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Dlx6
Gene Detail
 Symbol
Name
ID
Dlx6
distal-less homeobox 6
MGI:101927
Feature Type protein coding gene
Genetic Map
Chromosome 6
2.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:6863334-6868568 bp, + strand
From VEGA annotation of GRCm38

  5235 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Dlx6

Human
homologs
Human Homolog DLX6, distal-less homeobox 6
NCBI Gene ID 1750
neXtProt AC  NX_P56179
Human Chr (Location)  7q22; chr7:97005978-97011040 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygotes for targeted null mutations at both Dlx5 and Dlx6 exhibit bilateral ectrodactyly, homeotic transformation of the lower jaw into an upper jaw, and perinatal lethality.
 
Human Diseases Modeled Using Mouse Dlx6 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process anatomical structure formation involved in morphogenesis, embryonic limb morphogenesis, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (238)    Tissues (198)    Images (57)
Theiler Stages: 14, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 226
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(12) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034244 (Evidence)
Ensembl Gene ModelENSMUSG00000029754 (Evidence)
Entrez Gene13396 (Evidence)
NIA Mouse Gene IndexU006522
Consensus CDS ProjectCCDS51719.1
International Mouse Knockout Project StatusDlx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034244 VEGA Gene Model | MGI Sequence Detail 5235 C57BL/6J ±  kb
transcript OTTMUST00000086975 VEGA | MGI Sequence Detail 2216 Not Applicable 
polypeptide OTTMUSP00000047152 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006532 homeobox protein DLX-6
References (Earliest) J:17176 Simeone A, et al., Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
(Latest) J:204597 Berghoff EG, et al., Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes. Development. 2013 Nov;140(21):4407-16
All references(96)
Other
accession IDs
MGD-MRK-18758

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory