About   Help   FAQ
Pou2f1 Gene Detail
Summary
  • Symbol
    Pou2f1
  • Name
    POU domain, class 2, transcription factor 1
  • Synonyms
    2810482H01Rik, oct-1, Oct1, Oct-1A, Oct-1B, Oct-1C, Oct-1z, Otf-1, Otf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101898
    NCBI Gene: 18986
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:165692723-165830247 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 73.21 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2423 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101898
 protein coding gene Chr1:165692719-165830318 (-)
129S1/SvImJ ENSMUSG00200045605
 protein coding gene Chr1:163194445-163331990 (-)
A/J ENSMUSG00195046747
 protein coding gene Chr1:162503059-162640614 (-)
AKR/J ENSMUSG00220013495
 protein coding gene Chr1:162291591-162429142 (-)
BALB/cJ ENSMUSG00180031945
 protein coding gene Chr1:162748415-162885963 (-)
C3H/HeJ ENSMUSG00175040097
 protein coding gene Chr1:162844204-162981748 (-)
C57BL/6NJ ENSMUSG00215039474
 protein coding gene Chr1:162630113-162767655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014811
 protein coding gene Chr1:156268187-156408614 (-)
CAST/EiJ ENSTCUG00005018756
 protein coding gene Chr1:161261023-161398743 (-)
CBA/J ENSMUSG00210020458
 protein coding gene Chr1:162718672-162856189 (-)
DBA/2J ENSMUSG00185011103
 protein coding gene Chr1:166963213-167100793 (-)
FVB/NJ ENSMUSG00205009094
 protein coding gene Chr1:161756230-161900875 (-)
JF1/MsJ ENSUMUG00000004399
 protein coding gene Chr1:166114357-166251931 (-)
LP/J ENSMUSG00230023167
 protein coding gene Chr1:166583472-166721010 (-)
NOD/ShiLtJ ENSMUSG00190025094
 protein coding gene Chr1:162549449-162686942 (-)
NZO/HlLtJ ENSMUSG00225004306
 protein coding gene Chr1:170169330-170306859 (-)
PWK/PhJ ENSLUMG00010038655
 protein coding gene Chr1:161485209-161622031 (-)
SPRET/EiJ ENSMSPG00010048468
 protein coding gene Chr1:164995018-165126522 (-)
WSB/EiJ ENSIUOG00005013683
 protein coding gene Chr1:162030132-162167621 (-)



Homology
more
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
  • Synonyms
    OCT1, oct-1B, Oct1Z, OTF1
  • Links
    NCBI Gene ID: 5451
    UniProt: P14859

  • Chr Location
    1q24.2; chr1:167220876-167427345 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    117
  • cDNA Data
    22
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026565 Ensembl Gene Model | MGI Sequence Detail 137525 C57BL/6J ±  kb
    transcript ENSMUST00000160260 Ensembl | MGI Sequence Detail 13022 Not Applicable  
    polypeptide ENSMUSP00000124738 Ensembl | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 5
      cDNA 22
      Primer pair 7
      Other 4
      Antibodies 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12974, MGD-MRK-13060, MGD-MRK-13066, MGD-MRK-18725, MGI:2443655
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 21
      Gene Ontology 21
      Phenotypes 26
    • Earliest
      J:9555 Sturm RA, et al., The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 1988 Dec;2(12A):1582-99
    • Latest
      J:382758 Segarra LC, et al., Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors. Sci Adv. 2026 Mar 20;12(12):eadz3075
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory