About   Help   FAQ
Pou3f1 Gene Detail
Summary
  • Symbol
    Pou3f1
  • Name
    POU domain, class 3, transcription factor 1
  • Synonyms
    Oct6, Oct-6, Otf6, Scip, Test1, Tst1, Tst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101896
    NCBI Gene: 18991
  • Gene Overview
    MyGene.info: POU3F1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:124656807-124660655 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3849 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.86 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    POU3F1, POU class 3 homeobox 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    POU3F1, POU class 3 homeobox 1
    Orthology source: HGNC
  • Synonyms
    OCT6, OTF6, SCIP
  • Links
    NCBI Gene ID: 5453
    neXtProt AC: NX_Q03052
    UniProt: Q03052

  • Chr Location
    1p34.3; chr1:38043851-38046778 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cyanosis and respiratory distress at birth and defective peripheral myelination due to arrested Scwann cell maturation. Mutants usually die at birth or shortly thereafter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042459 VEGA Gene Model | MGI Sequence Detail 3849 C57BL/6J ±  kb
    transcript OTTMUST00000111960 VEGA | MGI Sequence Detail 3849 Not Applicable  
    polypeptide OTTMUSP00000062821 VEGA | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      11 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 3
      cDNA 29
      Primer pair 10
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13081, MGD-MRK-15042, MGD-MRK-15280, MGD-MRK-18723
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 129
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:254118 De Clercq S, et al., DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation. Cereb Cortex. 2018 Feb 1;28(2):493-509

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory