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Ptpn14 Gene Detail
Summary
  • Symbol
    Ptpn14
  • Name
    protein tyrosine phosphatase, non-receptor type 14
  • Synonyms
    C130080N23Rik, OTTMUSG00000022087, PTP36
  • Feature Type
    protein coding gene
  • IDs
    MGI:102467
    NCBI Gene: 19250
  • Gene Overview
    MyGene.info: PTPN14
Location & Maps
more
  • Sequence Map
    Chr1:189728268-189876695 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      148428 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PTPN14, protein tyrosine phosphatase, non-receptor type 14
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PTPN14, protein tyrosine phosphatase, non-receptor type 14
    Orthology source: HomoloGene
  • Synonyms
    PEZ, PTP36
  • Links
    NCBI Gene ID: 5784
    neXtProt AC: NX_Q15678

  • Chr Location
    1q32.2; chr1:214336942-214551681 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PTPN14 associations

Human Disease Mouse Models
       Choanal Atresia and Lymphedema   OMIM: 613611
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit some postnatal growth retardation, decreased body weight, periorbital and limb edema, and lymphatic vessel hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022087 VEGA Gene Model | MGI Sequence Detail 148428 C57BL/6J ±  kb
transcript OTTMUST00000052440 VEGA | MGI Sequence Detail 10746 Not Applicable  
polypeptide OTTMUSP00000032123 VEGA | MGI Sequence Detail 1189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1273 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 72
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-19304, MGI:2442275, MGI:3705754
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:19880 Sawada M, et al., cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Biochem Biophys Res Commun. 1994 Aug 30;203(1):479-84
  • Latest
    J:209628 Brouillard P, et al., Genetics of lymphatic anomalies. J Clin Invest. 2014 Mar 3;124(3):898-904

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory