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Nfatc1
Gene Detail
 Symbol
Name
ID
Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
MGI:102469
Synonyms 2210017P03Rik, NFAT2, NFATc, NF-ATc
Feature Type protein coding gene
Genetic Map
Chromosome 18
53.66 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr18:80606205-80713071 bp, - strand
From NCBI annotation of GRCm38

  106867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32336  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nfatc1

Human
homologs
Human Homolog NFATC1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NCBI Gene ID 4772
neXtProt AC  NX_O95644
Human Synonyms  NFAT2, NFATc, NF-ATC
Human Chr (Location)  18q23; chr18:79395772-79529323 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality throughout fetal growth and development due to cardiac failure. Mutants exhibit blood circulation, cardiac valve and ventricular septal abnormalities, edema, abdominal hemorrhage, and semilunar valveregurgitation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process calcium ion transport, epithelial to mesenchymal transition, ...
Component cytoplasm, nuclear chromatin, ...
Function DNA binding, mitogen-activated protein kinase p38 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (63 records)
Data Summary: Results (123)    Tissues (105)    Images (22)
Theiler Stages: 1, 2, 3, 4, 5, 15, 17, 19, 21, 23, 24, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 96
RT-PCR 19
cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) Genomic(2) cDNA(54) Primer pair(4)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000033016 (Evidence)
Entrez Gene18018 (Evidence)
UniGene329560
DFCITC1580228, TC1582074, TC1660231
DoTSDT.101239880, DT.101373650, DT.489408, DT.87049914, DT.94179471
NIA Mouse Gene IndexU038611
Consensus CDS ProjectCCDS29369.1, CCDS37873.1, CCDS50335.1, CCDS50336.1
International Mouse Knockout Project StatusNfatc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18018 NCBI Gene Model | MGI Sequence Detail 106867 C57BL/6J ±  kb
transcript NM_001164110 RefSeq | MGI Sequence Detail 4896 C57BL/6 
polypeptide O88942 UniProt | EBI | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(12) UniProt(9)
Polymorphisms SNPs within 2kb(881 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015647 Nuclear factor of activated T-cells 1
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000003113 nuclear factor of activated T-cells, cytoplasmic 1
Graphical View of Protein Domain Structure
References (Earliest) J:22229 Li X, et al., Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995;68(3-4):185-91
(Latest) J:205486 Kurabayashi N, et al., Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 2013 Dec 15;27(24):2708-21
All references(173)
Other
accession IDs
MGD-MRK-19306, MGI:1919614, MGI:2147226, MGI:2147334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory