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Rack1 Gene Detail
Summary
  • Symbol
    Rack1
  • Name
    receptor for activated C kinase 1
  • Synonyms
    GB-like, Gnb2l1, Gnb2-rs1, p205
  • Feature Type
    protein coding gene
  • IDs
    MGI:101849
    NCBI Gene: 14694
Location & Maps
more
  • Sequence Map
    Chr11:48800332-48806434 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6103 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RACK1, receptor for activated C kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RACK1, receptor for activated C kinase 1
    Orthology source: HomoloGene
  • Synonyms
    GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21
  • Links
    NCBI Gene ID: 10399
    neXtProt AC: NX_P63244

  • Chr Location
    5q35.3; chr5:181236928-181243906 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4446
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RACK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    82
  • Chemically induced (other)
    1
  • Gene trapped
    78
  • Targeted
    3
  • Genomic Mutations
    1 involving Rack1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005526 VEGA Gene Model | MGI Sequence Detail 6103 C57BL/6J ±  kb
transcript OTTMUST00000012289 VEGA | MGI Sequence Detail 1447 Not Applicable  
polypeptide OTTMUSP00000043241 VEGA | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 137
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008098 guanine nucleotide-binding protein subunit beta-2-like 1
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 1477
    cDNA 1474
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18672
References
more
  • Summaries
    All 66
    Developmental Gene Expression 10
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:21457 Guillemot F, et al., Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4594-8
  • Latest
    J:211328 Ma J, et al., DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem J. 2014 Jun 20;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory