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Wnt11 Gene Detail
Summary
  • Symbol
    Wnt11
  • Name
    wingless-type MMTV integration site family, member 11
  • Feature Type
    protein coding gene
  • IDs
    MGI:101948
    NCBI Gene: 22411
  • Gene Overview
    MyGene.info: WNT11
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:98834916-98854747 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.90 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101948
protein coding gene Chr7:98834916-98855195 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032543
protein coding gene Chr7:101593201-101613210 (+)
A/J MGP_AJ_G0032517
protein coding gene Chr7:99078667-99098666 (+)
AKR/J MGP_AKRJ_G0032453
protein coding gene Chr7:101432996-101453343 (+)
BALB/cJ MGP_BALBcJ_G0032528
protein coding gene Chr7:98762486-98782498 (+)
C3H/HeJ MGP_C3HHeJ_G0032243
protein coding gene Chr7:101779496-101800685 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033026
protein coding gene Chr7:105514071-105535493 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030021
protein coding gene Chr7:101504814-101524576 (+)
CAST/EiJ MGP_CASTEiJ_G0031570
protein coding gene Chr7:93305817-93325926 (+)
CBA/J MGP_CBAJ_G0032210
protein coding gene Chr7:109102932-109128534 (+)
DBA/2J MGP_DBA2J_G0032362
protein coding gene Chr7:97405936-97426021 (+)
FVB/NJ MGP_FVBNJ_G0032319
protein coding gene Chr7:97207057-97227063 (+)
LP/J MGP_LPJ_G0032451
protein coding gene Chr7:102921121-102941205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032351
protein coding gene Chr7:110613805-110635120 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033048
protein coding gene Chr7:100695555-100715589 (+)
PWK/PhJ MGP_PWKPhJ_G0031288
protein coding gene Chr7:90491857-90512222 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031131
protein coding gene Chr7:87990249-88010246 (+)
WSB/EiJ MGP_WSBEiJ_G0031687
protein coding gene Chr7:101366935-101386987 (+)



Homology
more
  • Human Ortholog
    WNT11, Wnt family member 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT11, Wnt family member 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HWNT11
  • Links
    NCBI Gene ID: 7481
    neXtProt AC: NX_O96014
    UniProt: O96014

  • Chr Location
    11q13.5; chr11:76186326-76210842 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in extensive embryonic lethality and mutants surviving to birth die within the first 2 days of life. The kidneys are small and exhibit delayed development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22411 NCBI Gene Model | MGI Sequence Detail 19832 C57BL/6J ±  kb
    transcript NM_001285792 RefSeq | MGI Sequence Detail 3022 C57BL/6  
    polypeptide P48615 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 29
      Primer pair 15
      Other 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18782
    References
    more
    • Summaries
      All 258
      Developmental Gene Expression 191
      Gene Ontology 15
      Phenotypes 33
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:264120 Rowan CJ, et al., Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFbeta signaling. Development. 2018 Jul 9;145(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory