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Gene Detail
POU domain, class 2, transcription factor 1
BioType Conflict
Synonyms 2810482H01Rik, oct-1, Oct1, Oct-1A, Oct-1B, Oct-1C, Oct-1z, Otf1, Otf-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
73.21 cM
Detailed Genetic Map ± 1 cM

Mapping data(14)
Sequence Map
Chr1:165865154-166002634 bp, - strand
From NCBI annotation of GRCm38

  137481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:37658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor Oct-1

Human Homolog POU2F1, POU class 2 homeobox 1
NCBI Gene ID 5451
neXtProt AC  NX_P14859
Human Synonyms  OCT1, oct-1B, OTF1
Human Chr (Location)  1q24.2; chr1:167220829-167427345 (+)  GRCh38
alleles, and
All mutations/alleles(88) : Gene trapped(82) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size.
Pou2f1 interacts with 617 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (21 annotations)
Process lens induction in camera-type eye, negative regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Literature Summary: (13 records)
Data Summary: Results (85)    Tissues (77)    Images (11)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 27, 28
Assay TypeResults
RNA in situ 66
RNase protection 7
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(30) Genomic(5) cDNA(19) Primer pair(4) Other(2)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000034833 (Evidence), OTTMUSG00000044454 (Evidence)
Ensembl Gene ModelENSMUSG00000026565 (Evidence), ENSMUSG00000099187 (Evidence)
Entrez Gene18986 (Evidence)
DFCITC1583900, TC1595006, TC1595238, TC1674786, TC1686504, TC1694677
DoTSDT.101378934, DT.101378935, DT.101378936, DT.101378937, DT.101378938, DT.101735270, DT.101735272, DT.102557262, DT.110932466, DT.110932468, DT.87050388, DT.87057258, DT.91338642, DT.91338645, DT.91338646
NIA Mouse Gene IndexU022001
Consensus CDS ProjectCCDS15444.1, CCDS35760.1, CCDS35761.1, CCDS48430.1
International Mouse Knockout Project StatusPou2f1
Representative SequencesLengthStrain/SpeciesFlank
genomic 18986 NCBI Gene Model | MGI Sequence Detail 137481 C57BL/6J ±  kb
transcript NM_198934 RefSeq | MGI Sequence Detail 13050 C57BL/6 
polypeptide P25425 UniProt | EBI | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(15) UniProt(9)
Polymorphisms RFLP(3) : SNPs within 2kb(838 from dbSNP Build 137)
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR000972 Octamer-binding transcription factor
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013035 POU domain, class 2, transcription factor 1
Graphical View of Protein Domain Structure
References (Earliest) J:9555 Sturm RA, et al., The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 1988 Dec;2(12A):1582-99
(Latest) J:212499 Kim LK, et al., Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Mol Cell. 2014 Apr 10;54(1):56-66
All references(106)
accession IDs
MGD-MRK-12974, MGD-MRK-13060, MGD-MRK-13066, MGD-MRK-18725, MGI:2443655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory