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Wnt11
Gene Detail
Symbol

Name
ID
Wnt11
wingless-type MMTV integration site family, member 11
MGI:101948
Feature Type
protein coding gene
Genetic Map
Chromosome 7
53.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr7:98835112-98855195 bp, + strand
From VEGA annotation of GRCm38

  20084 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20970  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt11

Human
homologs
Human Homolog WNT11, wingless-type MMTV integration site family, member 11
NCBI Gene ID 7481
neXtProt AC  NX_O96014
Human Synonyms  HWNT11
Human Chr (Location)  11q13.5; chr11:76186326-76210759 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in extensive embryonic lethality and mutants surviving to birth die within the first 2 days of life. The kidneys are small and exhibit delayed development.
 
Interactions
Wnt11 interacts with 198 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process artery morphogenesis, bone mineralization, ...
Component cytoplasm, extracellular region, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (147 records)
Data Summary: Results (713)    Tissues (515)    Images (142)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 621
RT-PCR 84
RNase protection 2
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(27) Primer pair(14) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036052 (Evidence)
Ensembl Gene ModelENSMUSG00000015957 (Evidence)
Entrez Gene22411 (Evidence)
UniGene22182
DFCITC1597606, TC1587635
DoTSDT.94230101, DT.40147241
NIA Mouse Gene IndexU008431
Consensus CDS ProjectCCDS21475.1
International Mouse Knockout Project StatusWnt11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036052 VEGA Gene Model | MGI Sequence Detail 20084 C57BL/6J ±  kb
transcript OTTMUST00000092561 VEGA | MGI Sequence Detail 3451 Not Applicable 
polypeptide OTTMUSP00000051187 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(12) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR026536 Wnt-11 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017438 protein Wnt-11
References
(Earliest) J:21464 Adamson MC, et al., Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics. 1994 Nov 1;24(1):9-13
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(196)
Other
accession IDs
MGD-MRK-18782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory