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Tead1 Gene Detail
Summary
  • Symbol
    Tead1
  • Name
    TEA domain family member 1
  • Synonyms
    2610024B07Rik, B230114H05Rik, Gtrgeo5, mTEF-1, Tcf13, TEAD-1, TEF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101876
    NCBI Gene: 21676
  • Gene Overview
    MyGene.info: TEAD1
Location & Maps
more
  • Sequence Map
    Chr7:112679318-112906807 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      227490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 58.80 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TEAD1, TEA domain transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TEAD1, TEA domain transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AA, NTEF-1, REF1, TCF13, TCF-13, TEAD-1, TEF-1
  • Links
    NCBI Gene ID: 7003
    neXtProt AC: NX_P28347

  • Chr Location
    11p15.2; chr11:12674422-12944737 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TEAD1 associations

Human Disease Mouse Models
       Sveinsson Chorioretinal Atrophy; SCRA   OMIM: 108985
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 5 alleles in 5 genetic backgrounds
    26 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    568
  • Gene trapped
    563
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Tead1
  • Incidental Mutations
Mice homozygous for disruptions in this gene die between embryonic day 11 and 12.5. Abnormalities were seen in heart development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036056 VEGA Gene Model | MGI Sequence Detail 227490 C57BL/6J ±  kb
transcript OTTMUST00000092575 VEGA | MGI Sequence Detail 9964 Not Applicable  
polypeptide OTTMUSP00000051199 VEGA | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2172 from dbSNP Build 142
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000016218 transcriptional enhancer factor TEF-1
  • InterPro Domains
    IPR000818 TEA/ATTS domain
    IPR016361 Transcriptional enhancer factor, metazoa
Molecular
Reagents
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  • All nucleic 32
    cDNA 28
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-18702, MGD-MRK-18736, MGI:1917551, MGI:2444852
References
more
  • Summaries
    All 76
    Developmental Gene Expression 23
    Gene Ontology 15
    Phenotypes 23
  • Earliest
    J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
  • Latest
    J:223227 Mamada H, et al., Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc. J Cell Sci. 2015 Feb 15;128(4):790-803

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory