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Slc9a1
Gene Detail
Symbol

Name
ID
Slc9a1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
MGI:102462
Synonyms
antiporter, Apnh, Nhe1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
66.25 cM, cytoband D3-E
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr4:133369706-133423702 bp, + strand
From VEGA annotation of GRCm38

  53997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20660  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC9A1
Gene Tree: Slc9a1

Human
homologs
SLC9A1, solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6548
neXtProt AC: NX_P19634

Human Synonyms: APNH, LIKNS, NHE1, NHE-1, PPP1R143

Human Chr (Location): 1p36.1-p35; chr1:27098809-27155130 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC9A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Spontaneous(1) Targeted(4)
Genomic Mutations involving Slc9a1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Two-thirds of homozygous null mice die before weaning with reduced body weight, ataxia, a relatively mild stomach phenotype, and a postmortem appearance suggestive of death by a convulsive seizure. Homozygotes also display impaired fluid secretion and NaCl absorption in their parotid glands.
 
Phenotype Images(1)
Interactions
Slc9a1 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process cardiac muscle cell differentiation, cation transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function antiporter activity, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (211)    Tissues (124)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 113
Western blot 66
RT-PCR 28
cDNA source data(108)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc9a1    NEW 
Molecular
reagents
All nucleic(117) cDNA(111) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000011153 (Evidence)
Ensembl Gene Model ENSMUSG00000028854 (Evidence)
Entrez Gene 20544 (Evidence)
UniGene 4312
DFCI TC1589332, TC1576028, TC1589164
DoTS DT.101382490, DT.491463
NIA Mouse Gene Index U004916
Consensus CDS Project CCDS38903.1
International Mouse Phenotyping Consortium Status Slc9a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011153 VEGA Gene Model | MGI Sequence Detail 53997 C57BL/6J ±  kb
transcript OTTMUST00000026125 VEGA | MGI Sequence Detail 4676 Not Applicable 
polypeptide OTTMUSP00000011959 VEGA | MGI Sequence Detail 820 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(7)
Polymorphisms
All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs within 2kb(455 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR001970 Na+/H+ exchanger, isoform 1 (NHE1)
Protein Ontology PR:000015210 sodium/hydrogen exchanger 1
References
(Earliest) J:12498 Mattei MG, et al., Localization of the antiporter gene (APNH) and chromosomal segment homology between human 1p, mouse 4 and Chinese hamster 2q. Cytogenet Cell Genet. 1989;51:1041
(Latest) J:220149 Prasad V, et al., NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease. Biochem Biophys Res Commun. 2014 Jul 25;450(2):1027-31
All references(104)
Other
accession IDs
MGD-MRK-12876, MGD-MRK-1362, MGD-MRK-19299, MGI:1196422, MGI:2140598

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory