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Pou2f2 Gene Detail
Summary
  • Symbol
    Pou2f2
  • Name
    POU domain, class 2, transcription factor 2
  • Synonyms
    Oct-2, Oct2a, Oct2b, Oct2c, Oct2d, Otf2, Otf-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101897
    NCBI Gene: 18987
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25091114-25179993 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101897
protein coding gene Chr7:25087344-25179993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031854
protein coding gene Chr7:23514078-23600380 (-)
A/J MGP_AJ_G0031833
protein coding gene Chr7:22926834-23002668 (-)
AKR/J MGP_AKRJ_G0031762
protein coding gene Chr7:23462050-23540290 (-)
BALB/cJ MGP_BALBcJ_G0031840
protein coding gene Chr7:23131616-23211528 (-)
C3H/HeJ MGP_C3HHeJ_G0031559
protein coding gene Chr7:23887026-23969714 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032302
protein coding gene Chr7:24300711-24354813 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029357
protein coding gene Chr7:24355290-24427227 (-)
CAST/EiJ MGP_CASTEiJ_G0030899
protein coding gene Chr7:17361295-17434688 (-)
CBA/J MGP_CBAJ_G0031524
protein coding gene Chr7:25191471-25284222 (-)
DBA/2J MGP_DBA2J_G0031678
protein coding gene Chr7:22831108-22905793 (-)
FVB/NJ MGP_FVBNJ_G0031631
protein coding gene Chr7:22820579-22904908 (-)
LP/J MGP_LPJ_G0031757
protein coding gene Chr7:23825740-23905013 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031668
protein coding gene Chr7:24921431-25007843 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032334
protein coding gene Chr7:23162955-23242080 (-)
PWK/PhJ MGP_PWKPhJ_G0030623
protein coding gene Chr7:17760978-17839396 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030454
protein coding gene Chr7:14476948-14558549 (-)
WSB/EiJ MGP_WSBEiJ_G0031002
protein coding gene Chr7:23332307-23415201 (-)



Homology
more
  • Human Ortholog
    POU2F2, POU class 2 homeobox 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    POU2F2, POU class 2 homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Oct-2, OCT2, OTF2
  • Links
    NCBI Gene ID: 5452
    neXtProt AC: NX_P09086
    UniProt: P09086

  • Chr Location
    19q13.2; chr19:42086110-42197931 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in failed B cell maturation and death within hours of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18987 NCBI Gene Model | MGI Sequence Detail 88880 C57BL/6J ±  kb
    transcript NM_001163554 RefSeq | MGI Sequence Detail 3323 Not Specified  
    polypeptide Q00196 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 4
      cDNA 45
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12975, MGD-MRK-13062, MGD-MRK-13069, MGD-MRK-18724
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 15
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:9502 Muller MM, et al., A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature. 1988 Dec 8;336(6199):544-51
    • Latest
      J:278351 Harris A, et al., Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord. Front Cell Neurosci. 2019;13:184

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/01/2019
    MGI 6.14
    The Jackson Laboratory