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Dusp2
Gene Detail
Symbol

Name
ID
Dusp2
dual specificity phosphatase 2
MGI:101911
Synonyms
PAC1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:127336159-127338376 bp, + strand
From VEGA annotation of GRCm38

  2218 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: DUSP2
Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp2

Human
homologs
DUSP2, dual specificity phosphatase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1844
neXtProt AC: NX_Q05923

Human Synonyms: PAC1, PAC-1

Human Chr (Location): 2q11; chr2:96143169-96145440 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutation of this gene results in reduced inflammatory responses in induced rheumatoid arthritis.
 
Interactions
Dusp2 interacts with 118 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process dephosphorylation, endoderm formation, ...
Component nucleus
Function hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016021 (Evidence)
Ensembl Gene Model ENSMUSG00000027368 (Evidence)
Entrez Gene 13537 (Evidence)
UniGene 4729
DFCI TC1582558
DoTS DT.528764
NIA Mouse Gene Index U002434
EC 3.1.3.16, 3.1.3.48
Consensus CDS Project CCDS16699.1
International Mouse Phenotyping Consortium Status Dusp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016021 VEGA Gene Model | MGI Sequence Detail 2218 C57BL/6J ±  kb
transcript OTTMUST00000038193 VEGA | MGI Sequence Detail 1617 Not Applicable 
polypeptide OTTMUSP00000017127 VEGA | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020417 Atypical dual specificity phosphatase
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006746 dual specificity protein phosphatase 2
References
(Earliest) J:22010 Rohan PJ, et al., PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993 Mar 19;259(5102):1763-6
(Latest) J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
All references(32)
Other
accession IDs
MGD-MRK-18740

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory