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Gnb5 Gene Detail
Summary
  • Symbol
    Gnb5
  • Name
    guanine nucleotide binding protein (G protein), beta 5
  • Synonyms
    Gbeta5, G beta 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:101848
    NCBI Gene: 14697
  • Gene Overview
    MyGene.info: GNB5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:75306288-75345876 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39589 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.30 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GNB5, G protein subunit beta 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GNB5, G protein subunit beta 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GB5, IDDCA, LADCI
  • Links
    NCBI Gene ID: 10681
    neXtProt AC: NX_O14775
    UniProt: O14775

  • Chr Location
    15q21.2; chr15:52120926-52191368 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are runty and exhibit high preweaning mortality. Survivors are apparently normal, but show prolonged photoresponses and defective adaptation in rod cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032192 Ensembl Gene Model | MGI Sequence Detail 39589 C57BL/6J ±  kb
    transcript ENSMUST00000213990 Ensembl | MGI Sequence Detail 1803 Not Applicable  
    polypeptide ENSMUSP00000149938 Ensembl | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      422 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 14
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18671
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:19966 Watson AJ, et al., A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C. J Biol Chem. 1994 Sep 2;269(35):22150-6
    • Latest
      J:253323 Wang Q, et al., Regulator of G-protein signaling Gbeta5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion. FASEB J. 2017 Nov;31(11):4734-4744

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory