Gnb2l1
Gene Detail

Symbol Name ID

Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 MGI:101849

Synonyms

GB-like, Gnb2-rs1, p205, Rack1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

28.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:48800332-48806434 bp, + strand From VEGA annotation of GRCm38   6103 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4446  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Gnb2l1

Human homologs

Human Homolog		GNB2L1, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
NCBI Gene ID		10399
neXtProt AC		NX_P63244
Human Synonyms		Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1
Human Chr (Location)		5q35.3; chr5:180663928-180670906 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(79) : Targeted(1) Gene trapped(78)

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	cell projection, cytoplasm, ...
Function	cysteine-type endopeptidase activator activity involved in apoptotic process, ion channel inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (34)    Tissues (25)    Images (5)
Theiler Stages: 21, 23, 25, 28

Assay Type	Results
RNA in situ	34

cDNA source data(1464)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(1470) cDNA(1467) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005526 (Evidence)
Ensembl Gene Model	ENSMUSG00000020372 (Evidence)
Entrez Gene	14694 (Evidence)
UniGene	5305
DFCI	TC1573653, TC1668305, TC1754707
NIA Mouse Gene Index	U012515
Consensus CDS Project	CCDS24585.1
International Mouse Knockout Project Status	Gnb2l1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005526	VEGA Gene Model | MGI Sequence Detail	6103	C57BL/6J
transcript	OTTMUST00000012289	VEGA | MGI Sequence Detail	1447	Not Applicable
polypeptide	OTTMUSP00000043241	VEGA | MGI Sequence Detail	317	Not Applicable

All sequences(54) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020472	G-protein beta WD-40 repeat
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000008098	guanine nucleotide-binding protein subunit beta-2-like 1

References

(Earliest) J:21457 Guillemot F, et al., Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4594-8
(Latest) J:179967 Zheng Y, et al., Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1. FEBS Lett. 2012 Jan 20;586(2):122-6
All references(65)

Other accession IDs

MGD-MRK-18672