Hmgcs2
Gene Detail

Symbol Name ID

Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 MGI:101939

Synonyms

mHS

Feature Type

protein coding gene

Genetic Map

Chromosome 3

42.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr3:98280435-98310738 bp, + strand From VEGA annotation of GRCm38   30304 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: 3-hydroxy-3-methylglutaryl CoA synthase
Gene Tree: Hmgcs2

Human homologs

Human Homolog		HMGCS2, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
NCBI Gene ID		3158
neXtProt AC		NX_P54868
Human Chr (Location)		1p13-p12; chr1:120290619-120311555 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HMGCS2

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cholesterol biosynthetic process, cholesterol metabolic process, ...
Component	mitochondrial inner membrane, mitochondrial matrix, ...
Function	catalytic activity, hydroxymethylglutaryl-CoA synthase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (580)    Tissues (241)    Images (49)
Theiler Stages: 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	580

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026370 (Evidence)
Ensembl Gene Model	ENSMUSG00000027875 (Evidence)
Entrez Gene	15360 (Evidence)
DFCI	TC1572016
DoTS	DT.55107670
NIA Mouse Gene Index	U021035
EC	2.3.3.10
Consensus CDS Project	CCDS17662.1
International Mouse Knockout Project Status	Hmgcs2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026370	VEGA Gene Model | MGI Sequence Detail	30304	C57BL/6J
transcript	OTTMUST00000065217	VEGA | MGI Sequence Detail	3290	Not Applicable
polypeptide	OTTMUSP00000032467	VEGA | MGI Sequence Detail	508	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(267 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010122	Hydroxymethylglutaryl-CoA synthase, eukaryotic
InterPro	IPR000590	Hydroxymethylglutaryl-coenzyme A synthase, active site
InterPro	IPR013746	Hydroxymethylglutaryl-coenzyme A synthase C-terminal
InterPro	IPR013528	Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
Protein Ontology	PR:000008638	hydroxymethylglutaryl-CoA synthase, mitochondrial

References

(Earliest) J:17114 Valera A, et al., Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis. J Biol Chem. 1994 Mar 4;269(9):6267-70
(Latest) J:193988 Grimsrud PA, et al., A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab. 2012 Nov 7;16(5):672-83
All references(47)

Other accession IDs

MGD-MRK-18773