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Pou2f2
Gene Detail
Symbol

Name
ID
Pou2f2
POU domain, class 2, transcription factor 2
MGI:101897
BioType Conflict
Synonyms
Oct-2, Oct2a, Oct2b, Otf2, Otf-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:25087344-25159922 bp, - strand
From VEGA annotation of GRCm38

  72579 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor Oct-2

Human
homologs
Human Homolog POU2F2, POU class 2 homeobox 2
NCBI Gene ID 5452
neXtProt AC  NX_P09086
Human Synonyms  Oct-2, OCT2, OTF2
Human Chr (Location)  19q13.2; chr19:42086110-42132473 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(12) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this locus results in failed B cell maturation and death within hours of birth.
 
Interactions
Pou2f2 interacts with 208 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell maturation, immunoglobulin secretion, ...
Component cell, cytoplasm, ...
Function DNA binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (121)    Tissues (109)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
RT-PCR 8
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(4) cDNA(40) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020444 (Evidence)
Ensembl Gene ModelENSMUSG00000008496 (Evidence), ENSMUSG00000099297 (Evidence)
Entrez Gene18987 (Evidence)
UniGene76683
DFCITC1586123, TC1591393, TC1595641, TC1596109, TC1711613
DoTSDT.101171077, DT.101367268, DT.102555189, DT.87050318, DT.87050320, DT.91290955, DT.91444141, DT.91444142
NIA Mouse Gene IndexU028268
Consensus CDS ProjectCCDS39834.1, CCDS52143.1, CCDS52144.1, CCDS52145.1
International Mouse Knockout Project StatusPou2f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020444 VEGA Gene Model | MGI Sequence Detail 72579 C57BL/6J ±  kb
transcript OTTMUST00000048571 VEGA | MGI Sequence Detail 1934 Not Applicable 
polypeptide OTTMUSP00000022300 VEGA | MGI Sequence Detail 583 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(40) UniProt(4)
Polymorphisms
RFLP(3) : SNPs within 2kb(310 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR000972 Octamer-binding transcription factor
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013036 POU domain, class 2, transcription factor 2
References
(Earliest) J:9502 Muller MM, et al., A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature. 1988 Dec 8;336(6199):544-51
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(75)
Other
accession IDs
MGD-MRK-12975, MGD-MRK-13062, MGD-MRK-13069, MGD-MRK-18724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory