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Tnc
Gene Detail
Symbol

Name
ID
Tnc
tenascin C
MGI:101922
Synonyms
C130033P17Rik, cytotactin, hexabrachion, Hxb, tenascin-C, TN, TN-C
Feature Type
protein coding gene
Genetic Map
Chromosome 4
34.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr4:63959785-64020725 bp, - strand
From VEGA annotation of GRCm38

  60941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55636  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TNC
Gene Tree: Tnc

Human
homologs
TNC, tenascin C
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3371
neXtProt AC: NX_P24821

Human Synonyms: 150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C

Human Chr (Location): 9q33; chr9:115019575-115118257 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TNC

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission.
 
Interactions
Tnc interacts with 188 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process bud outgrowth involved in lung branching, cell adhesion, ...
Component basement membrane, extracellular matrix, ...
Function fibronectin binding, syndecan binding
External Resources: FuncBase
Expression
Literature Summary: (126 records)
Data Summary: Results (938)    Tissues (272)    Images (172)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 158
RNA in situ 570
In situ reporter (knock in) 14
Northern blot 88
Western blot 31
RT-PCR 77
cDNA source data(53)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TNC ; Xenbase tnc ; ZFIN tnc    NEW 
Molecular
reagents
All nucleic(90) Genomic(2) cDNA(59) Primer pair(21) Other(8)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000302 (Evidence)
Ensembl Gene Model ENSMUSG00000028364 (Evidence)
Entrez Gene 21923 (Evidence)
DFCI TC1573025, TC1588200, TC1601619, TC1638095
DoTS DT.101378344, DT.94314498, DT.534569, DT.94314494
NIA Mouse Gene Index U025161, U350070
Consensus CDS Project CCDS18265.1
International Mouse Phenotyping Consortium Status Tnc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000302 VEGA Gene Model | MGI Sequence Detail 60941 C57BL/6J ±  kb
transcript OTTMUST00000000774 VEGA | MGI Sequence Detail 7106 Not Applicable 
polypeptide OTTMUSP00000000342 VEGA | MGI Sequence Detail 2110 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(6)
Polymorphisms
RFLP(7) : SNPs within 2kb(582 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000016471 tenascin
References
(Earliest) J:152889 Aufderheide E, et al., Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol. 1987 Jul;105(1):599-608
(Latest) J:220409 Hendaoui I, et al., Tenascin-C is required for normal Wnt/beta-catenin signaling in the whisker follicle stem cell niche. Matrix Biol. 2014 Nov;40:46-53
All references(259)
Other
accession IDs
MGD-MRK-11022, MGD-MRK-15040, MGD-MRK-18751, MGI:2140328, MGI:3028077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory