Tead1
Gene Detail

Symbol Name ID

Tead1 TEA domain family member 1 MGI:101876

BioType Conflict

Synonyms

2610024B07Rik, B230114H05Rik, Gtrgeo5, mTEF-1, Tcf13, TEAD-1, TEF-1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

58.80 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:112679320-112906805 bp, + strand From NCBI annotation of GRCm38   227486 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcriptional enhancer factor

Human homologs

Human Homolog		TEAD1, TEA domain family member 1 (SV40 transcriptional enhancer factor)
NCBI Gene ID		7003
neXtProt AC		NX_P28347
Human Synonyms		AA, NTEF-1, REF1, TCF13, TCF-13, TEAD-1, TEF-1
Human Chr (Location)		11p15.2; chr11:12695969-12966284 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TEAD1

Alleles and phenotypes

All alleles(565) : Targeted(2) Gene trapped(563)
 

Mice homozygous for disruptions in this gene die between embryonic day 11 and 12.5. Abnormalities were seen in heart development.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	embryonic heart tube morphogenesis, heart development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (219)    Tissues (186)    Images (17)
Theiler Stages: 1, 2, 3, 4, 5, 10, 14, 15, 16, 17, 19, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	161
Northern blot	10
RT-PCR	45

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(27) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000036056 (Evidence), OTTMUSG00000022886 (Evidence)
Ensembl Gene Model	ENSMUSG00000055320 (Evidence), ENSMUSG00000055593 (Evidence)
Entrez Gene	21676 (Evidence)
DFCI	TC1583164, TC1584118, TC1598542, TC1598824, TC1630385
DoTS	DT.40149941, DT.488856, DT.489389, DT.94154201, DT.94154214
NIA Mouse Gene Index	U008646, U008647
Consensus CDS Project	CCDS52365.1, CCDS52366.1, CCDS52367.1
International Mouse Knockout Project Status	Tead1

Sequences

Length	Strain/Species
genomic	21676	NCBI Gene Model | MGI Sequence Detail	227486	C57BL/6J
transcript	NM_001166584	RefSeq | MGI Sequence Detail	9962	C57BL/6
polypeptide	P30051	UniProt | EBI | MGI Sequence Detail	426	Not Applicable

All sequences(104) RefSeq(7) UniProt(12)

Polymorphisms

SNPs(1124 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000818	TEA/ATTS
InterPro	IPR016361	Transcriptional enhancer factor
Protein Ontology	PR:000016218	transcriptional enhancer factor TEF-1

Graphical View of Protein Domain Structure

References

(Earliest) J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
(Latest) J:184824 Liu-Chittenden Y, et al., Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012 Jun 15;26(12):1300-5
All references(70)

Other accession IDs

MGD-MRK-18702, MGD-MRK-18736, MGI:1917551, MGI:2444852