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Pou2f1 Gene Detail
Summary
  • Symbol
    Pou2f1
  • Name
    POU domain, class 2, transcription factor 1
  • Synonyms
    2810482H01Rik, oct-1, Oct1, Oct-1A, Oct-1B, Oct-1C, Oct-1z, Otf1, Otf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101898
    NCBI Gene: 18986
  • Gene Overview
    MyGene.info: POU2F1
Location & Maps
more
  • Sequence Map
    Chr1:165865154-166002678 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      137525 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OCT1, oct-1B, OTF1
  • Links
    NCBI Gene ID: 5451
    neXtProt AC: NX_P14859

  • Chr Location
    1q24.2; chr1:167220829-167427345 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    90
  • Chemically induced (other)
    2
  • Gene trapped
    82
  • Targeted
    6
  • Genomic Mutations
    2 involving Pou2f1
  • Incidental Mutations
Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034833 VEGA Gene Model | MGI Sequence Detail 137525 C57BL/6J ±  kb
transcript OTTMUST00000088539 VEGA | MGI Sequence Detail 13022 Not Applicable  
polypeptide OTTMUSP00000048257 VEGA | MGI Sequence Detail 793 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    832 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 31
    Genomic 5
    cDNA 19
    Primer pair 5
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12974, MGD-MRK-13060, MGD-MRK-13066, MGD-MRK-18725, MGI:2443655
References
more
  • Summaries
    All 101
    Developmental Gene Expression 14
    Gene Ontology 19
    Phenotypes 18
  • Earliest
    J:9555 Sturm RA, et al., The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 1988 Dec;2(12A):1582-99
  • Latest
    J:226380 Bery A, et al., Characterization of enhancers active in the mouse embryonic cerebral cortex suggests Sox/Pou cis-regulatory logics and heterogeneity of cortical progenitors. Cereb Cortex. 2014 Nov;24(11):2822-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory