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Slc1a2 Gene Detail
Summary
  • Symbol
    Slc1a2
  • Name
    solute carrier family 1 (glial high affinity glutamate transporter), member 2
  • Synonyms
    1700091C19Rik, 2900019G14Rik, Eaat2, GLT1, GLT-1, MGLT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101931
    NCBI Gene: 20511
  • Gene Overview
    MyGene.info: SLC1A2
  • Alliance
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:102658659-102790784 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1857 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101931
protein coding gene Chr2:102658594-102790784 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026198
protein coding gene Chr2:104583630-104721646 (+)
A/J MGP_AJ_G0026159
protein coding gene Chr2:100287053-100419701 (+)
AKR/J MGP_AKRJ_G0026140
protein coding gene Chr2:102997570-103130867 (+)
BALB/cJ MGP_BALBcJ_G0026168
protein coding gene Chr2:100562123-100694513 (+)
C3H/HeJ MGP_C3HHeJ_G0025919
protein coding gene Chr2:103363643-103500106 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026619
protein coding gene Chr2:108102460-108245440 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024010
protein coding gene Chr2:95962924-96093867 (+)
CAST/EiJ MGP_CASTEiJ_G0025384
protein coding gene Chr2:103803831-103941718 (+)
CBA/J MGP_CBAJ_G0025897
protein coding gene Chr2:111808500-111947587 (+)
DBA/2J MGP_DBA2J_G0026033
protein coding gene Chr2:99847695-99980998 (+)
FVB/NJ MGP_FVBNJ_G0025996
protein coding gene Chr2:98850179-98982339 (+)
LP/J MGP_LPJ_G0026137
protein coding gene Chr2:104733841-104870498 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026022
protein coding gene Chr2:115772700-115908176 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026673
protein coding gene Chr2:103219268-103351200 (+)
PWK/PhJ MGP_PWKPhJ_G0025119
protein coding gene Chr2:99348160-99479759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024920
protein coding gene Chr2:102438577-102584331 (+)
WSB/EiJ MGP_WSBEiJ_G0025451
protein coding gene Chr2:103923199-104054584 (+)



Homology
more
  • Human Ortholog
    SLC1A2, solute carrier family 1 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC1A2, solute carrier family 1 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAAT2, EIEE41, GLT-1, HBGT
  • Links
    NCBI Gene ID: 6506
    neXtProt AC: NX_P43004
    UniProt: P43004

  • Chr Location
    11p13; chr11:35251205-35420063 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display spontaneous seizures often leading to death as well as a succeptibility to neuronal degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005089 Ensembl Gene Model | MGI Sequence Detail 132126 C57BL/6J ±  kb
    transcript ENSMUST00000080210 Ensembl | MGI Sequence Detail 11595 Not Applicable  
    polypeptide ENSMUSP00000079100 Ensembl | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 25
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16275, MGD-MRK-18762, MGI:1920182, MGI:1926215, MGI:2138846
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 18
      Gene Ontology 14
      Phenotypes 37
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:258726 Ottestad-Hansen S, et al., The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia. 2018 May;66(5):951-970

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory