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Ap1g1 Gene Detail
Summary
  • Symbol
    Ap1g1
  • Name
    adaptor protein complex AP-1, gamma 1 subunit
  • Synonyms
    Adtg, D8Ertd374e, gamma-adaptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:101919
    NCBI Gene: 11765
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110505215-110590842 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101919
protein coding gene Chr8:110505186-110590842 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034114
protein coding gene Chr8:112390415-112480537 (+)
A/J MGP_AJ_G0034093
protein coding gene Chr8:107835126-107921782 (+)
AKR/J MGP_AKRJ_G0034020
protein coding gene Chr8:110995004-111084797 (+)
BALB/cJ MGP_BALBcJ_G0034087
protein coding gene Chr8:108042199-108128520 (+)
C3H/HeJ MGP_C3HHeJ_G0033798
protein coding gene Chr8:111701039-111794341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034607
protein coding gene Chr8:116353327-116449494 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031549
protein coding gene Chr8:100864236-100951526 (+)
CAST/EiJ MGP_CASTEiJ_G0033125
protein coding gene Chr8:111302845-111395221 (+)
CBA/J MGP_CBAJ_G0033772
protein coding gene Chr8:120268119-120362570 (+)
DBA/2J MGP_DBA2J_G0033927
protein coding gene Chr8:107160662-107247603 (+)
FVB/NJ MGP_FVBNJ_G0033871
protein coding gene Chr8:106108519-106197513 (+)
LP/J MGP_LPJ_G0034017
protein coding gene Chr8:112562646-112657281 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033917
protein coding gene Chr8:123284514-123376836 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034626
protein coding gene Chr8:110956665-111046059 (+)
PWK/PhJ MGP_PWKPhJ_G0032828
protein coding gene Chr8:106721696-106803956 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032667
protein coding gene Chr8:109642269-109727449 (+)
WSB/EiJ MGP_WSBEiJ_G0033241
protein coding gene Chr8:111640185-111731277 (+)



Homology
more
  • Human Ortholog
    AP1G1, adaptor related protein complex 1 subunit gamma 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP1G1, adaptor related protein complex 1 subunit gamma 1
  • Synonyms
    ADTG, CLAPG1, USRISD
  • Links
    NCBI Gene ID: 164
    neXtProt AC: NX_O43747
    UniProt: O43747

  • Chr Location
    16q22.2; chr16:71729000-71809201 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete embryonic lethality before implantation. Heterozygotes display slow postnatal weight gain, decreased CD4-positive, alpha beta T cell number in the thymus, and decreased body size up to 10 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11765 NCBI Gene Model | MGI Sequence Detail 85628 C57BL/6J ±  kb
    transcript NM_009677 RefSeq | MGI Sequence Detail 6891 ZRU/MplStud  
    polypeptide P22892 UniProt | EBI | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-18748, MGI:1196381, MGI:2142410, MGI:2142715, MGI:2142805
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 9
      Gene Ontology 18
      Phenotypes 12
    • Earliest
      J:21440 Robinson MS, Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. J Cell Biol. 1990 Dec;111(6 Pt 1):2319-26
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory