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Pkib Gene Detail
Summary
  • Symbol
    Pkib
  • Name
    protein kinase inhibitor beta, cAMP dependent, testis specific
  • Synonyms
    PKIbeta, Prkacn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101937
    NCBI Gene: 18768
  • Gene Overview
    MyGene.info: PKIB
Location & Maps
more
  • Sequence Map
    Chr10:57631981-57741112 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      109132 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 29.22 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PKIB, protein kinase (cAMP-dependent, catalytic) inhibitor beta
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PKIB, protein kinase (cAMP-dependent, catalytic) inhibitor beta
    Orthology source: HomoloGene
  • Synonyms
    PRKACN2
  • Links
    NCBI Gene ID: 5570
    neXtProt AC: NX_Q9C010

  • Chr Location
    6q22.31; chr6:122471917-122726373 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Pkib
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit reduced protein kinase inhibitor activity in the testis but are phenotypically normal and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042041 VEGA Gene Model | MGI Sequence Detail 109132 C57BL/6J ±  kb
transcript OTTMUST00000110218 VEGA | MGI Sequence Detail 3311 Not Applicable  
polypeptide OTTMUSP00000061447 VEGA | MGI Sequence Detail 110 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    554 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000012780 cAMP-dependent protein kinase inhibitor beta
  • InterPro Domains
    IPR004171 cAMP-dependent protein kinase inhibitor
Molecular
Reagents
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  • All nucleic 31
    cDNA 29
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-18770, MGD-MRK-37287, MGI:108248
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:12694 Scarpetta MA, et al., Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse. J Biol Chem. 1993 May 25;268(15):10927-31
  • Latest
    J:224174 Blanchet E, et al., Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Cell Rep. 2015 Feb 24;10(7):1149-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory