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Gpr3 Gene Detail
Summary
  • Symbol
    Gpr3
  • Name
    G-protein coupled receptor 3
  • Synonyms
    Gpcr21, Gpcr3
  • Feature Type
    protein coding gene
  • IDs
    MGI:101908
    NCBI Gene: 14748
  • Gene Overview
    MyGene.info: GPR3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:133209340-133212536 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3197 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.24 cM, cytoband D3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GPR3, G protein-coupled receptor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GPR3, G protein-coupled receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACCA
  • Links
    NCBI Gene ID: 2827
    neXtProt AC: NX_P46089
    UniProt: P46089

  • Chr Location
    1p36.11; chr1:27392644-27395814 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one allele display an increased thermal nociceptive threshold while females homozygous for another allele display age-related reproductive failure due to ovulation of a progressively increasing proportion of developmentally incompetent oocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010474 VEGA Gene Model | MGI Sequence Detail 3197 C57BL/6J ±  kb
    transcript OTTMUST00000024395 VEGA | MGI Sequence Detail 2518 Not Applicable  
    polypeptide OTTMUSP00000011224 VEGA | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      72 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16342, MGD-MRK-18737
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:16169 Saeki Y, et al., Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993 Dec 27;336(2):317-22
    • Latest
      J:257084 Firmani LD, et al., The switch from cAMP-independent to cAMP-dependent arrest of meiotic prophase is associated with coordinated GPR3 and CDK1 expression in mouse oocytes. Dev Biol. 2018 Feb 1;434(1):196-205

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory