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Dad1
Gene Detail
 Symbol
Name
ID
Dad1
defender against cell death 1
MGI:101912
Feature Type protein coding gene
Genetic Map
Chromosome 14
27.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:54235479-54254104 bp, - strand
From VEGA annotation of GRCm38

  18626 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1027  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dolichyl-diphosphooligosaccharide--protein glycosyltransferase, DAD1/Ost2 subunit
Gene Tree: Dad1

Human
homologs
Human Homolog DAD1, defender against cell death 1
NCBI Gene ID 1603
neXtProt AC  NX_P61803
Human Synonyms  OST2
Human Chr (Location)  14q11.2; chr14:22564907-22589237 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
 
Homozygous null mice display fully penetrant embryonic lethality before somite formation and impaired growth. Heterozygous null mice display incompletely penetrant embryonic lethality, impaired embryonic growth, syndactyly, and mild thymic hypoplasia.
 
Interactions
Dad1 interacts with 283 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process apoptotic process, blastocyst development, ...
Component endoplasmic reticulum, extracellular vesicular exosome, ...
Function dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (315)    Tissues (175)    Images (36)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 258
Northern blot 4
RT-PCR 46
RNase protection 7
cDNA source data(167)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(170) cDNA(168) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033740 (Evidence)
Ensembl Gene ModelENSMUSG00000022174 (Evidence)
Entrez Gene13135 (Evidence)
UniGene319038
DFCITC1572982, TC1674711, TC1684740
DoTSDT.101155158, DT.102539329, DT.55101200, DT.94306332
NIA Mouse Gene IndexU035548
EC2.4.99.18
Consensus CDS ProjectCCDS27084.1
International Mouse Knockout Project StatusDad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033740 VEGA Gene Model | MGI Sequence Detail 18626 C57BL/6J ±  kb
transcript OTTMUST00000085008 VEGA | MGI Sequence Detail 878 Not Applicable 
polypeptide OTTMUSP00000045877 VEGA | MGI Sequence Detail 113 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(271 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003038 DAD/Ost2
Protein Ontology PR:000006266 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
References (Earliest) J:22684 Nakashima T, et al., Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol Cell Biol. 1993 Oct;13(10):6367-74
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)
Other
accession IDs
MGD-MRK-18741, MGI:2145618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory