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Gpr12 Gene Detail
Summary
  • Symbol
    Gpr12
  • Name
    G-protein coupled receptor 12
  • Synonyms
    Gpcr01, Gpcr12, Gpcr20
  • Feature Type
    protein coding gene
  • IDs
    MGI:101909
    NCBI Gene: 14738
  • Gene Overview
    MyGene.info: GPR12
Location & Maps
more
  • Sequence Map
    Chr5:146582398-146585239 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 85.23 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GPR12, G protein-coupled receptor 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPR12, G protein-coupled receptor 12
    Orthology source: HomoloGene
  • Synonyms
    GPCR12, GPCR21, PPP1R84
  • Links
    NCBI Gene ID: 2835
    neXtProt AC: NX_P47775

  • Chr Location
    13q12; chr13:26755200-26760785 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gpr12 mouse models

Human Disease Mouse Models
       Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in obesity, increased cholesterol, glucose and triglyceride levels and decreased energy expenditure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055165 VEGA Gene Model | MGI Sequence Detail 2842 C57BL/6J ±  kb
transcript OTTMUST00000136606 VEGA | MGI Sequence Detail 1455 Not Applicable  
polypeptide OTTMUSP00000072077 VEGA | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    28 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001636 G-protein coupled receptor 12
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000599 G protein-coupled receptor 12
    IPR000723 G protein-coupled receptor 3/6/12 orphan
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-16341, MGD-MRK-18738
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:16169 Saeki Y, et al., Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993 Dec 27;336(2):317-22
  • Latest
    J:189831 Frank E, et al., Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice. PLoS One. 2012;7(8):e42395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory