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Pou2f1 Gene Detail
Summary
  • Symbol
    Pou2f1
  • Name
    POU domain, class 2, transcription factor 1
  • Synonyms
    2810482H01Rik, oct-1, Oct1, Oct-1A, Oct-1B, Oct-1C, Oct-1z, Otf1, Otf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101898
    NCBI Gene: 18986
  • Gene Overview
    MyGene.info: POU2F1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:165865154-166002678 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      137525 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 73.21 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OCT1, oct-1B, OTF1
  • Links
    NCBI Gene ID: 5451
    neXtProt AC: NX_P14859
    UniProt: P14859

  • Chr Location
    1q24.2; chr1:167220829-167427345 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034833 VEGA Gene Model | MGI Sequence Detail 137525 C57BL/6J ±  kb
    transcript OTTMUST00000088539 VEGA | MGI Sequence Detail 13022 Not Applicable  
    polypeptide OTTMUSP00000048257 VEGA | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      832 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 5
      cDNA 20
      Primer pair 5
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12974, MGD-MRK-13060, MGD-MRK-13066, MGD-MRK-18725, MGI:2443655
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 15
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:9555 Sturm RA, et al., The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 1988 Dec;2(12A):1582-99
    • Latest
      J:260814 Akhmedov A, et al., Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways. Cardiovasc Res. 2017 Apr 1;113(5):498-507

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory