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Calb2
Gene Detail
Symbol

Name
ID
Calb2
calbindin 2
MGI:101914
Synonyms
calretinin, CR
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:110142539-110168206 bp, - strand
From Ensembl annotation of GRCm38

  25668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CALB2
Protein SuperFamily: calretinin
Gene Tree: Calb2

Human
homologs
CALB2, calbindin 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 794
neXtProt AC: NX_P22676

Human Synonyms: CAB29, CAL2, CR

Human Chr (Location): 16q22.2; chr16:71358713-71390438 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous targeted mutants showed normal growth, normal brain histology, and generally normal behavior. Impaired motor coordination was observed in wheel running in young and old mutant mice, and progressive impairment was seen on the runway and horizontal stationary rod tests in older mice. Abnormalities are observed in Purkinje cell firing, altering both simple and complex spikes.
 
Interactions
Calb2 interacts with 83 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cytosolic calcium ion homeostasis
Component cytoplasm, cytosol, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (425 records)
Data Summary: Results (339)    Tissues (205)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 98
RNA in situ 195
RT-PCR 46
cDNA source data(39)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase calb2 ; ZFIN calb2a, calb2b    NEW 
Molecular
reagents
All nucleic(45) Genomic(2) cDNA(40) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000003657 (Evidence)
Entrez Gene 12308 (Evidence)
UniGene 2755
DFCI TC1576082
DoTS DT.40164012
NIA Mouse Gene Index U030243
Consensus CDS Project CCDS22661.1
International Mouse Phenotyping Consortium Status Calb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003657 Ensembl Gene Model | MGI Sequence Detail 25668 C57BL/6J ±  kb
transcript ENSMUST00000003754 Ensembl | MGI Sequence Detail 1430 Not Applicable 
polypeptide ENSMUSP00000003754 Ensembl | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000004968 calretinin
References
(Earliest) J:17458 Ninomiya T, et al., Mouse fetal trisomy 13 and hypotrophy of the spinal cord: effect on calbindin-D28k and calretinin expressed by neurons of the spinal cord and dorsal root ganglia. Neuroscience. 1993 Dec;57(4):1109-20
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(477)
Other
accession IDs
MGD-MRK-18743

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory