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Tnc Gene Detail
Summary
  • Symbol
    Tnc
  • Name
    tenascin C
  • Synonyms
    C130033P17Rik, cytotactin, hexabrachion, Hxb, tenascin-C, TN, TN-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:101922
    NCBI Gene: 21923
  • Gene Overview
    MyGene.info: TNC
Location & Maps
more
  • Sequence Map
    Chr4:63959785-64020725 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60941 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 34.06 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    TNC, tenascin C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNC, tenascin C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C
  • Links
    NCBI Gene ID: 3371
    neXtProt AC: NX_P24821

  • Chr Location
    9q33; chr9:115019575-115118257 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TNC associations

Human Disease Mouse Models
       Deafness, Autosomal Dominant 56; DFNA56   OMIM: 615629
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 6 genetic backgrounds
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000302 VEGA Gene Model | MGI Sequence Detail 60941 C57BL/6J ±  kb
transcript OTTMUST00000000774 VEGA | MGI Sequence Detail 7106 Not Applicable  
polypeptide OTTMUSP00000000342 VEGA | MGI Sequence Detail 2110 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    581 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016471 tenascin
  • InterPro Domains
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR013111 EGF-like domain, extracellular
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR033078 Tenascin-C
Molecular
Reagents
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  • All nucleic 90
    Genomic 2
    cDNA 59
    Primer pair 21
    Other 8

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11022, MGD-MRK-15040, MGD-MRK-18751, MGI:2140328, MGI:3028077
References
more
  • Summaries
    All 263
    Developmental Gene Expression 131
    Gene Ontology 15
    Phenotypes 68
  • Earliest
    J:152889 Aufderheide E, et al., Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol. 1987 Jul;105(1):599-608
  • Latest
    J:229394 Bernier-Latmani J, et al., DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest. 2015 Dec;125(12):4572-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory