Gpr12
Gene Detail

Symbol Name ID

Gpr12 G-protein coupled receptor 12 MGI:101909

Synonyms

Gpcr01, Gpcr12, Gpcr20

Feature Type

protein coding gene

Genetic Map

Chromosome 5

85.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:146582151-146585239 bp, - strand From Ensembl annotation of GRCm38   3089 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GPR6-like G protein-coupled receptor
Gene Tree: Gpr12

Human homologs

Human Homolog		GPR12, G protein-coupled receptor 12
NCBI Gene ID		2835
neXtProt AC		NX_P47775
Human Synonyms		GPCR12, GPCR21
Human Chr (Location)		13q12; chr13:27329337-27334922 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in obesity, increased cholesterol, glucose and triglyceride levels and decreased energy expenditure.

 
Human Diseases Modeled Using Mouse Gpr12 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cellular calcium ion homeostasis, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, phosphatidylcholine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (64)    Tissues (34)    Images (13)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	64

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000041468 (Evidence)
Entrez Gene	14738 (Evidence)
DFCI	TC1586303, TC1716227
DoTS	DT.40139880, DT.60100428
NIA Mouse Gene Index	U026956
Consensus CDS Project	CCDS19871.1
International Mouse Knockout Project Status	Gpr12

Sequences

Length	Strain/Species
genomic	ENSMUSG00000041468	Ensembl Gene Model | MGI Sequence Detail	3089	C57BL/6J
transcript	ENSMUST00000036211	Ensembl | MGI Sequence Detail	2468	Not Applicable
polypeptide	ENSMUSP00000038245	Ensembl | MGI Sequence Detail	334	Not Applicable

All sequences(23) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000599	G protein-coupled receptor 12
InterPro	IPR000723	G protein-coupled receptor 3/6/12 orphan
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001636	G-protein coupled receptor 12

References

(Earliest) J:16169 Saeki Y, et al., Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993 Dec 27;336(2):317-22
(Latest) J:189831 Frank E, et al., Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice. PLoS One. 2012;7(8):e42395
All references(32)

Other accession IDs

MGD-MRK-16341, MGD-MRK-18738