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Dusp2
Gene Detail
Symbol

Name
ID
Dusp2
dual specificity phosphatase 2
MGI:101911
Synonyms
PAC1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:127336159-127338376 bp, + strand
From VEGA annotation of GRCm38

  2218 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp2

Human
homologs
Human Homolog DUSP2, dual specificity phosphatase 2
NCBI Gene ID 1844
neXtProt AC  NX_Q05923
Human Synonyms  PAC1, PAC-1
Human Chr (Location)  2q11; chr2:96143169-96145440 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in reduced inflammatory responses in induced rheumatoid arthritis.
 
Interactions
Dusp2 interacts with 118 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process dephosphorylation, endoderm formation, ...
Component nucleus
Function hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016021 (Evidence)
Ensembl Gene ModelENSMUSG00000027368 (Evidence)
Entrez Gene13537 (Evidence)
UniGene4729
DFCITC1582558
DoTSDT.528764
NIA Mouse Gene IndexU002434
EC3.1.3.16, 3.1.3.48
Consensus CDS ProjectCCDS16699.1
International Mouse Knockout Project StatusDusp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016021 VEGA Gene Model | MGI Sequence Detail 2218 C57BL/6J ±  kb
transcript OTTMUST00000038193 VEGA | MGI Sequence Detail 1617 Not Applicable 
polypeptide OTTMUSP00000017127 VEGA | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020417 Atypical dual specificity phosphatase
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006746 dual specificity protein phosphatase 2
References
(Earliest) J:22010 Rohan PJ, et al., PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993 Mar 19;259(5102):1763-6
(Latest) J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
All references(34)
Other
accession IDs
MGD-MRK-18740

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory