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Pou3f1 Gene Detail
Summary
  • Symbol
    Pou3f1
  • Name
    POU domain, class 3, transcription factor 1
  • Synonyms
    Oct6, Oct-6, Otf6, Scip, Test1, Tst1, Tst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101896
    NCBI Gene: 18991
  • Gene Overview
    MyGene.info: POU3F1
Location & Maps
more
  • Sequence Map
    Chr4:124656807-124660655 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3849 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.86 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    POU3F1, POU class 3 homeobox 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    POU3F1, POU class 3 homeobox 1
    Orthology source: HGNC
  • Synonyms
    OCT6, OTF6, SCIP
  • Links
    NCBI Gene ID: 5453
    neXtProt AC: NX_Q03052

  • Chr Location
    1p34.3; chr1:38043851-38046778 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Pou3f1
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit cyanosis and respiratory distress at birth and defective peripheral myelination due to arrested Scwann cell maturation. Mutants usually die at birth or shortly thereafter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042459 VEGA Gene Model | MGI Sequence Detail 3849 C57BL/6J ±  kb
transcript OTTMUST00000111960 VEGA | MGI Sequence Detail 3849 Not Applicable  
polypeptide OTTMUSP00000062821 VEGA | MGI Sequence Detail 449 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    11 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 48
    Genomic 3
    cDNA 29
    Primer pair 9
    Other 7

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13081, MGD-MRK-15042, MGD-MRK-15280, MGD-MRK-18723
References
more
  • Summaries
    All 163
    Developmental Gene Expression 118
    Gene Ontology 11
    Phenotypes 17
  • Earliest
    J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
  • Latest
    J:235958 Rousso DL, et al., Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep. 2016 May 31;15(9):1930-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory