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Slc1a2
Gene Detail
Symbol

Name
ID
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
MGI:101931
Synonyms
1700091C19Rik, 2900019G14Rik, Eaat2, GLT1, GLT-1, MGLT1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:102658659-102790784 bp, + strand
From VEGA annotation of GRCm38

  132126 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC1A2
Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a2

Human
homologs
SLC1A2, solute carrier family 1 (glial high affinity glutamate transporter), member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6506
neXtProt AC: NX_P43004

Human Synonyms: EAAT2, GLT-1, HBGT

Human Chr (Location): 11p13-p12; chr11:35251205-35420063 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Slc1a2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display spontaneous seizures often leading to death as well as a succeptibility to neuronal degeneration.
 
Interactions
Slc1a2 interacts with 598 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (353)    Tissues (177)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 286
Western blot 6
RT-PCR 59
cDNA source data(22)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase slc1a2 ; ZFIN slc1a2a, slc1a2b    NEW 
Molecular
reagents
All nucleic(30) cDNA(24) Primer pair(4) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000014848 (Evidence)
Ensembl Gene Model ENSMUSG00000005089 (Evidence)
Entrez Gene 20511 (Evidence)
DFCI TC1582636, TC1591406, TC1597211, TC1636524, TC1656818, TC1678964
DoTS DT.103566437, DT.50315921, DT.529533, DT.91336833, DT.94237556, DT.97409810
NIA Mouse Gene Index U042335, U044556, U068445
Consensus CDS Project CCDS16469.1, CCDS38188.1, CCDS38189.1
International Mouse Phenotyping Consortium Status Slc1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014848 VEGA Gene Model | MGI Sequence Detail 132126 C57BL/6J ±  kb
transcript OTTMUST00000035265 VEGA | MGI Sequence Detail 11595 Not Applicable 
polypeptide OTTMUSP00000015765 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(10) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(1879 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014973 excitatory amino acid transporter 2
References
(Earliest) J:21903 Kirschner MA, et al., Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics. 1994 Nov 15;24(2):218-24
(Latest) J:218776 Morrison BM, et al., Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush. Exp Neurol. 2015 Jan;263:325-38
All references(91)
Other
accession IDs
MGD-MRK-16275, MGD-MRK-18762, MGI:1920182, MGI:1926215, MGI:2138846

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory