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Arhgdib
Gene Detail
Symbol

Name
ID
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
MGI:101940
Synonyms
D4, Gdid4, Ly-GDI
Feature Type
protein coding gene
Genetic Map
Chromosome 6
66.72 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:136923523-136941899 bp, - strand
From VEGA annotation of GRCm38

  18377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARHGDIB
Protein SuperFamily: rho GDP dissociation inhibitor
Gene Tree: Arhgdib

Human
homologs
ARHGDIB, Rho GDP dissociation inhibitor (GDI) beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 397
neXtProt AC: NX_P52566

Human Synonyms: D4, GDIA2, GDID4, Ly-GDI, LYGDI, RAP1GN1, RhoGDI2

Human Chr (Location): 12p12.3; chr12:14942015-14961628 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
A homozygous null mutation results in mice that are viable and fertile. Immune responses are similar to controls in mice, but in vitro analysis demonstrated an increased B cell proliferative response upon lectin stimulation.
 
Interactions
Arhgdib interacts with 111 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process metabolic process, negative regulation of trophoblast cell migration
Component cytoplasm, cytosol, ...
Function GTPase activator activity, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (75)    Tissues (24)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
Northern blot 18
cDNA source data(77)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase arhgdib    NEW 
Molecular
reagents
All nucleic(79) Genomic(1) cDNA(78)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023287 (Evidence)
Ensembl Gene Model ENSMUSG00000030220 (Evidence)
Entrez Gene 11857 (Evidence)
UniGene 2241
DFCI TC1663217, TC1578001
DoTS DT.495376, DT.97407092, DT.94371637
NIA Mouse Gene Index U027980
Consensus CDS Project CCDS20661.1
International Mouse Phenotyping Consortium Status Arhgdib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023287 VEGA Gene Model | MGI Sequence Detail 18377 C57BL/6J ±  kb
transcript OTTMUST00000056391 VEGA | MGI Sequence Detail 1325 Not Applicable 
polypeptide OTTMUSP00000027098 VEGA | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(294 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR024792 Rho GDP-dissociation inhibitor domain
InterPro IPR000406 RHO protein GDP dissociation inhibitor
Protein Ontology PR:000004243 rho GDP-dissociation inhibitor 2
References
(Earliest) J:18526 Adra CN, et al., Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. Genes Chromosomes Cancer. 1993 Dec;8(4):253-61
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)
Other
accession IDs
MGD-MRK-18774

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory