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Nfatc1 Gene Detail
Summary
  • Symbol
    Nfatc1
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
  • Synonyms
    2210017P03Rik, NFAT2, NFATc, NF-ATc
  • Feature Type
    protein coding gene
  • IDs
    MGI:102469
    NCBI Gene: 18018
  • Gene Overview
    MyGene.info: NFATC1
Location & Maps
more
  • Sequence Map
    Chr18:80606205-80713071 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106867 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 53.66 cM, cytoband E4
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    NFATC1, nuclear factor of activated T-cells 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFATC1, nuclear factor of activated T-cells 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NFAT2, NFATc, NF-ATC, NF-ATc1.2
  • Links
    NCBI Gene ID: 4772
    neXtProt AC: NX_O95644

  • Chr Location
    18q23; chr18:79395772-79529323 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 5 alleles in 7 genetic backgrounds
    42 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Targeted
    11
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Nfatc1
  • Incidental Mutations
Homozygous mutation of this gene results in lethality throughout fetal growth and development due to cardiac failure. Mutants exhibit blood circulation, cardiac valve and ventricular septal abnormalities, edema, abdominal hemorrhage, and semilunar valveregurgitation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18018 NCBI Gene Model | MGI Sequence Detail 106867 C57BL/6J ±  kb
transcript NM_001164110 RefSeq | MGI Sequence Detail 4896 C57BL/6  
polypeptide O88942 UniProt | EBI | MGI Sequence Detail 717 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    869 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000003113 nuclear factor of activated T-cells, cytoplasmic 1
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
    IPR002909 IPT domain
    IPR015647 Nuclear factor of activated T-cells 1
    IPR008366 Nuclear factor of activated T cells (NFAT)
    IPR008967 p53-like transcription factor, DNA-binding
    IPR032397 Rel homology dimerisation domain
    IPR011539 Rel homology domain (RHD), DNA-binding domain
Molecular
Reagents
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  • All nucleic 61
    Genomic 2
    cDNA 54
    Primer pair 5

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-19306, MGI:1919614, MGI:2147226, MGI:2147334
References
more
  • Summaries
    All 204
    Developmental Gene Expression 77
    Gene Ontology 38
    Phenotypes 59
  • Earliest
    J:22229 Li X, et al., Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995;68(3-4):185-91
  • Latest
    J:231966 Zhang H, et al., Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet. 2016 May;48(5):537-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory