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Tnc
Gene Detail
Symbol

Name
ID
Tnc
tenascin C
MGI:101922
Synonyms
C130033P17Rik, cytotactin, hexabrachion, Hxb, tenascin-C, TN, TN-C
Feature Type
protein coding gene
Genetic Map
Chromosome 4
34.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr4:63959785-64020725 bp, - strand
From VEGA annotation of GRCm38

  60941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55636  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tnc

Human
homologs
Human Homolog TNC, tenascin C
NCBI Gene ID 3371
neXtProt AC  NX_P24821
Human Synonyms  150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C
Human Chr (Location)  9q33; chr9:115019575-115118257 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TNC
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission.
 
Interactions
Tnc interacts with 188 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process bud outgrowth involved in lung branching, cell adhesion, ...
Component basement membrane, extracellular matrix, ...
Function fibronectin binding, syndecan binding
External Resources: FuncBase
Expression
Literature Summary: (121 records)
Data Summary: Results (903)    Tissues (253)    Images (159)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 129
RNA in situ 570
In situ reporter (knock in) 14
Northern blot 84
Western blot 31
RT-PCR 75
cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(89) Genomic(2) cDNA(59) Primer pair(20) Other(8)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000302 (Evidence)
Ensembl Gene ModelENSMUSG00000028364 (Evidence)
Entrez Gene21923 (Evidence)
DFCITC1601619, TC1638095, TC1588200, TC1573025
DoTSDT.534569, DT.94314494, DT.94314498, DT.101378344
NIA Mouse Gene IndexU350070, U025161
Consensus CDS ProjectCCDS18265.1
International Mouse Knockout Project StatusTnc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000302 VEGA Gene Model | MGI Sequence Detail 60941 C57BL/6J ±  kb
transcript OTTMUST00000000774 VEGA | MGI Sequence Detail 7106 Not Applicable 
polypeptide OTTMUSP00000000342 VEGA | MGI Sequence Detail 2110 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(10) UniProt(11)
Polymorphisms
RFLP(7) : SNPs within 2kb(582 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000016471 tenascin
References
(Earliest) J:152889 Aufderheide E, et al., Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol. 1987 Jul;105(1):599-608
(Latest) J:210162 Kimura T, et al., Tenascin C protects aorta from acute dissection in mice. Sci Rep. 2014;4:4051
All references(253)
Other
accession IDs
MGD-MRK-11022, MGD-MRK-15040, MGD-MRK-18751, MGI:2140328, MGI:3028077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory