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Pkib Gene Detail
Summary
  • Symbol
    Pkib
  • Name
    protein kinase inhibitor beta, cAMP dependent, testis specific
  • Synonyms
    PKIbeta, Prkacn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101937
    NCBI Gene: 18768
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:57508077-57617208 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.22 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2855 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101937
 protein coding gene Chr10:57508077-57617208 (+)
129S1/SvImJ ENSMUSG00200027441
 protein coding gene Chr10:54421465-54530597 (+)
A/J ENSMUSG00195027814
 protein coding gene Chr10:54675347-54784485 (+)
AKR/J ENSMUSG00220040494
 protein coding gene Chr10:54401306-54510440 (+)
BALB/cJ ENSMUSG00180021736
 protein coding gene Chr10:54804720-54913861 (+)
C3H/HeJ ENSMUSG00175025860
 protein coding gene Chr10:54629829-54738976 (+)
C57BL/6NJ ENSMUSG00215028348
 protein coding gene Chr10:54327732-54436866 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015329
 protein coding gene Chr10:52201077-52294788 (+)
CAST/EiJ ENSTCUG00005026450
 protein coding gene Chr10:54462094-54564671 (+)
CBA/J ENSMUSG00210035489
 protein coding gene Chr10:54442421-54551557 (+)
DBA/2J ENSMUSG00185039170
 protein coding gene Chr10:54605024-54714144 (+)
FVB/NJ ENSMUSG00205017370
 protein coding gene Chr10:54500053-54608973 (+)
JF1/MsJ ENSUMUG00000008976
 protein coding gene Chr10:54207993-54311076 (+)
LP/J ENSMUSG00230020378
 protein coding gene Chr10:56406134-56515266 (+)
NOD/ShiLtJ ENSMUSG00190031119
 protein coding gene Chr10:54786652-54895780 (+)
NZO/HlLtJ ENSMUSG00225022645
 protein coding gene Chr10:60692279-60801400 (+)
PWK/PhJ ENSLUMG00010022699
 protein coding gene Chr10:54413814-54516513 (+)
SPRET/EiJ ENSMSPG00010026202
 protein coding gene Chr10:56062906-56146674 (+)
WSB/EiJ ENSIUOG00005041273
 protein coding gene Chr10:54445863-54554977 (+)



Homology
more
  • Human Ortholog
    PKIB, cAMP-dependent protein kinase inhibitor beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKIB, cAMP-dependent protein kinase inhibitor beta
  • Synonyms
    PRKACN2
  • Links
    NCBI Gene ID: 5570
    UniProt: Q9C010

  • Chr Location
    6q22.31; chr6:122471917-122726375 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Homozygotes for a targeted null mutation exhibit reduced protein kinase inhibitor activity in the testis but are phenotypically normal and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    46
  • cDNA Data
    30
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18768 NCBI Gene Model | MGI Sequence Detail 109132 C57BL/6J ±  kb
transcript NM_001039050 RefSeq | MGI Sequence Detail 5581 NOD  
polypeptide Q04758 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000012780 cAMP-dependent protein kinase inhibitor beta
    (term hierarchy)
  • InterPro Domains
    IPR004171 cAMP-dependent protein kinase inhibitor
  • GlyGen
    Q04758 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 34
    cDNA 30
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-18770, MGD-MRK-37287, MGI:108248
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory