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Dlx6 Gene Detail
Summary
  • Symbol
    Dlx6
  • Name
    distal-less homeobox 6
Location &
Maps
more
  • Sequence Map
    Chr6:6863272-6867965 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 2.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101927
 protein coding gene Chr6:6863272-6868568 (+)
129S1/SvImJ ENSMUSG00200001627
 protein coding gene Chr6:3948837-3954074 (+)
A/J ENSMUSG00195001960
 protein coding gene Chr6:3829975-3835214 (+)
AKR/J ENSMUSG00220020242
 protein coding gene Chr6:3736688-3741933 (+)
BALB/cJ ENSMUSG00180001332
 protein coding gene Chr6:3965849-3971084 (+)
C3H/HeJ ENSMUSG00175007265
 protein coding gene Chr6:3794612-3799854 (+)
C57BL/6NJ ENSMUSG00215011240
 protein coding gene Chr6:3917915-3923151 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028088
 protein coding gene Chr6:3254967-3260244 (+)
CAST/EiJ ENSTCUG00005025756
 protein coding gene Chr6:3815017-3820239 (+)
CBA/J ENSMUSG00210021222
 protein coding gene Chr6:3731303-3736542 (+)
DBA/2J ENSMUSG00185024661
 protein coding gene Chr6:3924380-3929622 (+)
FVB/NJ ENSMUSG00205014929
 protein coding gene Chr6:3933135-3938366 (+)
JF1/MsJ ENSUMUG00000011765
 protein coding gene Chr6:3917622-3922843 (+)
LP/J ENSMUSG00230015041
 protein coding gene Chr6:4924026-4929256 (+)
NOD/ShiLtJ ENSMUSG00190015467
 protein coding gene Chr6:3649322-3654559 (+)
NZO/HlLtJ ENSMUSG00225017783
 protein coding gene Chr6:6755460-6760701 (+)
PWK/PhJ ENSLUMG00010023491
 protein coding gene Chr6:3713369-3718582 (+)
SPRET/EiJ ENSMSPG00010002809
 protein coding gene Chr6:3655692-3659898 (+)
WSB/EiJ ENSIUOG00005004032
 protein coding gene Chr6:3912328-3917572 (+)



Homology
more
  • Human Ortholog
    DLX6, distal-less homeobox 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLX6, distal-less homeobox 6
  • Links
    NCBI Gene ID: 1750
    UniProt: P56179

  • Chr Location
    7q21.3; chr7:97005553-97011040 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dlx6 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 2 alleles in 1 genetic background
    13 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations at both Dlx5 and Dlx6 exhibit bilateral ectrodactyly, homeotic transformation of the lower jaw into an upper jaw, and perinatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1000
  • Tissues
    264
  • cDNA Data
    13
  • Literature Summary
    94
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13396 NCBI Gene Model | MGI Sequence Detail 4694 C57BL/6J ±  kb
    transcript NM_010057 RefSeq | MGI Sequence Detail 1128 C57BL/6  
    polypeptide P70397 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 3
      cDNA 18
      Primer pair 11
      Other 10
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18758
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 94
      Diseases 2
      Gene Ontology 12
      Phenotypes 38
    • Earliest
      J:17176 Simeone A, et al., Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
    • Latest
      J:377197 Denipah-Cook Q, et al., PRDM paralogs are required for Meckel's cartilage formation during mandibular bone development. Dev Biol. 2025 Dec 4;530:210-223
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory