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Wnt11 Gene Detail
Summary
  • Symbol
    Wnt11
  • Name
    wingless-type MMTV integration site family, member 11
  • Feature Type
    protein coding gene
  • IDs
    MGI:101948
    NCBI Gene: 22411
  • Gene Overview
    MyGene.info: WNT11
Location & Maps
more
  • Sequence Map
    Chr7:98835112-98855195 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20084 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.90 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    WNT11, Wnt family member 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT11, Wnt family member 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HWNT11
  • Links
    NCBI Gene ID: 7481
    neXtProt AC: NX_O96014

  • Chr Location
    11q13.5; chr11:76186326-76214008 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Wnt11
  • Incidental Mutations
Homozygous mutation of this gene results in extensive embryonic lethality and mutants surviving to birth die within the first 2 days of life. The kidneys are small and exhibit delayed development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036052 VEGA Gene Model | MGI Sequence Detail 20084 C57BL/6J ±  kb
transcript OTTMUST00000092561 VEGA | MGI Sequence Detail 3451 Not Applicable  
polypeptide OTTMUSP00000051187 VEGA | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    177 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 48
    cDNA 27
    Primer pair 14
    Other 7

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-18782
References
more
  • Summaries
    All 210
    Developmental Gene Expression 163
    Gene Ontology 13
    Phenotypes 28
  • Earliest
    J:21464 Adamson MC, et al., Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics. 1994 Nov 1;24(1):9-13
  • Latest
    J:230715 Franco CA, et al., Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory