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Pla2g1b
Gene Detail
 Symbol
Name
ID
Pla2g1b
phospholipase A2, group IB, pancreas
MGI:101842
Synonyms Pla2a, sPLA2IB
Feature Type protein coding gene
Genetic Map
Chromosome 5
56.10 cM, cytoband F1-G1.1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:115466262-115474722 bp, + strand
From VEGA annotation of GRCm38

  8461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: phospholipase A2
Gene Tree: Pla2g1b

Human
homologs
Human Homolog PLA2G1B, phospholipase A2, group IB (pancreas)
NCBI Gene ID 5319
neXtProt AC  NX_P04054
Human Synonyms  PLA2, PLA2A, PPLA2
Human Chr (Location)  12q24.31; chr12:120322111-120327789 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
 
Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance.
 
Interactions
Pla2g1b interacts with 23 markers (Mir137, Mir325, Mir465, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process antibacterial humoral response, defense response to Gram-positive bacterium, ...
Component cell surface, extracellular region, ...
Function calcium-dependent phospholipase A2 activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (102)    Tissues (102)    Images (1)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
Northern blot 8
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(1) cDNA(48) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000014666 (Evidence)
Ensembl Gene ModelENSMUSG00000029522 (Evidence)
Entrez Gene18778 (Evidence)
UniGene20190
DFCITC1572376, TC1667504, TC1690888, TC1723504
DoTSDT.101384493, DT.50315103, DT.50315993, DT.91371003, DT.94240401, DT.94240421
NIA Mouse Gene IndexU006050
EC3.1.1.4
Consensus CDS ProjectCCDS19592.1
International Mouse Knockout Project StatusPla2g1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014666 VEGA Gene Model | MGI Sequence Detail 8461 C57BL/6J ±  kb
transcript OTTMUST00000034801 VEGA | MGI Sequence Detail 557 Not Applicable 
polypeptide OTTMUSP00000015569 VEGA | MGI Sequence Detail 146 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001211 Phospholipase A2
InterPro IPR013090 Phospholipase A2, active site
InterPro IPR016090 Phospholipase A2 domain
Protein Ontology PR:000012798 phospholipase A2
References (Earliest) J:19467 Mukherjee AB, et al., Phospholipase A2 enzymes: regulation and physiological role. Biochem Pharmacol. 1994 Jul 5;48(1):1-10
(Latest) J:179161 Thakker P, et al., Cytosolic phospholipase A2alpha blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs. J Immunol. 2011 Aug 15;187(4):1986-97
All references(51)
Other
accession IDs
MGD-MRK-13343, MGD-MRK-18663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory