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Pou3f1 Gene Detail
Summary
  • Symbol
    Pou3f1
  • Name
    POU domain, class 3, transcription factor 1
  • Synonyms
    Oct6, Oct-6, Otf6, Scip, Test1, Tst1, Tst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101896
    NCBI Gene: 18991
  • Gene Overview
    MyGene.info: POU3F1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124657646-124660655 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.86 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101896
protein coding gene Chr4:124656807-124660655 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028749
protein coding gene Chr4:126195578-126199426 (+)
A/J MGP_AJ_G0028709
protein coding gene Chr4:121243756-121247604 (+)
AKR/J MGP_AKRJ_G0028662
protein coding gene Chr4:124553451-124557299 (+)
BALB/cJ MGP_BALBcJ_G0028731
protein coding gene Chr4:121826295-121830143 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0029173
protein coding gene Chr4:131063354-131067201 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026446
protein coding gene Chr4:114427306-114431155 (+)
CAST/EiJ MGP_CASTEiJ_G0027878
protein coding gene Chr4:122716065-122719909 (+)
CBA/J MGP_CBAJ_G0028411
protein coding gene Chr4:134321714-134325561 (+)
DBA/2J MGP_DBA2J_G0028560
protein coding gene Chr4:121729504-121733420 (+)
FVB/NJ MGP_FVBNJ_G0028527
protein coding gene Chr4:120349131-120352979 (+)
LP/J MGP_LPJ_G0028662
protein coding gene Chr4:126498052-126501900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028553
protein coding gene Chr4:139316282-139320130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029211
protein coding gene Chr4:124930285-124934133 (+)
PWK/PhJ MGP_PWKPhJ_G0027599
protein coding gene Chr4:118140041-118143891 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027425
protein coding gene Chr4:120703978-120707824 (+)
WSB/EiJ MGP_WSBEiJ_G0027958
protein coding gene Chr4:125004907-125008755 (+)



Homology
more
  • Human Ortholog
    POU3F1, POU class 3 homeobox 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    POU3F1, POU class 3 homeobox 1
    Orthology source: HGNC
  • Synonyms
    OCT6, OTF6, SCIP
  • Links
    NCBI Gene ID: 5453
    neXtProt AC: NX_Q03052
    UniProt: Q03052

  • Chr Location
    1p34.3; chr1:38043851-38046778 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cyanosis and respiratory distress at birth and defective peripheral myelination due to arrested Scwann cell maturation. Mutants usually die at birth or shortly thereafter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18991 NCBI Gene Model | MGI Sequence Detail 3010 C57BL/6J ±  kb
    transcript NM_011141 RefSeq | MGI Sequence Detail 3013 C57BL/6  
    polypeptide P21952 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 3
      cDNA 30
      Primer pair 10
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13081, MGD-MRK-15042, MGD-MRK-15280, MGD-MRK-18723
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 135
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:260791 Truch K, et al., Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease. Hum Mol Genet. 2018 Mar 15;27(6):1078-1092

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory