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Dusp2 Gene Detail
Summary
  • Symbol
    Dusp2
  • Name
    dual specificity phosphatase 2
  • Synonyms
    PAC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101911
    NCBI Gene: 13537
  • Gene Overview
    MyGene.info: DUSP2
Location & Maps
more
  • Sequence Map
    Chr2:127336159-127338376 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2218 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.93 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DUSP2, dual specificity phosphatase 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DUSP2, dual specificity phosphatase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAC1, PAC-1
  • Links
    NCBI Gene ID: 1844
    neXtProt AC: NX_Q05923

  • Chr Location
    2q11; chr2:96143169-96145440 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Dusp2
  • Incidental Mutations
    APF , CvDC
Homozygous mutation of this gene results in reduced inflammatory responses in induced rheumatoid arthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016021 VEGA Gene Model | MGI Sequence Detail 2218 C57BL/6J ±  kb
transcript OTTMUST00000038193 VEGA | MGI Sequence Detail 1617 Not Applicable  
polypeptide OTTMUSP00000017127 VEGA | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006746 dual specificity protein phosphatase 2
  • EC
  • InterPro Domains
    IPR020417 Atypical dual specificity phosphatase
    IPR024950 Dual specificity phosphatase
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR001763 Rhodanese-like domain
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
less
  • All nucleic 20
    Genomic 2
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18740
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:22010 Rohan PJ, et al., PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993 Mar 19;259(5102):1763-6
  • Latest
    J:225319 Lancaster GI, et al., The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice. PLoS One. 2014;9(11):e111524

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory