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Gpr12
Gene Detail
 Symbol
Name
ID
Gpr12
G-protein coupled receptor 12
MGI:101909
Synonyms Gpcr01, Gpcr12, Gpcr20
Feature Type protein coding gene
Genetic Map
Chromosome 5
85.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:146582151-146585239 bp, - strand
From Ensembl annotation of GRCm38

  3089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GPR6-like G protein-coupled receptor
Gene Tree: Gpr12

Human
homologs
Human Homolog GPR12, G protein-coupled receptor 12
NCBI Gene ID 2835
neXtProt AC  NX_P47775
Human Synonyms  GPCR12, GPCR21
Human Chr (Location)  13q12; chr13:26755200-26760785 (-)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
 
Homozygous mutation of this gene results in obesity, increased cholesterol, glucose and triglyceride levels and decreased energy expenditure.
 
Human Diseases Modeled Using Mouse Gpr12 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular calcium ion homeostasis, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, phosphatidylcholine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (64)    Tissues (34)    Images (13)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 64
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000041468 (Evidence)
Entrez Gene14738 (Evidence)
DFCITC1586303, TC1716227
DoTSDT.40139880, DT.60100428
NIA Mouse Gene IndexU026956
Consensus CDS ProjectCCDS19871.1
International Mouse Knockout Project StatusGpr12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041468 Ensembl Gene Model | MGI Sequence Detail 3089 C57BL/6J ±  kb
transcript ENSMUST00000036211 Ensembl | MGI Sequence Detail 2468 Not Applicable 
polypeptide ENSMUSP00000038245 Ensembl | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000599 G protein-coupled receptor 12
InterPro IPR000723 G protein-coupled receptor 3/6/12 orphan
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001636 G-protein coupled receptor 12
References (Earliest) J:16169 Saeki Y, et al., Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993 Dec 27;336(2):317-22
(Latest) J:189831 Frank E, et al., Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice. PLoS One. 2012;7(8):e42395
All references(32)
Other
accession IDs
MGD-MRK-16341, MGD-MRK-18738

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory