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Pkib Gene Detail
Summary
  • Symbol
    Pkib
  • Name
    protein kinase inhibitor beta, cAMP dependent, testis specific
  • Synonyms
    PKIbeta, Prkacn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101937
    NCBI Gene: 18768
  • Gene Overview
    MyGene.info: PKIB
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:57631981-57741112 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 29.22 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    554 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101937
protein coding gene Chr10:57631981-57741112 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017240
protein coding gene Chr10:57007611-57123467 (+)
A/J MGP_AJ_G0017216
protein coding gene Chr10:55340756-55456886 (+)
AKR/J MGP_AKRJ_G0017176
protein coding gene Chr10:56503813-56615001 (+)
BALB/cJ MGP_BALBcJ_G0017178
protein coding gene Chr10:55456315-55566423 (+)
C3H/HeJ MGP_C3HHeJ_G0017000
protein coding gene Chr10:56729759-56841549 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017636
protein coding gene Chr10:58786178-58901700 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015329
protein coding gene Chr10:52201077-52294788 (+)
CAST/EiJ MGP_CASTEiJ_G0016573
protein coding gene Chr10:56674924-56789002 (+)
CBA/J MGP_CBAJ_G0016972
protein coding gene Chr10:61246915-61373305 (+)
DBA/2J MGP_DBA2J_G0017077
protein coding gene Chr10:54688498-54796492 (+)
FVB/NJ MGP_FVBNJ_G0017072
protein coding gene Chr10:53931186-54040462 (+)
LP/J MGP_LPJ_G0017152
protein coding gene Chr10:57095157-57219197 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017101
protein coding gene Chr10:63461725-63581888 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017673
protein coding gene Chr10:56316126-56429648 (+)
PWK/PhJ MGP_PWKPhJ_G0016354
protein coding gene Chr10:54476610-54583589 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016140
protein coding gene Chr10:55992305-56091714 (+)
WSB/EiJ MGP_WSBEiJ_G0016638
protein coding gene Chr10:56523368-56634785 (+)



Homology
more
  • Human Ortholog
    PKIB, cAMP-dependent protein kinase inhibitor beta
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PKIB, cAMP-dependent protein kinase inhibitor beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRKACN2
  • Links
    NCBI Gene ID: 5570
    neXtProt AC: NX_Q9C010
    UniProt: Q9C010

  • Chr Location
    6q22.31; chr6:122471917-122726373 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Pkib
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygotes for a targeted null mutation exhibit reduced protein kinase inhibitor activity in the testis but are phenotypically normal and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18768 NCBI Gene Model | MGI Sequence Detail 109132 C57BL/6J ±  kb
transcript NM_001039050 RefSeq | MGI Sequence Detail 5581 NOD  
polypeptide Q04758 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 30
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18770, MGD-MRK-37287, MGI:108248
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:224174 Blanchet E, et al., Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Cell Rep. 2015 Feb 24;10(7):1149-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory