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Usp45 Gene Detail
Summary
  • Symbol
    Usp45
  • Name
    ubiquitin specific petidase 45
  • Synonyms
    3110003C05Rik, 4930550B20Rik, Gcap7
  • Feature Type
    protein coding gene
  • IDs
    MGI:101850
    NCBI Gene: 77593
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:21767161-21837872 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 8.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101850
protein coding gene Chr4:21767156-21837872 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028092
protein coding gene Chr4:18786546-18859881 (+)
A/J MGP_AJ_G0028050
protein coding gene Chr4:18224221-18300555 (+)
AKR/J MGP_AKRJ_G0028015
protein coding gene Chr4:18644412-18721291 (+)
BALB/cJ MGP_BALBcJ_G0028061
protein coding gene Chr4:18284114-18356545 (+)
C3H/HeJ MGP_C3HHeJ_G0027791
protein coding gene Chr4:18813804-18889712 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028504
protein coding gene Chr4:19548244-19624457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025846
protein coding gene Chr4:16884385-16964641 (+)
CAST/EiJ MGP_CASTEiJ_G0027246
protein coding gene Chr4:18576929-18660353 (+)
CBA/J MGP_CBAJ_G0027764
protein coding gene Chr4:20112192-20190779 (+)
DBA/2J MGP_DBA2J_G0027907
protein coding gene Chr4:18094758-18172574 (+)
FVB/NJ MGP_FVBNJ_G0027873
protein coding gene Chr4:17807336-17878616 (+)
LP/J MGP_LPJ_G0028016
protein coding gene Chr4:18858840-18935910 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027906
protein coding gene Chr4:21341453-21418413 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028563
protein coding gene Chr4:18591193-18678868 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026795
protein coding gene Chr4:18420198-18488739 (+)
WSB/EiJ MGP_WSBEiJ_G0027323
protein coding gene Chr4:18595988-18668751 (+)



Homology
more
  • Human Ortholog
    USP45, ubiquitin specific peptidase 45
  • Vertebrate Orthologs
    8
  • Human Ortholog
    USP45, ubiquitin specific peptidase 45
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 85015
    neXtProt AC: NX_Q70EL2
    UniProt: Q70EL2

  • Chr Location
    6q16.2; chr6:99432306-99515770 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 77593 NCBI Gene Model | MGI Sequence Detail 70712 C57BL/6J ±  kb
transcript NM_152825 RefSeq | MGI Sequence Detail 6018 C57BL/6  
polypeptide Q8K387 UniProt | EBI | MGI Sequence Detail 813 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 55

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18673, MGI:1920359, MGI:1924843, MGI:2140372
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
  • Latest
    J:218236 Perez-Oliva AB, et al., USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. EMBO J. 2015 Feb 3;34(3):326-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory