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Dad1 Gene Detail
Summary
  • Symbol
    Dad1
  • Name
    defender against cell death 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101912
    NCBI Gene: 13135
  • Gene Overview
    MyGene.info: DAD1
Location & Maps
more
  • Sequence Map
    Chr14:54235479-54254104 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18626 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DAD1, defender against cell death 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAD1, defender against cell death 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OST2
  • Links
    NCBI Gene ID: 1603
    neXtProt AC: NX_P61803

  • Chr Location
    14q11.2; chr14:22564907-22589237 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    7
  • Genomic Mutations
    1 involving Dad1
Homozygous null mice display fully penetrant embryonic lethality before somite formation and impaired growth. Heterozygous null mice display incompletely penetrant embryonic lethality, impaired embryonic growth, syndactyly, and mild thymic hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033740 VEGA Gene Model | MGI Sequence Detail 18626 C57BL/6J ±  kb
transcript OTTMUST00000085008 VEGA | MGI Sequence Detail 878 Not Applicable  
polypeptide OTTMUSP00000045877 VEGA | MGI Sequence Detail 113 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    264 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006266 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
  • EC
  • InterPro Domains
    IPR003038 DAD/Ost2
Molecular
Reagents
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  • All nucleic 170
    cDNA 168
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18741, MGI:2145618
References
more
  • Summaries
    All 41
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:22684 Nakashima T, et al., Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol Cell Biol. 1993 Oct;13(10):6367-74
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory