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Ap1g1 Gene Detail
Summary
  • Symbol
    Ap1g1
  • Name
    adaptor protein complex AP-1, gamma 1 subunit
  • Synonyms
    Adtg, D8Ertd374e, gamma-adaptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:101919
    NCBI Gene: 11765
  • Gene Overview
    MyGene.info: AP1G1
Location & Maps
more
  • Sequence Map
    Chr8:109778554-109864204 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85651 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.26 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AP1G1, adaptor related protein complex 1 gamma 1 subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AP1G1, adaptor related protein complex 1 gamma 1 subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADTG, CLAPG1
  • Links
    NCBI Gene ID: 164
    neXtProt AC: NX_O43747

  • Chr Location
    16q23; chr16:71729000-71809073 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete embryonic lethality before implantation. Heterozygotes display slow postnatal weight gain, decreased CD4-positive, alpha beta T cell number in the thymus, and decreased body size up to 10 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037661 VEGA Gene Model | MGI Sequence Detail 85651 C57BL/6J ±  kb
transcript OTTMUST00000097224 VEGA | MGI Sequence Detail 6899 Not Applicable  
polypeptide OTTMUSP00000054485 VEGA | MGI Sequence Detail 825 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    269 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-18748, MGI:1196381, MGI:2142410, MGI:2142715, MGI:2142805
References
more
  • Summaries
    All 53
    Developmental Gene Expression 6
    Gene Ontology 15
    Phenotypes 10
  • Earliest
    J:21440 Robinson MS, Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. J Cell Biol. 1990 Dec;111(6 Pt 1):2319-26
  • Latest
    J:230572 Johnson KR, et al., A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice. Mamm Genome. 2016 Apr 18;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory