Ptpn14
Gene Detail

Symbol Name ID

Ptpn14 protein tyrosine phosphatase, non-receptor type 14 MGI:102467

Synonyms

C130080N23Rik, OTTMUSG00000022087, PTP36

Feature Type

protein coding gene

Genetic Map

Chromosome 1

95.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:189786633-189876695 bp, + strand From VEGA annotation of GRCm38   90063 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 14/21 types
Gene Tree: Ptpn14

Human homologs

Human Homolog		PTPN14, protein tyrosine phosphatase, non-receptor type 14
NCBI Gene ID		5784
neXtProt AC		NX_Q15678
Human Synonyms		PEZ, PTP36
Human Chr (Location)		1q32.2; chr1:214522039-214725024 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTPN14

Alleles and phenotypes

All alleles(21) : Targeted(3) Gene trapped(18)
 

Mice homozygous for a gene trap allele exhibit some postnatal growth retardation, decreased body weight, periorbital and limb edema, and lymphatic vessel hyperplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	dephosphorylation, lymphangiogenesis, ...
Component	cytoplasm, cytoskeleton, ...
Function	hydrolase activity, phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (35)    Tissues (7)    Images (17)
Theiler Stages: 23

Assay Type	Results
RNA in situ	35

cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(73) cDNA(72) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000022087 (Evidence)
Ensembl Gene Model	ENSMUSG00000026604 (Evidence)
Entrez Gene	19250 (Evidence)
UniGene	4498
DFCI	TC1581965, TC1585372, TC1589218, TC1627509, TC1637578
DoTS	DT.101368379, DT.101735173, DT.40158413, DT.87056204, DT.91338229, DT.97347132
NIA Mouse Gene Index	U001269
EC	3.1.3.48
Consensus CDS Project	CCDS15609.1
International Mouse Knockout Project Status	Ptpn14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022087	VEGA Gene Model | MGI Sequence Detail	90063	C57BL/6J
transcript	OTTMUST00000052440	VEGA | MGI Sequence Detail	10352	Not Applicable
polypeptide	OTTMUSP00000032123	VEGA | MGI Sequence Detail	1189	Not Applicable

All sequences(60) RefSeq(3) UniProt(11)

Polymorphisms

SNPs(719 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR019750	Band 4.1 family
InterPro	IPR014352	FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro	IPR019748	FERM central domain
InterPro	IPR019747	FERM conserved site
InterPro	IPR018980	FERM, C-terminal PH-like domain
InterPro	IPR000299	FERM domain
InterPro	IPR018979	FERM, N-terminal
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR003595	Protein-tyrosine phosphatase, catalytic
InterPro	IPR014392	Protein-tyrosine phosphatase, non-receptor type-14, -21
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013452	tyrosine-protein phosphatase non-receptor type 14

References

(Earliest) J:19880 Sawada M, et al., cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Biochem Biophys Res Commun. 1994 Aug 30;203(1):479-84
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)

Other accession IDs

MGD-MRK-19304, MGI:2442275, MGI:3705754