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Pou2f2
Gene Detail
 Symbol
Name
ID
Pou2f2
POU domain, class 2, transcription factor 2
MGI:101897
BioType Conflict
Synonyms Oct-2, Oct2a, Oct2b, Otf2, Otf-2
Feature Type protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:25091114-25132460 bp, - strand
From NCBI annotation of GRCm38

  41347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: transcription factor Oct-2

Human
homologs
Human Homolog POU2F2, POU class 2 homeobox 2
NCBI Gene ID 5452
neXtProt AC  NX_P09086
Human Synonyms  Oct-2, OCT2, OTF2
Human Chr (Location)  19q13.2; chr19:42086110-42132473 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(4) Gene trapped(2)
 
Homozygous inactivation of this locus results in failed B cell maturation and death within hours of birth.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell maturation, immunoglobulin secretion, ...
Component cell, cytoplasm, ...
Function DNA binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (128)    Tissues (113)    Images (23)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 113
RT-PCR 15
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(47) Genomic(4) cDNA(40) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020444 (Evidence), OTTMUSG00000044460 (Evidence), OTTMUSG00000044459 (Evidence) (also overlaps Gm27237)
Ensembl Gene ModelENSMUSG00000008496 (Evidence), ENSMUSG00000099297 (Evidence)
Entrez Gene18987 (Evidence)
UniGene76683
DFCITC1586123, TC1591393, TC1595641, TC1596109, TC1711613
DoTSDT.101171077, DT.101367268, DT.102555189, DT.87050318, DT.87050320, DT.91290955, DT.91444141, DT.91444142
NIA Mouse Gene IndexU028268
Consensus CDS ProjectCCDS39834.1, CCDS52143.1, CCDS52144.1, CCDS52145.1
International Mouse Knockout Project StatusPou2f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18987 NCBI Gene Model | MGI Sequence Detail 41347 C57BL/6J ±  kb
transcript NM_001163554 RefSeq | MGI Sequence Detail 3323 Not Specified 
polypeptide Q00196 UniProt | EBI | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(40) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR000972 Octamer-binding transcription factor
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013036 POU domain, class 2, transcription factor 2
Graphical View of Protein Domain Structure
References (Earliest) J:9502 Muller MM, et al., A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature. 1988 Dec 8;336(6199):544-51
(Latest) J:190912 Karnowski A, et al., B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med. 2012 Oct 22;209(11):2049-64
All references(73)
Other
accession IDs
MGD-MRK-12975, MGD-MRK-13062, MGD-MRK-13069, MGD-MRK-18724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory