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Calb2
Gene Detail
Symbol

Name
ID
Calb2
calbindin 2
MGI:101914
Synonyms
calretinin, CR
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:110142539-110168206 bp, - strand
From Ensembl annotation of GRCm38

  25668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: calretinin
Gene Tree: Calb2

Human
homologs
Human Homolog CALB2, calbindin 2
NCBI Gene ID 794
neXtProt AC  NX_P22676
Human Synonyms  CAB29, CAL2, CR
Human Chr (Location)  16q22.2; chr16:71358713-71390438 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants showed normal growth, normal brain histology, and generally normal behavior. Impaired motor coordination was observed in wheel running in young and old mutant mice, and progressive impairment was seen on the runway and horizontal stationary rod tests in older mice. Abnormalities are observed in Purkinje cell firing, altering both simple and complex spikes.
 
Interactions
Calb2 interacts with 83 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cytosolic calcium ion homeostasis
Component cytoplasm, cytosol, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (415 records)
Data Summary: Results (314)    Tissues (191)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 79
RNA in situ 189
RT-PCR 46
cDNA source data(39)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(2) cDNA(40) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003657 (Evidence)
Entrez Gene12308 (Evidence)
UniGene2755
DFCITC1576082
DoTSDT.40164012
NIA Mouse Gene IndexU030243
Consensus CDS ProjectCCDS22661.1
International Mouse Knockout Project StatusCalb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003657 Ensembl Gene Model | MGI Sequence Detail 25668 C57BL/6J ±  kb
transcript ENSMUST00000003754 Ensembl | MGI Sequence Detail 1430 Not Applicable 
polypeptide ENSMUSP00000003754 Ensembl | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000004968 calretinin
References
(Earliest) J:17458 Ninomiya T, et al., Mouse fetal trisomy 13 and hypotrophy of the spinal cord: effect on calbindin-D28k and calretinin expressed by neurons of the spinal cord and dorsal root ganglia. Neuroscience. 1993 Dec;57(4):1109-20
(Latest) J:214707 Medina-Bolivar C, et al., Cortical hypoplasia and ventriculomegaly of p73-deficient mice: Developmental and adult analysis. J Comp Neurol. 2014 Aug 1;522(11):2663-79
All references(466)
Other
accession IDs
MGD-MRK-18743

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory