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Gnb5 Gene Detail
Summary
  • Symbol
    Gnb5
  • Name
    guanine nucleotide binding protein (G protein), beta 5
  • Synonyms
    Gbeta5, G beta 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:101848
    NCBI Gene: 14697
  • Gene Overview
    MyGene.info: GNB5
Location & Maps
more
  • Sequence Map
    Chr9:75311395-75344964 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33570 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.30 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GNB5, G protein subunit beta 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GNB5, G protein subunit beta 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GB5, IDDCA, LADCI
  • Links
    NCBI Gene ID: 10681
    neXtProt AC: NX_O14775

  • Chr Location
    15q21.2; chr15:52120926-52191368 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human GNB5 associations

Human Disease Mouse Models
       Intellectual Developmental Disorder with Cardiac Arrhythmia; IDDCA   OMIM: 617173
Language Delay and Attention Deficit-Hyperactivity Disorder/Cognitive Impairment with or without Cardiac Arrhythmia; LADCI   OMIM: 617182
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Gnb5
  • Incidental Mutations
Homozygotes for a targeted null mutation are runty and exhibit high preweaning mortality. Survivors are apparently normal, but show prolonged photoresponses and defective adaptation in rod cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032192 Ensembl Gene Model | MGI Sequence Detail 33570 C57BL/6J ±  kb
transcript ENSMUST00000076889 Ensembl | MGI Sequence Detail 1188 Not Applicable  
polypeptide ENSMUSP00000076155 Ensembl | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    418 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 14
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18671
References
more
  • Summaries
    All 52
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:19966 Watson AJ, et al., A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C. J Biol Chem. 1994 Sep 2;269(35):22150-6
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory