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Slc1a2
Gene Detail
 Symbol
Name
ID
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
MGI:101931
Synonyms 1700091C19Rik, 2900019G14Rik, Eaat2, GLT1, GLT-1, MGLT1
Feature Type protein coding gene
Genetic Map
Chromosome 2
54.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:102658659-102790784 bp, + strand
From VEGA annotation of GRCm38

  132126 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a2

Human
homologs
Human Homolog SLC1A2, solute carrier family 1 (glial high affinity glutamate transporter), member 2
NCBI Gene ID 6506
neXtProt AC  NX_P43004
Human Synonyms  EAAT2, GLT-1
Human Chr (Location)  11p13-p12; chr11:35251205-35420063 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Slc1a2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display spontaneous seizures often leading to death as well as a succeptibility to neuronal degeneration.
 
Interactions
Slc1a2 interacts with 599 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process adult behavior, cellular response to extracellular stimulus, ...
Component axolemma, axon, ...
Function glutamate:sodium symporter activity, high-affinity glutamate transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (345)    Tissues (177)    Images (26)
Theiler Stages: 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 286
RT-PCR 59
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(24) Primer pair(4) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000014848 (Evidence)
Ensembl Gene ModelENSMUSG00000005089 (Evidence)
Entrez Gene20511 (Evidence)
DFCITC1582636, TC1591406, TC1597211, TC1636524, TC1656818, TC1678964
DoTSDT.103566437, DT.50315921, DT.529533, DT.91336833, DT.94237556, DT.97409810
NIA Mouse Gene IndexU042335, U044556, U068445
Consensus CDS ProjectCCDS16469.1, CCDS38188.1, CCDS38189.1
International Mouse Knockout Project StatusSlc1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014848 VEGA Gene Model | MGI Sequence Detail 132126 C57BL/6J ±  kb
transcript OTTMUST00000035265 VEGA | MGI Sequence Detail 11595 Not Applicable 
polypeptide OTTMUSP00000015765 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(12) UniProt(10)
Polymorphisms RFLP(1) : SNPs within 2kb(1879 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014973 excitatory amino acid transporter 2
References (Earliest) J:21903 Kirschner MA, et al., Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics. 1994 Nov 15;24(2):218-24
(Latest) J:211303 Foran E, et al., Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia. 2014 Aug;62(8):1241-53
All references(85)
Other
accession IDs
MGD-MRK-16275, MGD-MRK-18762, MGI:1920182, MGI:1926215, MGI:2138846

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory