About   Help   FAQ
Pou3f4 Gene Detail
Summary
  • Symbol
    Pou3f4
  • Name
    POU domain, class 3, transcription factor 4
  • Synonyms
    Brn4, BRN-4, Otf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:101894
    NCBI Gene: 18994
  • Gene Overview
    MyGene.info: POU3F4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:110814280-110817207 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 48.20 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101894
protein coding gene ChrX:110814280-110819108 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036024
protein coding gene ChrX:107689956-107692883 (+)
A/J MGP_AJ_G0036004
protein coding gene ChrX:107585332-107588243 (+)
AKR/J MGP_AKRJ_G0035923
protein coding gene ChrX:110892794-110895721 (+)
BALB/cJ MGP_BALBcJ_G0035995
protein coding gene ChrX:106200585-106203511 (+)
C3H/HeJ MGP_C3HHeJ_G0035701
protein coding gene ChrX:108123314-108126244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036520
protein coding gene ChrX:110809852-110812767 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033348
protein coding gene ChrX:104392779-104395725 (+)
CAST/EiJ MGP_CASTEiJ_G0034987
protein coding gene ChrX:92071075-92074002 (+)
CBA/J MGP_CBAJ_G0035677
protein coding gene ChrX:114308288-114311214 (+)
DBA/2J MGP_DBA2J_G0035830
protein coding gene ChrX:106704471-106707394 (+)
FVB/NJ MGP_FVBNJ_G0035771
protein coding gene ChrX:106068959-106071885 (+)
LP/J MGP_LPJ_G0035923
protein coding gene ChrX:108592595-108595522 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035802
protein coding gene ChrX:119526639-119529554 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036547
protein coding gene ChrX:107222799-107225729 (+)
PWK/PhJ MGP_PWKPhJ_G0034683
protein coding gene ChrX:89602783-89605723 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034512
protein coding gene ChrX:92946911-92949839 (+)
WSB/EiJ MGP_WSBEiJ_G0035125
protein coding gene ChrX:105927217-105930140 (+)



Homology
more
  • Human Ortholog
    POU3F4, POU class 3 homeobox 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    POU3F4, POU class 3 homeobox 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRAIN-4, BRN4, BRN-4, DFN3, DFNX2, OCT-9, OTF9, OTF-9
  • Links
    NCBI Gene ID: 5456
    neXtProt AC: NX_P49335
    UniProt: P49335

  • Chr Location
    Xq21.1; chrX:83508261-83509767 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous, radiation-induced and targeted null mutations exhibit developmental malformations of the inner ear resulting in head-shaking and hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056854 Ensembl Gene Model | MGI Sequence Detail 2928 C57BL/6J ±  kb
    transcript ENSMUST00000078229 Ensembl | MGI Sequence Detail 2928 Not Applicable  
    polypeptide ENSMUSP00000077354 Ensembl | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 14
      Primer pair 2
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13084, MGD-MRK-14438, MGD-MRK-1626, MGD-MRK-18721, MGI:98317
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 76
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:487 Hara Y, et al., Structure and evolution of four POU domain genes expressed in mouse brain. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3280-4
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory