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Gene Detail
POU domain, class 3, transcription factor 4
Synonyms Brn4, BRN-4, Otf9
Feature Type protein coding gene
Genetic Map
Chromosome X
48.20 cM
Detailed Genetic Map ± 1 cM

Mapping data(9)
Sequence Map
ChrX:110814280-110817207 bp, + strand
From VEGA annotation of GRCm38

  2928 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: POU domain class 3 transcription factor, brain type
Gene Tree: Pou3f4

Human Homolog POU3F4, POU class 3 homeobox 4
NCBI Gene ID 5456
neXtProt AC  NX_P49335
Human Synonyms  BRAIN-4, BRN4, BRN-4, DFN3, DFNX2, OCT-9, OTF9, OTF-9
Human Chr (Location)  Xq21.1; chrX:83508261-83509767 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human POU3F4
alleles, and
All mutations/alleles(5) : Radiation induced(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from APF )
Homozygotes for spontaneous, radiation-induced and targeted null mutations exhibit developmental malformations of the inner ear resulting in head-shaking and hearing loss.
Human Diseases Modeled Using Mouse Pou3f4 (1)    Alleles Annotated to Human Diseases(4)   
Pou3f4 interacts with 3 markers (Mir541, Mir758, Mir5101)
Gene Ontology
All GO classifications: (18 annotations)
Process cochlea morphogenesis, forebrain neuron differentiation, ...
Component intracellular, nucleus
Function AT DNA binding, DNA binding, ...
External Resources: FuncBase
Literature Summary: (63 records)
Data Summary: Results (268)    Tissues (189)    Images (27)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 262
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(15) Genomic(2) cDNA(9) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000018379 (Evidence)
Ensembl Gene ModelENSMUSG00000056854 (Evidence)
Entrez Gene18994 (Evidence)
DFCITC1603471, TC1606886, TC1660269
DoTSDT.101336841, DT.99857103
NIA Mouse Gene IndexU020145, U020146
Consensus CDS ProjectCCDS30355.1
International Mouse Knockout Project StatusPou3f4
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018379 VEGA Gene Model | MGI Sequence Detail 2928 C57BL/6J ±  kb
transcript OTTMUST00000044372 VEGA | MGI Sequence Detail 2928 Not Applicable 
polypeptide OTTMUSP00000019934 VEGA | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(3 from dbSNP Build 137)
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
InterPro IPR016362 Transcription factor, homeobox/POU
Protein Ontology PR:000013040 POU domain, class 3, transcription factor 4
References (Earliest) J:13741 Phillips RJS, et al., New sex-linked mutant - Bhd. Mouse News Lett. 1978;58:43-4
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(110)
Disease annotation references (5)
accession IDs
MGD-MRK-13084, MGD-MRK-14438, MGD-MRK-1626, MGD-MRK-18721, MGI:98317

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory