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Gpr12 Gene Detail
Summary
  • Symbol
    Gpr12
  • Name
    G-protein coupled receptor 12
  • Synonyms
    Gpcr01, Gpcr12, Gpcr20
  • Feature Type
    protein coding gene
  • IDs
    MGI:101909
    NCBI Gene: 14738
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146519208-146522049 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.23 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    28
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101909
 protein coding gene Chr5:146518960-146523274 (-)
129S1/SvImJ ENSMUSGG00200054597
 protein coding gene Chr5:140351826-140352076 (-)
129S1/SvImJ ENSMUSG00200040768
 protein coding gene Chr5:140352010-140352480 (-)
A/J ENSMUSGG00195054960
 protein coding gene Chr5:139959614-139959864 (-)
A/J ENSMUSG00195038895
 protein coding gene Chr5:139959798-139960268 (-)
AKR/J ENSMUSG00220022222
 protein coding gene Chr5:138970157-138970627 (-)
AKR/J ENSMUSGG00220054324
 protein coding gene Chr5:138969973-138970223 (-)
BALB/cJ ENSMUSG00180033171
 protein coding gene Chr5:140342263-140342733 (-)
BALB/cJ ENSMUSGG00180055056
 protein coding gene Chr5:140342079-140342329 (-)
C3H/HeJ ENSMUSGG00175054937
 protein coding gene Chr5:142185215-142185465 (-)
C3H/HeJ ENSMUSG00175011542
 protein coding gene Chr5:142185399-142185869 (-)
C57BL/6NJ ENSMUSGG00215055289
 protein coding gene Chr5:139908809-139909059 (-)
C57BL/6NJ ENSMUSG00215038585
 protein coding gene Chr5:139908993-139909463 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028027
 protein coding gene Chr5:140154360-140157182 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054660
 protein coding gene Chr5:141106114-141106364 (-)
CBA/J ENSMUSG00210023297
 protein coding gene Chr5:141106298-141106768 (-)
DBA/2J ENSMUSG00185037210
 protein coding gene Chr5:144071643-144072113 (-)
DBA/2J ENSMUSGG00185057639
 protein coding gene Chr5:144071459-144071709 (-)
FVB/NJ ENSMUSGG00205054226
 protein coding gene Chr5:139719444-139719694 (-)
FVB/NJ ENSMUSG00205029961
 protein coding gene Chr5:139719628-139720098 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230028753
 protein coding gene Chr5:148068970-148069440 (-)
LP/J ENSMUSGG00230055483
 protein coding gene Chr5:148068786-148069036 (-)
NOD/ShiLtJ ENSMUSG00190039327
 protein coding gene Chr5:139718595-139719065 (-)
NOD/ShiLtJ ENSMUSGG00190054650
 protein coding gene Chr5:139718411-139718661 (-)
NZO/HlLtJ ENSMUSG00225007723
 protein coding gene Chr5:155822075-155822545 (-)
NZO/HlLtJ ENSMUSGG00225055180
 protein coding gene Chr5:155821891-155822141 (-)
PWK/PhJ ENSLUMG00010018427
 protein coding gene Chr5:138798560-138799940 (-)
SPRET/EiJ ENSMSPG00010006106
 protein coding gene Chr5:141602956-141604688 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GPR12, G protein-coupled receptor 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR12, G protein-coupled receptor 12
  • Synonyms
    GPCR12, GPCR21, PPP1R84
  • Links
    NCBI Gene ID: 2835
    UniProt: P47775

  • Chr Location
    13q12.13; chr13:26755200-26760802 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gpr12 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in obesity, increased cholesterol, glucose and triglyceride levels and decreased energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    661
  • Tissues
    34
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041468 Ensembl Gene Model | MGI Sequence Detail 2842 C57BL/6J ±  kb
    transcript ENSMUST00000036211 Ensembl | MGI Sequence Detail 2219 Not Applicable  
    polypeptide ENSMUSP00000038245 Ensembl | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-16341, MGD-MRK-18738
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:16169 Saeki Y, et al., Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993 Dec 27;336(2):317-22
    • Latest
      J:298881 Hsiao K, et al., A Thalamic Orphan Receptor Drives Variability in Short-Term Memory. Cell. 2020 Oct 15;183(2):522-536.e19
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory