About   Help   FAQ
Car5a Gene Detail
Summary
  • Symbol
    Car5a
  • Name
    carbonic anhydrase 5a, mitochondrial
  • Synonyms
    Car5
  • Feature Type
    protein coding gene
  • IDs
    MGI:101946
    NCBI Gene: 12352
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121916135-121944912 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    530 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101946
protein coding gene Chr8:121916126-121944912 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034218
protein coding gene Chr8:125438344-125468634 (-)
A/J MGP_AJ_G0034198
protein coding gene Chr8:120232315-120263085 (-)
AKR/J MGP_AKRJ_G0034125
protein coding gene Chr8:123759489-123789802 (-)
BALB/cJ MGP_BALBcJ_G0034192
protein coding gene Chr8:120438259-120466971 (-)
C3H/HeJ MGP_C3HHeJ_G0033903
protein coding gene Chr8:124451355-124480441 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034712
protein coding gene Chr8:129619136-129648787 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031654
protein coding gene Chr8:113067355-113097451 (-)
CAST/EiJ MGP_CASTEiJ_G0033230
protein coding gene Chr8:124503879-124537111 (-)
CBA/J MGP_CBAJ_G0033876
protein coding gene Chr8:134399426-134431880 (-)
DBA/2J MGP_DBA2J_G0034032
protein coding gene Chr8:119430307-119459613 (-)
FVB/NJ MGP_FVBNJ_G0033975
protein coding gene Chr8:118540475-118570798 (-)
LP/J MGP_LPJ_G0034121
protein coding gene Chr8:125561055-125589652 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034022
protein coding gene Chr8:136599719-136632187 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034730
protein coding gene Chr8:123928271-123957127 (-)
PWK/PhJ MGP_PWKPhJ_G0032932
protein coding gene Chr8:119235615-119266507 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032772
protein coding gene Chr8:122638171-122668663 (-)
WSB/EiJ MGP_WSBEiJ_G0033346
protein coding gene Chr8:124679891-124715854 (-)



Homology
more
  • Human Ortholog
    CA5A, carbonic anhydrase 5A
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CA5A, carbonic anhydrase 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CA5, CA5AD, CAV, CAVA, GS1-21A4.1
  • Links
    NCBI Gene ID: 763
    neXtProt AC: NX_P35218
    UniProt: P35218

  • Chr Location
    16q24.2; chr16:87888019-87936575 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body size, hyperammonemia, and increased levels of urinary metabolites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12352 NCBI Gene Model | MGI Sequence Detail 28778 C57BL/6J ±  kb
    transcript NM_007608 RefSeq | MGI Sequence Detail 1248 C57BL/6  
    polypeptide P23589 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18780
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 5
    • Earliest
      J:22511 Amor-Gueret M, et al., Nucleotide and derived amino-acid sequence of a cDNA encoding a new mouse carbonic anhydrase. Nucleic Acids Res. 1990 Mar 25;18(6):1646
    • Latest
      J:196135 Shah GN, et al., Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7423-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory