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Gnb5
Gene Detail
 Symbol
Name
ID
Gnb5
guanine nucleotide binding protein (G protein), beta 5
MGI:101848
Synonyms Gbeta5, G beta 5
Feature Type protein coding gene
Genetic Map
Chromosome 9
42.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:75311395-75344964 bp, + strand
From Ensembl annotation of GRCm38

  33570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: guanine nucleotide-binding protein, beta subunit
Gene Tree: Gnb5

Human
homologs
Human Homolog GNB5, guanine nucleotide binding protein (G protein), beta 5
NCBI Gene ID 10681
neXtProt AC  NX_O14775
Human Synonyms  GB5
Human Chr (Location)  15q21.2; chr15:52120926-52191368 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(2) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are runty and exhibit high preweaning mortality. Survivors are apparently normal, but show prolonged photoresponses and defective adaptation in rod cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of voltage-gated calcium channel activity, ...
Component cell body, cytosol, ...
Function chaperone binding, G-protein gamma-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (41)    Tissues (30)    Images (4)
Theiler Stages: 1, 2, 3, 4, 23, 28
Assay TypeResults
RNA in situ 24
RT-PCR 17
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(14) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032192 (Evidence)
Entrez Gene14697 (Evidence)
DFCITC1575215, TC1604031, TC1622359
DoTSDT.101210964, DT.489632, DT.99863864
NIA Mouse Gene IndexU043006
PDB2PBI
Consensus CDS ProjectCCDS40692.1
International Mouse Knockout Project StatusGnb5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032192 Ensembl Gene Model | MGI Sequence Detail 33570 C57BL/6J ±  kb
transcript ENSMUST00000076889 Ensembl | MGI Sequence Detail 1188 Not Applicable 
polypeptide ENSMUSP00000076155 Ensembl | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(5) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(401 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001632 G-protein, beta subunit
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR016346 Guanine nucleotide-binding protein, beta subunit
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008101 guanine nucleotide-binding protein subunit beta-5
References (Earliest) J:19966 Watson AJ, et al., A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C. J Biol Chem. 1994 Sep 2;269(35):22150-6
(Latest) J:200166 Tian M, et al., Light-induced translocation of RGS9-1 and Gbeta5L in mouse rod photoreceptors. PLoS One. 2013;8(3):e58832
All references(53)
Other
accession IDs
MGD-MRK-18671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory