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Tead1
Gene Detail
Symbol

Name
ID
Tead1
TEA domain family member 1
MGI:101876
Synonyms
2610024B07Rik, B230114H05Rik, Gtrgeo5, mTEF-1, Tcf13, TEAD-1, TEF-1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
58.80 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:112679318-112906807 bp, + strand
From VEGA annotation of GRCm38

  227490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcriptional enhancer factor
Gene Tree: Tead1

Human
homologs
Human Homolog TEAD1, TEA domain family member 1 (SV40 transcriptional enhancer factor)
NCBI Gene ID 7003
neXtProt AC  NX_P28347
Human Synonyms  AA, NTEF-1, REF1, TCF13, TCF-13, TEAD-1, TEF-1
Human Chr (Location)  11p15.2; chr11:12674422-12944737 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TEAD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(567) : Gene trapped(563) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die between embryonic day 11 and 12.5. Abnormalities were seen in heart development.
 
Interactions
Tead1 interacts with 556 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cellular response to retinoic acid, embryonic heart tube morphogenesis, ...
Component cytoplasm, Golgi apparatus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (202)    Tissues (182)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 161
Northern blot 10
RT-PCR 28
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(27) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036056 (Evidence)
Ensembl Gene ModelENSMUSG00000055320 (Evidence)
Entrez Gene21676 (Evidence)
DFCITC1630385, TC1598824, TC1598542, TC1584118, TC1583164
DoTSDT.488856, DT.40149941, DT.94154201, DT.489389, DT.94154214
NIA Mouse Gene IndexU008646, U008647
Consensus CDS ProjectCCDS52365.1, CCDS52366.1, CCDS52367.1
International Mouse Knockout Project StatusTead1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036056 VEGA Gene Model | MGI Sequence Detail 227490 C57BL/6J ±  kb
transcript OTTMUST00000092575 VEGA | MGI Sequence Detail 9964 Not Applicable 
polypeptide OTTMUSP00000051199 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(17) UniProt(23)
Polymorphisms
SNPs within 2kb(2185 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000818 TEA/ATTS
InterPro IPR016361 Transcriptional enhancer factor
Protein Ontology PR:000016218 transcriptional enhancer factor TEF-1
References
(Earliest) J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
(Latest) J:213875 Yu FX, et al., Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16;25(6):822-30
All references(78)
Other
accession IDs
MGD-MRK-18702, MGD-MRK-18736, MGI:1917551, MGI:2444852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory