO2
Human Chr (Location)		MT
Disease Associations		(1) Diseases Associated with Human COX2

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	electron transport chain, oxidation-reduction process, ...
Component	integral to membrane, membrane, ...
Function	copper ion binding, cytochrome-c oxidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 9

Assay Type	Results
Immunohistochemistry	2

cDNA source data(10)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(62) cDNA(10) Other(52)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000064354 (Evidence)
Entrez Gene	17709
DFCI	TC1579842
International Mouse Knockout Project Status	mt-Co2

Sequences

Length	Strain/Species
genomic	17709	NCBI Gene Model | MGI Sequence Detail	684	C57BL/6J
transcript	AF378830	GenBank | EMBL | DDBJ | MGI Sequence Detail	725	Not Specified
polypeptide	P00405	UniProt | EBI | MGI Sequence Detail	227	Not Applicable

All sequences(57) RefSeq(1) UniProt(2)

Protein-related information

Resource	ID	Description
InterPro	IPR001505	Copper centre Cu(A)
InterPro	IPR008972	Cupredoxin
InterPro	IPR014222	Cytochrome c oxidase, subunit II
InterPro	IPR002429	Cytochrome c oxidase subunit II C-terminal
InterPro	IPR015964	Cytochrome C oxidase subunit II-like, transmembrane domain
InterPro	IPR011759	Cytochrome C oxidase subunit II, transmembrane domain
Protein Ontology	PR:000025365	cytochrome c oxidase subunit 2
Protein Ontology	PR:000025366	cytochrome c oxidase subunit 2 (mouse)

Graphical View of Protein Domain Structure

References

(Earliest) J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
(Latest) J:190206 Baris OR, et al., The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells. 2011 Sep;29(9):1459-68
All references(34)

Other accession IDs

MGD-MRK-19340, MGI:2138430, MGI:2138457