About   Help   FAQ
Aldoc Gene Detail
Summary
  • Symbol
    Aldoc
  • Name
    aldolase C, fructose-bisphosphate
  • Synonyms
    Aldo3, Aldolase C, Scrg2, zebrin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:101863
    NCBI Gene: 11676
  • Gene Overview
    MyGene.info: ALDOC
Location & Maps
more
  • Sequence Map
    Chr11:78322968-78327781 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4814 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ALDOC, aldolase, fructose-bisphosphate C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALDOC, aldolase, fructose-bisphosphate C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDC
  • Links
    NCBI Gene ID: 230
    neXtProt AC: NX_P09972

  • Chr Location
    17cen-q12; chr17:28573115-28576948 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Aldoc
Mice homozygous for a knock-in allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000108 VEGA Gene Model | MGI Sequence Detail 4814 C57BL/6J ±  kb
transcript OTTMUST00000000365 VEGA | MGI Sequence Detail 2786 Not Applicable  
polypeptide OTTMUSP00000000160 VEGA | MGI Sequence Detail 363 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003936 fructose-bisphosphate aldolase C
  • EC
  • InterPro Domains
    IPR013785 Aldolase-type TIM barrel
    IPR000741 Fructose-bisphosphate aldolase, class-I
    IPR029768 Fructose-bisphosphate aldolase class-I active site
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 14
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18688, MGI:1328309, MGI:2144291, MGI:2144424
References
more
  • Summaries
    All 66
    Developmental Gene Expression 25
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:21434 Paolella G, et al., Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A. Eur J Biochem. 1986 Apr 15;156(2):229-35
  • Latest
    J:232100 Huang Z, et al., Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. J Neurosci. 2016 May 25;36(21):5833-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory