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Nfatc1
Gene Detail
Symbol

Name
ID
Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
MGI:102469
Synonyms
2210017P03Rik, NFAT2, NFATc, NF-ATc
Feature Type
protein coding gene
Genetic Map
Chromosome 18
53.66 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr18:80606205-80713071 bp, - strand
From NCBI annotation of GRCm38

  106867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32336  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFATC1
Gene Tree: Nfatc1

Human
homologs
NFATC1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4772
neXtProt AC: NX_O95644

Human Synonyms: NFAT2, NFATc, NF-ATC, NF-ATc1.2

Human Chr (Location): 18q23; chr18:79395772-79529323 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in lethality throughout fetal growth and development due to cardiac failure. Mutants exhibit blood circulation, cardiac valve and ventricular septal abnormalities, edema, abdominal hemorrhage, and semilunar valveregurgitation.
 
Interactions
Nfatc1 interacts with 276 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process aortic valve morphogenesis, B-1a B cell differentiation, ...
Component cytoplasm, intracellular, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (118)    Tissues (103)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 96
RT-PCR 14
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NFATC1 ; Xenbase nfatc1 ; ZFIN nfatc1    NEW 
Molecular
reagents
All nucleic(61) Genomic(2) cDNA(54) Primer pair(5)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000033016 (Evidence)
Entrez Gene 18018 (Evidence)
UniGene 329560
DFCI TC1580228, TC1582074, TC1660231
DoTS DT.94179471, DT.489408, DT.87049914, DT.101373650, DT.101239880
NIA Mouse Gene Index U038611
Consensus CDS Project CCDS29369.1, CCDS37873.1, CCDS50335.1, CCDS50336.1
International Mouse Phenotyping Consortium Status Nfatc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18018 NCBI Gene Model | MGI Sequence Detail 106867 C57BL/6J ±  kb
transcript NM_001164110 RefSeq | MGI Sequence Detail 4896 C57BL/6 
polypeptide O88942 UniProt | EBI | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(12) UniProt(9)
Polymorphisms
SNPs within 2kb(881 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015647 Nuclear factor of activated T-cells 1
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000003113 nuclear factor of activated T-cells, cytoplasmic 1
Graphical View of Protein Domain Structure
References
(Earliest) J:22229 Li X, et al., Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995;68(3-4):185-91
(Latest) J:219810 Qu X, et al., Tie1 is required for lymphatic valve and collecting vessel development. Dev Biol. 2015 Mar 1;399(1):117-28
All references(193)
Other
accession IDs
MGD-MRK-19306, MGI:1919614, MGI:2147226, MGI:2147334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory