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Ptpn14
Gene Detail
 Symbol
Name
ID
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
MGI:102467
Synonyms C130080N23Rik, OTTMUSG00000022087, PTP36
Feature Type protein coding gene
Genetic Map
Chromosome 1
95.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:189786633-189876695 bp, + strand
From VEGA annotation of GRCm38

  90063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3941  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 14/21 types
Gene Tree: Ptpn14

Human
homologs
Human Homolog PTPN14, protein tyrosine phosphatase, non-receptor type 14
NCBI Gene ID 5784
neXtProt AC  NX_Q15678
Human Synonyms  PEZ, PTP36
Human Chr (Location)  1q32.2; chr1:214348267-214551681 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTPN14
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit some postnatal growth retardation, decreased body weight, periorbital and limb edema, and lymphatic vessel hyperplasia.
 
Interactions
Ptpn14 interacts with 479 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process dephosphorylation, lymphangiogenesis, ...
Component cytoplasm, cytoskeleton, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (35)    Tissues (7)    Images (17)
Theiler Stages: 23
Assay TypeResults
RNA in situ 35
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(72) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022087 (Evidence)
Ensembl Gene ModelENSMUSG00000026604 (Evidence)
Entrez Gene19250 (Evidence)
UniGene4498
DFCITC1581965, TC1585372, TC1589218, TC1627509, TC1637578
DoTSDT.101368379, DT.101735173, DT.40158413, DT.87056204, DT.91338229, DT.97347132
NIA Mouse Gene IndexU001269
EC3.1.3.48
Consensus CDS ProjectCCDS15609.1
International Mouse Knockout Project StatusPtpn14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022087 VEGA Gene Model | MGI Sequence Detail 90063 C57BL/6J ±  kb
transcript OTTMUST00000052440 VEGA | MGI Sequence Detail 10352 Not Applicable 
polypeptide OTTMUSP00000032123 VEGA | MGI Sequence Detail 1189 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(15) UniProt(9)
Polymorphisms SNPs within 2kb(1281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019750 Band 4.1 family
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR003595 Protein-tyrosine phosphatase, catalytic
InterPro IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013452 tyrosine-protein phosphatase non-receptor type 14
References (Earliest) J:19880 Sawada M, et al., cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Biochem Biophys Res Commun. 1994 Aug 30;203(1):479-84
(Latest) J:209628 Brouillard P, et al., Genetics of lymphatic anomalies. J Clin Invest. 2014 Mar 3;124(3):898-904
All references(42)
Other
accession IDs
MGD-MRK-19304, MGI:2442275, MGI:3705754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory