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Hmgcs2 Gene Detail
Summary
  • Symbol
    Hmgcs2
  • Name
    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
  • Synonyms
    mHS
  • Feature Type
    protein coding gene
  • IDs
    MGI:101939
    NCBI Gene: 15360
  • Gene Overview
    MyGene.info: HMGCS2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:98280435-98310738 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.74 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101939
protein coding gene Chr3:98280431-98310738 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027650
protein coding gene Chr3:99281909-99311111 (+)
A/J MGP_AJ_G0027612
protein coding gene Chr3:96095665-96122098 (+)
AKR/J MGP_AKRJ_G0027579
protein coding gene Chr3:98395653-98424796 (+)
BALB/cJ MGP_BALBcJ_G0027622
protein coding gene Chr3:95892600-95918732 (+)
C3H/HeJ MGP_C3HHeJ_G0027354
protein coding gene Chr3:98660476-98686882 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028068
protein coding gene Chr3:102948857-102978687 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025410
protein coding gene Chr3:92333204-92357953 (+)
CAST/EiJ MGP_CASTEiJ_G0026809
protein coding gene Chr3:97968972-97996974 (+)
CBA/J MGP_CBAJ_G0027329
protein coding gene Chr3:106621124-106655430 (+)
DBA/2J MGP_DBA2J_G0027472
protein coding gene Chr3:95398992-95425133 (+)
FVB/NJ MGP_FVBNJ_G0027441
protein coding gene Chr3:93394310-93423545 (+)
LP/J MGP_LPJ_G0027577
protein coding gene Chr3:100544948-100571331 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027467
protein coding gene Chr3:112684599-112710479 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028122
protein coding gene Chr3:98014724-98040862 (+)
PWK/PhJ MGP_PWKPhJ_G0026534
protein coding gene Chr3:95298048-95324379 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026356
protein coding gene Chr3:96294762-96321066 (+)
WSB/EiJ MGP_WSBEiJ_G0026887
protein coding gene Chr3:98461552-98487768 (+)



Homology
more
  • Human Ortholog
    HMGCS2, 3-hydroxy-3-methylglutaryl-CoA synthase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HMGCS2, 3-hydroxy-3-methylglutaryl-CoA synthase 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3158
    neXtProt AC: NX_P54868
    UniProt: P54868

  • Chr Location
    1p12; chr1:119747996-119769125 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027875 Ensembl Gene Model | MGI Sequence Detail 30304 C57BL/6J ±  kb
transcript ENSMUST00000120541 Ensembl | MGI Sequence Detail 2524 Not Applicable  
polypeptide ENSMUSP00000113296 Ensembl | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008638 hydroxymethylglutaryl-CoA synthase, mitochondrial
  • EC
  • InterPro Domains
    IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
    IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
    IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
    IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
    IPR016039 Thiolase-like
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-18773
References
more
  • Summaries
    All 58
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 11
    Phenotypes 5
  • Earliest
    J:17114 Valera A, et al., Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis. J Biol Chem. 1994 Mar 4;269(9):6267-70
  • Latest
    J:249661 Schatton D, et al., CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017 Mar 06;216(3):675-693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory