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Gpr12
Gene Detail
Symbol

Name
ID
Gpr12
G-protein coupled receptor 12
MGI:101909
Synonyms
Gpcr01, Gpcr12, Gpcr20
Feature Type
protein coding gene
Genetic Map
Chromosome 5
85.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:146582151-146585239 bp, - strand
From Ensembl annotation of GRCm38

  3089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPR12
Protein SuperFamily: GPR6-like G protein-coupled receptor
Gene Tree: Gpr12

Human
homologs
GPR12, G protein-coupled receptor 12
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2835
neXtProt AC: NX_P47775

Human Synonyms: GPCR12, GPCR21, PPP1R84

Human Chr (Location): 13q12; chr13:26755200-26760785 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in obesity, increased cholesterol, glucose and triglyceride levels and decreased energy expenditure.
 
Human Diseases Modeled in Mice Using Gpr12 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gpr12 interacts with 149 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (64)    Tissues (34)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 64
cDNA source data(5)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100488444    NEW 
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(9)
Other database
links
Ensembl Gene Model ENSMUSG00000041468 (Evidence)
Entrez Gene 14738 (Evidence)
DFCI TC1586303, TC1716227
DoTS DT.60100428, DT.40139880
NIA Mouse Gene Index U026956
Consensus CDS Project CCDS19871.1
International Mouse Phenotyping Consortium Status Gpr12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041468 Ensembl Gene Model | MGI Sequence Detail 3089 C57BL/6J ±  kb
transcript ENSMUST00000036211 Ensembl | MGI Sequence Detail 2468 Not Applicable 
polypeptide ENSMUSP00000038245 Ensembl | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000599 G protein-coupled receptor 12
InterPro IPR000723 G protein-coupled receptor 3/6/12 orphan
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001636 G-protein coupled receptor 12
References
(Earliest) J:16169 Saeki Y, et al., Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993 Dec 27;336(2):317-22
(Latest) J:189831 Frank E, et al., Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice. PLoS One. 2012;7(8):e42395
All references(30)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16341, MGD-MRK-18738

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory