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Dlx6 Gene Detail
Summary
  • Symbol
    Dlx6
  • Name
    distal-less homeobox 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:101927
    NCBI Gene: 13396
  • Gene Overview
    MyGene.info: DLX6
Location & Maps
more
  • Genetic Map
    Chromosome 6, 2.83 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DLX6, distal-less homeobox 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLX6, distal-less homeobox 6
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 1750
    neXtProt AC: NX_P56179

  • Chr Location
    7q22; chr7:97005978-97011040 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 87855
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DLX6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Dlx6 mouse models

Human Disease Mouse Models
       Split-Hand/Foot Malformation 1; SHFM1   OMIM: 183600 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 2 alleles in 1 genetic background
    13 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Dlx6
  • Incidental Mutations
Homozygotes for targeted null mutations at both Dlx5 and Dlx6 exhibit bilateral ectrodactyly, homeotic transformation of the lower jaw into an upper jaw, and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034244 VEGA Gene Model | MGI Sequence Detail 5235 C57BL/6J ±  kb
transcript OTTMUST00000086975 VEGA | MGI Sequence Detail 2216 Not Applicable  
polypeptide OTTMUSP00000047152 VEGA | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    Genomic 2
    cDNA 12
    Primer pair 1
    Other 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-18758
References
more
  • Summaries
    All 101
    Developmental Gene Expression 72
    Diseases 2
    Gene Ontology 8
    Phenotypes 25
  • Earliest
    J:17176 Simeone A, et al., Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
  • Latest
    J:227622 Bellessort B, et al., Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis. Hum Mol Genet. 2016 Jan 1;25(1):97-108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory