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Pou2f1
Gene Detail
Symbol

Name
ID
Pou2f1
POU domain, class 2, transcription factor 1
MGI:101898
BioType Conflict
Synonyms
2810482H01Rik, oct-1, Oct1, Oct-1A, Oct-1B, Oct-1C, Oct-1z, Otf1, Otf-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
73.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr1:165865154-166002634 bp, - strand
From NCBI annotation of GRCm38

  137481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor Oct-1

Human
homologs
Human Homolog POU2F1, POU class 2 homeobox 1
NCBI Gene ID 5451
neXtProt AC  NX_P14859
Human Synonyms  OCT1, oct-1B, OTF1
Human Chr (Location)  1q24.2; chr1:167220829-167427345 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(88) : Gene trapped(82) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size.
 
Interactions
Pou2f1 interacts with 617 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process lens induction in camera-type eye, negative regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (85)    Tissues (77)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
RT-PCR 12
RNase protection 7
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(5) cDNA(19) Primer pair(4) Other(2)
Microarray probesets(6)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18986 NCBI Gene Model | MGI Sequence Detail 137481 C57BL/6J ±  kb
transcript NM_198934 RefSeq | MGI Sequence Detail 13050 C57BL/6 
polypeptide P25425 UniProt | EBI | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(15) UniProt(9)
Polymorphisms
RFLP(3) : SNPs within 2kb(838 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR000972 Octamer-binding transcription factor
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013035 POU domain, class 2, transcription factor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:9555 Sturm RA, et al., The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 1988 Dec;2(12A):1582-99
(Latest) J:212499 Kim LK, et al., Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Mol Cell. 2014 Apr 10;54(1):56-66
All references(106)
Other
accession IDs
MGD-MRK-12974, MGD-MRK-13060, MGD-MRK-13066, MGD-MRK-18725, MGI:2443655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory