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Pou3f1
Gene Detail
 Symbol
Name
ID
Pou3f1
POU domain, class 3, transcription factor 1
MGI:101896
Synonyms Oct6, Oct-6, Otf6, Scip, Test1, Tst1, Tst-1
Feature Type protein coding gene
Genetic Map
Chromosome 4
57.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:124656807-124660655 bp, + strand
From VEGA annotation of GRCm38

  3849 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20590  Vertebrate Homology Class
1 mouse; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: POU domain class 3 transcription factor, brain type
Gene Tree: Pou3f1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit cyanosis and respiratory distress at birth and defective peripheral myelination due to arrested Scwann cell maturation. Mutants usually die at birth or shortly thereafter.
 
Interactions
Pou3f1 interacts with 212 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process epidermis development, forebrain development, ...
Component nucleus, transcription factor complex
Function DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (106 records)
Data Summary: Results (406)    Tissues (288)    Images (69)
Theiler Stages: 2, 3, 4, 5, 7, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 47
RNA in situ 324
In situ reporter (knock in) 6
Northern blot 12
RT-PCR 17
cDNA source data(23)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(3) cDNA(27) Primer pair(9) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042459 (Evidence)
Ensembl Gene ModelENSMUSG00000090125 (Evidence)
Entrez Gene18991 (Evidence)
UniGene297371
DFCITC1587975
DoTSDT.55135924
PDB2XSD
Consensus CDS ProjectCCDS57296.1
International Mouse Knockout Project StatusPou3f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042459 VEGA Gene Model | MGI Sequence Detail 3849 C57BL/6J ±  kb
transcript OTTMUST00000111960 VEGA | MGI Sequence Detail 3849 Not Applicable 
polypeptide OTTMUSP00000062821 VEGA | MGI Sequence Detail 449 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
InterPro IPR016362 Transcription factor, homeobox/POU
Protein Ontology PR:000013038 POU domain, class 3, transcription factor 1
References (Earliest) J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
(Latest) J:208651 Louvi A, et al., Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development. 2014 Mar;141(6):1404-15
All references(154)
Other
accession IDs
MGD-MRK-13081, MGD-MRK-15042, MGD-MRK-15280, MGD-MRK-18723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory