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Slc1a2 Gene Detail
Summary
  • Symbol
    Slc1a2
  • Name
    solute carrier family 1 (glial high affinity glutamate transporter), member 2
  • Synonyms
    1700091C19Rik, 2900019G14Rik, Eaat2, GLT1, GLT-1, MGLT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101931
    NCBI Gene: 20511
  • Gene Overview
    MyGene.info: SLC1A2
Location & Maps
more
  • Sequence Map
    Chr2:102658659-102790784 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      132126 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.13 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC1A2, solute carrier family 1 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC1A2, solute carrier family 1 member 2
    Orthology source: HomoloGene
  • Synonyms
    EAAT2, GLT-1, HBGT
  • Links
    NCBI Gene ID: 6506
    neXtProt AC: NX_P43004

  • Chr Location
    11p13; chr11:35251205-35420063 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Slc1a2
  • Incidental Mutations
Mice homozygous for disruptions in this gene display spontaneous seizures often leading to death as well as a succeptibility to neuronal degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014848 VEGA Gene Model | MGI Sequence Detail 132126 C57BL/6J ±  kb
transcript OTTMUST00000035265 VEGA | MGI Sequence Detail 11595 Not Applicable  
polypeptide OTTMUSP00000015765 VEGA | MGI Sequence Detail 572 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1857 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000014973 excitatory amino acid transporter 2
  • InterPro Domains
    IPR001991 Sodium:dicarboxylate symporter
    IPR018107 Sodium:dicarboxylate symporter, conserved site
Molecular
Reagents
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  • All nucleic 30
    cDNA 24
    Primer pair 4
    Other 2

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-16275, MGD-MRK-18762, MGI:1920182, MGI:1926215, MGI:2138846
References
more
  • Summaries
    All 92
    Developmental Gene Expression 16
    Gene Ontology 11
    Phenotypes 32
  • Earliest
    J:21903 Kirschner MA, et al., Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics. 1994 Nov 15;24(2):218-24
  • Latest
    J:221590 Petr GT, et al., Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015 Apr 1;35(13):5187-201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory