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mt-Co3 Gene Detail
Summary
  • Symbol
    mt-Co3
  • Name
    mitochondrially encoded cytochrome c oxidase III
  • Synonyms
    COIII, COX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:102502
    NCBI Gene: 17710
  • Gene Overview
    MyGene.info: COX3
Location & Maps
more
  • Genetic Map
    Chromosome MT, Syntenic
Homology
more
  • Human Ortholog
    COX3, cytochrome c oxidase III
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COX3, cytochrome c oxidase III
    Orthology source: HomoloGene
  • Synonyms
    COIII, MTCO3
  • Links
    NCBI Gene ID: 4514
    neXtProt AC: NX_P00414

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    2 with human COX3 associations

Human Disease Mouse Models
       Leber Optic Atrophy   OMIM: 535000
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes; MELAS   OMIM: 540000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    1
  • Spontaneous
    1
  • Genomic Mutations
    1 involving mt-Co3
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064358 Ensembl Gene Model | MGI Sequence Detail 784 C57BL/6J ±  kb
transcript ENSMUST00000082409 Ensembl | MGI Sequence Detail 784 Not Applicable  
polypeptide ENSMUSP00000080997 Ensembl | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010689 cytochrome c oxidase subunit 3
  • InterPro Domains
    IPR024791 Cytochrome c oxidase subunit III
    IPR013833 Cytochrome c oxidase, subunit III, 4-helical bundle
    IPR000298 Cytochrome c oxidase subunit III domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1
Other
Accession IDs
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MGD-MRK-19339, MGI:2138394, MGI:2138420, MGI:2138462, MGI:2138508
References
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  • Summaries
    All 29
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:143901 Yu X, et al., Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains. Genome Res. 2009 Jan;19(1):159-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory