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Pla2g1b Gene Detail
Summary
  • Symbol
    Pla2g1b
  • Name
    phospholipase A2, group IB, pancreas
  • Synonyms
    Pla2a, sPLA2IB
  • Feature Type
    protein coding gene
  • IDs
    MGI:101842
    NCBI Gene: 18778
  • Gene Overview
    MyGene.info: PLA2G1B
Location & Maps
more
  • Sequence Map
    Chr5:115466262-115474722 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8461 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 56.10 cM, cytoband F1-G1.1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PLA2G1B, phospholipase A2 group IB
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLA2G1B, phospholipase A2 group IB
    Orthology source: HomoloGene
  • Synonyms
    PLA2, PLA2A, PPLA2
  • Links
    NCBI Gene ID: 5319
    neXtProt AC: NX_P04054

  • Chr Location
    12q24.31; chr12:120322111-120327789 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Pla2g1b
Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014666 VEGA Gene Model | MGI Sequence Detail 8461 C57BL/6J ±  kb
transcript OTTMUST00000034801 VEGA | MGI Sequence Detail 557 Not Applicable  
polypeptide OTTMUSP00000015569 VEGA | MGI Sequence Detail 146 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 51
    Genomic 1
    cDNA 48
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-13343, MGD-MRK-18663
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:19467 Mukherjee AB, et al., Phospholipase A2 enzymes: regulation and physiological role. Biochem Pharmacol. 1994 Jul 5;48(1):1-10
  • Latest
    J:206547 Qu BX, et al., cPLA2alpha knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons. Brain Res. 2013 Feb 25;1497:101-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory