Pou2f1
Gene Detail

Symbol Name ID

Pou2f1 POU domain, class 2, transcription factor 1 MGI:101898

Synonyms

2810482H01Rik, oct-1, Oct1, Oct-1A, Oct-1B, Oct-1C, Oct-1z, Otf1, Otf-1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

73.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr1:165865154-166002678 bp, - strand From VEGA annotation of GRCm38   137525 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37658  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor Oct-1
Gene Tree: Pou2f1

Human homologs

Human Homolog		POU2F1, POU class 2 homeobox 1
NCBI Gene ID		5451
neXtProt AC		NX_P14859
Human Synonyms		OCT1, oct-1B, OTF1
Human Chr (Location)		1q24.2; chr1:167190066-167396582 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(88) : Targeted(6) Gene trapped(82)
 

Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	lens induction in camera-type eye, negative regulation of transcription, DNA-dependent, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (87)    Tissues (76)    Images (10)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	65
RT-PCR	15
RNase protection	7

cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(5) cDNA(35) Primer pair(2) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000034833 (Evidence)
Ensembl Gene Model	ENSMUSG00000026565 (Evidence)
Entrez Gene	18986 (Evidence)
UniGene	245261
DFCI	TC1583900, TC1595006, TC1595238, TC1674786, TC1686504, TC1694677
DoTS	DT.101378934, DT.101378935, DT.101378936, DT.101378937, DT.101378938, DT.101735270, DT.101735272, DT.102557262, DT.110932466, DT.110932468, DT.87050388, DT.87057258, DT.91338642, DT.91338645, DT.91338646
NIA Mouse Gene Index	U022001
Consensus CDS Project	CCDS15444.1, CCDS35760.1, CCDS35761.1, CCDS48430.1
International Mouse Knockout Project Status	Pou2f1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034833	VEGA Gene Model | MGI Sequence Detail	137525	C57BL/6J
transcript	OTTMUST00000088539	VEGA | MGI Sequence Detail	13022	Not Applicable
polypeptide	OTTMUSP00000048257	VEGA | MGI Sequence Detail	793	Not Applicable

All sequences(131) RefSeq(8) UniProt(10)

Polymorphisms

RFLP(3) : SNPs(697 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR010982	Lambda repressor-like, DNA-binding domain
InterPro	IPR000972	Octamer-binding transcription factor
InterPro	IPR013847	POU domain
InterPro	IPR000327	POU-specific
Protein Ontology	PR:000013035	POU domain, class 2, transcription factor 1

References

(Earliest) J:9555 Sturm RA, et al., The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 1988 Dec;2(12A):1582-99
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(105)

Other accession IDs

MGD-MRK-12974, MGD-MRK-13060, MGD-MRK-13066, MGD-MRK-18725, MGI:2443655