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Pla2g1b
Gene Detail
Symbol

Name
ID
Pla2g1b
phospholipase A2, group IB, pancreas
MGI:101842
Synonyms
Pla2a, sPLA2IB
Feature Type
protein coding gene
Genetic Map
Chromosome 5
56.10 cM, cytoband F1-G1.1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:115466262-115474722 bp, + strand
From VEGA annotation of GRCm38

  8461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLA2G1B
Protein SuperFamily: phospholipase A2
Gene Tree: Pla2g1b

Human
homologs
PLA2G1B, phospholipase A2, group IB (pancreas)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5319
neXtProt AC: NX_P04054

Human Synonyms: PLA2, PLA2A, PPLA2

Human Chr (Location): 12q24.31; chr12:120322111-120327789 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
 
Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance.
 
Interactions
Pla2g1b interacts with 23 markers (Mir137, Mir325, Mir465, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (102)    Tissues (102)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 8
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pla2g1b ; ZFIN pla2g1b    NEW 
Molecular
reagents
All nucleic(51) Genomic(1) cDNA(48) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000014666 (Evidence)
Ensembl Gene Model ENSMUSG00000029522 (Evidence)
Entrez Gene 18778 (Evidence)
UniGene 20190
DFCI TC1667504, TC1572376, TC1690888, TC1723504
DoTS DT.101384493, DT.91371003, DT.94240401, DT.94240421, DT.50315103, DT.50315993
NIA Mouse Gene Index U006050
EC 3.1.1.4
Consensus CDS Project CCDS19592.1
International Mouse Phenotyping Consortium Status Pla2g1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014666 VEGA Gene Model | MGI Sequence Detail 8461 C57BL/6J ±  kb
transcript OTTMUST00000034801 VEGA | MGI Sequence Detail 557 Not Applicable 
polypeptide OTTMUSP00000015569 VEGA | MGI Sequence Detail 146 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001211 Phospholipase A2
InterPro IPR013090 Phospholipase A2, active site
InterPro IPR016090 Phospholipase A2 domain
Protein Ontology PR:000012798 phospholipase A2
References
(Earliest) J:19467 Mukherjee AB, et al., Phospholipase A2 enzymes: regulation and physiological role. Biochem Pharmacol. 1994 Jul 5;48(1):1-10
(Latest) J:206547 Qu BX, et al., cPLA2alpha knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons. Brain Res. 2013 Feb 25;1497:101-5
All references(51)
Other
accession IDs
MGD-MRK-13343, MGD-MRK-18663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory