Gpr3
Gene Detail

Symbol Name ID

Gpr3 G-protein coupled receptor 3 MGI:101908

Synonyms

Gpcr21, Gpcr3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

66.24 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:133209340-133212536 bp, - strand From VEGA annotation of GRCm38   3197 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gpr3 ± 2 cM)

Protein SuperFamily: GPR6-like G protein-coupled receptor
Gene Tree: Gpr3

Human ortholog

GPR3 G protein-coupled receptor 3 NCBI Gene ID 2827
Human Synonyms: ACCA
Human Chr1:27719152-27722318 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for one allele display an increased thermal nociceptive threshold while females homozygous for another allele display age-related reproductive failure due to ovulation of a progressively increasing proportion of developmentally incompetent oocytes.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	elevation of cytosolic calcium ion concentration, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (130)    Tissues (70)    Images (36)
Theiler Stages: 28

Assay Type	Results
In situ reporter (knock in)	92
RT-PCR	38

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010474 (Evidence)
Ensembl Gene Model	ENSMUSG00000049649 (Evidence)
Entrez Gene	14748 (Evidence)
UniGene	4721
DFCI	TC1587207, TC1622156
DoTS	DT.110843563, DT.40139881
NIA Mouse Gene Index	U127424
Consensus CDS Project	CCDS18743.1
International Mouse Knockout Project Status	Gpr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010474	VEGA Gene Model | MGI Sequence Detail	3197	C57BL/6J
transcript	OTTMUST00000024395	VEGA | MGI Sequence Detail	2518	Not Applicable
polypeptide	OTTMUSP00000011224	VEGA | MGI Sequence Detail	330	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000984	GPR3 orphan receptor
InterPro	IPR000723	GPR orphan receptor
Protein Ontology	PR:000001643	G-protein coupled receptor 3

References

(Earliest) J:16169 Saeki Y, et al., Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993 Dec 27;336(2):317-22
(Latest) J:181834 Su YQ, et al., MARF1 regulates essential oogenic processes in mice. Science. 2012 Mar 23;335(6075):1496-9
All references(37)

Other accession IDs

MGD-MRK-16342, MGD-MRK-18737