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mt-Co3 Gene Detail
Summary
  • Symbol
    mt-Co3
  • Name
    mitochondrially encoded cytochrome c oxidase III
  • Synonyms
    COIII, COX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:102502
    NCBI Gene: 17710
  • Gene Overview
    MyGene.info: COX3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrMT:8607-9390 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome MT, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102502
protein coding gene ChrMT:8607-9390 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COX3, cytochrome c oxidase III
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COX3, cytochrome c oxidase III
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COIII, MTCO3
  • Links
    NCBI Gene ID: 4514
    neXtProt AC: NX_P00414
    UniProt: P00414

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    2 with human COX3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic 17710 NCBI Gene Model | MGI Sequence Detail 784 C57BL/6J ±  kb
transcript BC012020 GenBank | EMBL | DDBJ | MGI Sequence Detail 1616 C57BL/6  
polypeptide P00416 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010689 cytochrome c oxidase subunit 3
  • InterPro Domains
    IPR024791 Cytochrome c oxidase subunit III
    IPR013833 Cytochrome c oxidase, subunit III, 4-helical bundle
    IPR033945 Cytochrome c oxidase subunit III domain
    IPR000298 Cytochrome c oxidase subunit III-like
    IPR035973 Cytochrome c oxidase subunit III-like superfamily
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1
Other
Accession IDs
less
MGD-MRK-19339, MGI:2138394, MGI:2138420, MGI:2138462, MGI:2138508
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:239883 Richman TR, et al., Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun. 2016 Jun 20;7:11884

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory